ENHANCED TRIPLE-HELIX AND DOUBLE-HELIX FORMATION WITH OLIGOMERS CONTAINING MODIFIED PYRIMIDINES

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capa...

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Bibliographische Detailangaben
Hauptverfasser: GUTIERREZ, ARNOLD J, PUDLO, JEFF, FROEHLER, BRIAN, MATTEUCCI, MARK, WAGNER, RICK, JONES, ROBERT J
Format: Patent
Sprache:eng ; fre
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