OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES
OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES Disclosed are oligonucleoside boranophosphates, or salts thereof, comprising a chain of natural or modified ribonucleotides or deoxyribonucleotides, containing at least one boronated internucleotide phospodiester linkage of the formul...
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| creator | SHAW, BARBARA R SPIELVOGEL BERNARD F SOOD, ANUP HALL, IRIS H |
| description | OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES Disclosed are oligonucleoside boranophosphates, or salts thereof, comprising a chain of natural or modified ribonucleotides or deoxyribonucleotides, containing at least one boronated internucleotide phospodiester linkage of the formula: (III) W is selected from the group consisting of =O, =S, -OPr, and -SPr where Pr is a base-labile protecting group. X is selected from the group consisting of -BH3, -BH2R1, -BHR1R2 and -BR1R2R3. R1 is selected from the group consisting of -R4, -COOH, -COOR4, -CONHR4, -CON(R4)2, -CN+R4, -CN, carboxycholesteryl and carboxybenzyl, wherein R4 is C1 to C18 alkyl. R2 is selected from the group consisting of -R3, -COOH, -COOR5, -CONHR5, -CON(R5)2, -CN+R5, -CN, carboxy- cholesteryl and carboxybenzyl, wherein R5 is C1 to C18 alkyl. R3 is selected from the group consisting of C1 to C3 alkyl. Most preferably, X is -BH3 and W is =O. Compounds of Formula (III) are useful as antisense agents and probes in molecular biology, and have pharmacological activities including anti-inflammatory, antihyperlipidemic, and antineoplastic activity. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA2069905A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA2069905A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA2069905A13</originalsourceid><addsrcrecordid>eNrjZHD09_F09w_ydPL3C3X2cfUP9nRxVXD0c1EAi7u4-kdEokk6-Qc5-vkHePgHB3g4hrgG8zCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSSeGdHIwMzS0sDU0dDYyKUAADkRitK</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES</title><source>esp@cenet</source><creator>SHAW, BARBARA R ; SPIELVOGEL BERNARD F ; SOOD, ANUP ; HALL, IRIS H</creator><creatorcontrib>SHAW, BARBARA R ; SPIELVOGEL BERNARD F ; SOOD, ANUP ; HALL, IRIS H</creatorcontrib><description>OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES Disclosed are oligonucleoside boranophosphates, or salts thereof, comprising a chain of natural or modified ribonucleotides or deoxyribonucleotides, containing at least one boronated internucleotide phospodiester linkage of the formula: (III) W is selected from the group consisting of =O, =S, -OPr, and -SPr where Pr is a base-labile protecting group. X is selected from the group consisting of -BH3, -BH2R1, -BHR1R2 and -BR1R2R3. R1 is selected from the group consisting of -R4, -COOH, -COOR4, -CONHR4, -CON(R4)2, -CN+R4, -CN, carboxycholesteryl and carboxybenzyl, wherein R4 is C1 to C18 alkyl. R2 is selected from the group consisting of -R3, -COOH, -COOR5, -CONHR5, -CON(R5)2, -CN+R5, -CN, carboxy- cholesteryl and carboxybenzyl, wherein R5 is C1 to C18 alkyl. R3 is selected from the group consisting of C1 to C3 alkyl. Most preferably, X is -BH3 and W is =O. Compounds of Formula (III) are useful as antisense agents and probes in molecular biology, and have pharmacological activities including anti-inflammatory, antihyperlipidemic, and antineoplastic activity.</description><edition>5</edition><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; DERIVATIVES THEREOF ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910531&DB=EPODOC&CC=CA&NR=2069905A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910531&DB=EPODOC&CC=CA&NR=2069905A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHAW, BARBARA R</creatorcontrib><creatorcontrib>SPIELVOGEL BERNARD F</creatorcontrib><creatorcontrib>SOOD, ANUP</creatorcontrib><creatorcontrib>HALL, IRIS H</creatorcontrib><title>OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES</title><description>OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES Disclosed are oligonucleoside boranophosphates, or salts thereof, comprising a chain of natural or modified ribonucleotides or deoxyribonucleotides, containing at least one boronated internucleotide phospodiester linkage of the formula: (III) W is selected from the group consisting of =O, =S, -OPr, and -SPr where Pr is a base-labile protecting group. X is selected from the group consisting of -BH3, -BH2R1, -BHR1R2 and -BR1R2R3. R1 is selected from the group consisting of -R4, -COOH, -COOR4, -CONHR4, -CON(R4)2, -CN+R4, -CN, carboxycholesteryl and carboxybenzyl, wherein R4 is C1 to C18 alkyl. R2 is selected from the group consisting of -R3, -COOH, -COOR5, -CONHR5, -CON(R5)2, -CN+R5, -CN, carboxy- cholesteryl and carboxybenzyl, wherein R5 is C1 to C18 alkyl. R3 is selected from the group consisting of C1 to C3 alkyl. Most preferably, X is -BH3 and W is =O. Compounds of Formula (III) are useful as antisense agents and probes in molecular biology, and have pharmacological activities including anti-inflammatory, antihyperlipidemic, and antineoplastic activity.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1991</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD09_F09w_ydPL3C3X2cfUP9nRxVXD0c1EAi7u4-kdEokk6-Qc5-vkHePgHB3g4hrgG8zCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSSeGdHIwMzS0sDU0dDYyKUAADkRitK</recordid><startdate>19910531</startdate><enddate>19910531</enddate><creator>SHAW, BARBARA R</creator><creator>SPIELVOGEL BERNARD F</creator><creator>SOOD, ANUP</creator><creator>HALL, IRIS H</creator><scope>EVB</scope></search><sort><creationdate>19910531</creationdate><title>OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES</title><author>SHAW, BARBARA R ; SPIELVOGEL BERNARD F ; SOOD, ANUP ; HALL, IRIS H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA2069905A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1991</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SHAW, BARBARA R</creatorcontrib><creatorcontrib>SPIELVOGEL BERNARD F</creatorcontrib><creatorcontrib>SOOD, ANUP</creatorcontrib><creatorcontrib>HALL, IRIS H</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHAW, BARBARA R</au><au>SPIELVOGEL BERNARD F</au><au>SOOD, ANUP</au><au>HALL, IRIS H</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES</title><date>1991-05-31</date><risdate>1991</risdate><abstract>OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES Disclosed are oligonucleoside boranophosphates, or salts thereof, comprising a chain of natural or modified ribonucleotides or deoxyribonucleotides, containing at least one boronated internucleotide phospodiester linkage of the formula: (III) W is selected from the group consisting of =O, =S, -OPr, and -SPr where Pr is a base-labile protecting group. X is selected from the group consisting of -BH3, -BH2R1, -BHR1R2 and -BR1R2R3. R1 is selected from the group consisting of -R4, -COOH, -COOR4, -CONHR4, -CON(R4)2, -CN+R4, -CN, carboxycholesteryl and carboxybenzyl, wherein R4 is C1 to C18 alkyl. R2 is selected from the group consisting of -R3, -COOH, -COOR5, -CONHR5, -CON(R5)2, -CN+R5, -CN, carboxy- cholesteryl and carboxybenzyl, wherein R5 is C1 to C18 alkyl. R3 is selected from the group consisting of C1 to C3 alkyl. Most preferably, X is -BH3 and W is =O. Compounds of Formula (III) are useful as antisense agents and probes in molecular biology, and have pharmacological activities including anti-inflammatory, antihyperlipidemic, and antineoplastic activity.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE |
| title | OLIGORIBONUCLEOSIDE AND OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES |
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