CORTICOID -17,21-DICARBOXYLIC ESTERS AND CORTICOSTEROID 17-CABOXYLIC ESTERS 21-CARBONIC ESTERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS
Corticoid 17,21-dicarboxylic esters and corticosteroid 17-carboxylic ester 21-carbonic esters, processes for their preparation and pharmaceuticals containing these compounds Corticoid 17,21-dicarboxylic esters and corticoid 17- carboxylic ester 21-carbonic esters of the formula I are described, in w...
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| creator | BOHN, MANFRED STACHE, ULRICH ALPERMANN, HANS-GEORG DURCKHEIMER, WALTER |
| description | Corticoid 17,21-dicarboxylic esters and corticosteroid 17-carboxylic ester 21-carbonic esters, processes for their preparation and pharmaceuticals containing these compounds Corticoid 17,21-dicarboxylic esters and corticoid 17- carboxylic ester 21-carbonic esters of the formula I are described, in which A is CHOH and CHCl, CH2, C=O or 9(11) double bond; Y is H, F or Cl; Z is H, F or methyl; R(1) is aryl or hetaryl; R(2) is alkyl and R(3) is H or methyl. They are obtained, inter alia, by reacting a compound of the formula II, in which R(S) is OH, with an activated carboxylic acid of the formula III, R(6)-CO-(O)n(C1-C4)-alkyl]m-R(1) III. They have a very strong local and topical antiinflamma-tory action and exhibit a very good ratio of local to systemic antiinflammatory effects. They are used, inter alia, as agents for treating inflammatory dermatoses. |
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They are obtained, inter alia, by reacting a compound of the formula II, in which R(S) is OH, with an activated carboxylic acid of the formula III, R(6)-CO-(O)n(C1-C4)-alkyl]m-R(1) III. They have a very strong local and topical antiinflamma-tory action and exhibit a very good ratio of local to systemic antiinflammatory effects. 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They are obtained, inter alia, by reacting a compound of the formula II, in which R(S) is OH, with an activated carboxylic acid of the formula III, R(6)-CO-(O)n(C1-C4)-alkyl]m-R(1) III. They have a very strong local and topical antiinflamma-tory action and exhibit a very good ratio of local to systemic antiinflammatory effects. They are used, inter alia, as agents for treating inflammatory dermatoses.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjUEKwjAQRbtxIeoZzAEasC3Y9Tid2kCbhCQFXZUicSVaqOfyjKZFXLhxNfB4b_4yeqEyTqASBeNJHqcJLwSCOajTuRbIyDoyloEs2EecwGQnOUf40UI9t_KLYqaNQrKWLCuVYa4iYQIjDQacUHJ-rSswDSC1YQBqG6akAyGFPE6BpQAarVpZ2HW0uPa30W8-dxVtS3JYcT88Oj8O_cXf_bNDSJMs2-9yzP4bb9FoR4o</recordid><startdate>20070703</startdate><enddate>20070703</enddate><creator>BOHN, MANFRED</creator><creator>STACHE, ULRICH</creator><creator>ALPERMANN, HANS-GEORG</creator><creator>DURCKHEIMER, WALTER</creator><scope>EVB</scope></search><sort><creationdate>20070703</creationdate><title>CORTICOID -17,21-DICARBOXYLIC ESTERS AND CORTICOSTEROID 17-CABOXYLIC ESTERS 21-CARBONIC ESTERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS</title><author>BOHN, MANFRED ; STACHE, ULRICH ; ALPERMANN, HANS-GEORG ; DURCKHEIMER, WALTER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2133607C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>BOHN, MANFRED</creatorcontrib><creatorcontrib>STACHE, ULRICH</creatorcontrib><creatorcontrib>ALPERMANN, HANS-GEORG</creatorcontrib><creatorcontrib>DURCKHEIMER, WALTER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BOHN, MANFRED</au><au>STACHE, ULRICH</au><au>ALPERMANN, HANS-GEORG</au><au>DURCKHEIMER, WALTER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CORTICOID -17,21-DICARBOXYLIC ESTERS AND CORTICOSTEROID 17-CABOXYLIC ESTERS 21-CARBONIC ESTERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS</title><date>2007-07-03</date><risdate>2007</risdate><abstract>Corticoid 17,21-dicarboxylic esters and corticosteroid 17-carboxylic ester 21-carbonic esters, processes for their preparation and pharmaceuticals containing these compounds Corticoid 17,21-dicarboxylic esters and corticoid 17- carboxylic ester 21-carbonic esters of the formula I are described, in which A is CHOH and CHCl, CH2, C=O or 9(11) double bond; Y is H, F or Cl; Z is H, F or methyl; R(1) is aryl or hetaryl; R(2) is alkyl and R(3) is H or methyl. They are obtained, inter alia, by reacting a compound of the formula II, in which R(S) is OH, with an activated carboxylic acid of the formula III, R(6)-CO-(O)n(C1-C4)-alkyl]m-R(1) III. They have a very strong local and topical antiinflamma-tory action and exhibit a very good ratio of local to systemic antiinflammatory effects. They are used, inter alia, as agents for treating inflammatory dermatoses.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS |
| title | CORTICOID -17,21-DICARBOXYLIC ESTERS AND CORTICOSTEROID 17-CABOXYLIC ESTERS 21-CARBONIC ESTERS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS |
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