NAPHTHALENE DERIVATIVES
Novel naphthalene derivatives and pharmacologically acceptable salts thereof, having excellent anti-inflammatory activity, are disclosed. The naphthalene derivatives fall within the general formula: (I) wherein R1 stands for a hydrogen atom or a lower alkyl, acyl or arylalkyl group; R2 stands for a...
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| creator | YAMATSU, ISAO MIYAZAWA, SHUHEI HARADA, KOUKICHI OKANO, KAZUO CHIBA, KENICHI HORIE, TORU MORI, TAKASHI YOSHIMURA, HIROYUKI HASHIDA, RYOICHI MURAMOTO, KENZO SHIROTA, HIROSHI KUSUBE, KENICHI INOUE, TAKASHI CLARK, RICHARD, S. J KAWAHARA, TETSUYA ABE, SHINYA SHIMOMURA, NAOYUKI SUZUKI, TAKESHI |
| description | Novel naphthalene derivatives and pharmacologically acceptable salts thereof, having excellent anti-inflammatory activity, are disclosed. The naphthalene derivatives fall within the general formula: (I) wherein R1 stands for a hydrogen atom or a lower alkyl, acyl or arylalkyl group; R2 stands for a hydrogen atom or a lower alkyl, lower alkoxy, cycloalkoxy or acyl group; R3 stands for a hydroxyl group, an ester-forming group or an amine; R4 stands for a hydrogen atom, a lower alkyl group or a group represented by the formula: (wherein p is 0 or an integer 1 to 3, and R12 stands for a hydrogen or halogen atom or a lower alkyl or lower alkoxy group); z stands for a group represented by the formula: (wherein R5 and R6 may be the same or different from each other and each stands, by way of example, for a hydrogen atom or a lower alkyl group), a group represented by the formula: =N-OR7 (wherein R7 stands for a lower alkyl group) or an oxygen atom; and Y stands for a group represented by the formula: -(CH2)n- (wherein n is 0 or an integer 1 or 2) or a group represented by the formula: (wherein R8 and R9 may be the same or different from each other and each stands for a lower alkyl group). |
| format | Patent |
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J ; KAWAHARA, TETSUYA ; ABE, SHINYA ; SHIMOMURA, NAOYUKI ; SUZUKI, TAKESHI</creator><creatorcontrib>YAMATSU, ISAO ; MIYAZAWA, SHUHEI ; HARADA, KOUKICHI ; OKANO, KAZUO ; CHIBA, KENICHI ; HORIE, TORU ; MORI, TAKASHI ; YOSHIMURA, HIROYUKI ; HASHIDA, RYOICHI ; MURAMOTO, KENZO ; SHIROTA, HIROSHI ; KUSUBE, KENICHI ; INOUE, TAKASHI ; CLARK, RICHARD, S. J ; KAWAHARA, TETSUYA ; ABE, SHINYA ; SHIMOMURA, NAOYUKI ; SUZUKI, TAKESHI</creatorcontrib><description>Novel naphthalene derivatives and pharmacologically acceptable salts thereof, having excellent anti-inflammatory activity, are disclosed. The naphthalene derivatives fall within the general formula: (I) wherein R1 stands for a hydrogen atom or a lower alkyl, acyl or arylalkyl group; R2 stands for a hydrogen atom or a lower alkyl, lower alkoxy, cycloalkoxy or acyl group; R3 stands for a hydroxyl group, an ester-forming group or an amine; R4 stands for a hydrogen atom, a lower alkyl group or a group represented by the formula: (wherein p is 0 or an integer 1 to 3, and R12 stands for a hydrogen or halogen atom or a lower alkyl or lower alkoxy group); z stands for a group represented by the formula: (wherein R5 and R6 may be the same or different from each other and each stands, by way of example, for a hydrogen atom or a lower alkyl group), a group represented by the formula: =N-OR7 (wherein R7 stands for a lower alkyl group) or an oxygen atom; and Y stands for a group represented by the formula: -(CH2)n- (wherein n is 0 or an integer 1 or 2) or a group represented by the formula: (wherein R8 and R9 may be the same or different from each other and each stands for a lower alkyl group).</description><edition>5</edition><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1992</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920517&DB=EPODOC&CC=CA&NR=2055630A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920517&DB=EPODOC&CC=CA&NR=2055630A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YAMATSU, ISAO</creatorcontrib><creatorcontrib>MIYAZAWA, SHUHEI</creatorcontrib><creatorcontrib>HARADA, KOUKICHI</creatorcontrib><creatorcontrib>OKANO, KAZUO</creatorcontrib><creatorcontrib>CHIBA, KENICHI</creatorcontrib><creatorcontrib>HORIE, TORU</creatorcontrib><creatorcontrib>MORI, TAKASHI</creatorcontrib><creatorcontrib>YOSHIMURA, HIROYUKI</creatorcontrib><creatorcontrib>HASHIDA, RYOICHI</creatorcontrib><creatorcontrib>MURAMOTO, KENZO</creatorcontrib><creatorcontrib>SHIROTA, HIROSHI</creatorcontrib><creatorcontrib>KUSUBE, KENICHI</creatorcontrib><creatorcontrib>INOUE, TAKASHI</creatorcontrib><creatorcontrib>CLARK, RICHARD, S. 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The naphthalene derivatives fall within the general formula: (I) wherein R1 stands for a hydrogen atom or a lower alkyl, acyl or arylalkyl group; R2 stands for a hydrogen atom or a lower alkyl, lower alkoxy, cycloalkoxy or acyl group; R3 stands for a hydroxyl group, an ester-forming group or an amine; R4 stands for a hydrogen atom, a lower alkyl group or a group represented by the formula: (wherein p is 0 or an integer 1 to 3, and R12 stands for a hydrogen or halogen atom or a lower alkyl or lower alkoxy group); z stands for a group represented by the formula: (wherein R5 and R6 may be the same or different from each other and each stands, by way of example, for a hydrogen atom or a lower alkyl group), a group represented by the formula: =N-OR7 (wherein R7 stands for a lower alkyl group) or an oxygen atom; and Y stands for a group represented by the formula: -(CH2)n- (wherein n is 0 or an integer 1 or 2) or a group represented by the formula: (wherein R8 and R9 may be the same or different from each other and each stands for a lower alkyl group).</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1992</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD3cwzwCPFw9HH1c1VwcQ3yDHMM8QxzDeZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfHOjkYGpqZmxgaOhsZEKAEAoFwe_A</recordid><startdate>19920517</startdate><enddate>19920517</enddate><creator>YAMATSU, ISAO</creator><creator>MIYAZAWA, SHUHEI</creator><creator>HARADA, KOUKICHI</creator><creator>OKANO, KAZUO</creator><creator>CHIBA, KENICHI</creator><creator>HORIE, TORU</creator><creator>MORI, TAKASHI</creator><creator>YOSHIMURA, HIROYUKI</creator><creator>HASHIDA, RYOICHI</creator><creator>MURAMOTO, KENZO</creator><creator>SHIROTA, HIROSHI</creator><creator>KUSUBE, KENICHI</creator><creator>INOUE, TAKASHI</creator><creator>CLARK, RICHARD, S. 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J</au><au>KAWAHARA, TETSUYA</au><au>ABE, SHINYA</au><au>SHIMOMURA, NAOYUKI</au><au>SUZUKI, TAKESHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NAPHTHALENE DERIVATIVES</title><date>1992-05-17</date><risdate>1992</risdate><abstract>Novel naphthalene derivatives and pharmacologically acceptable salts thereof, having excellent anti-inflammatory activity, are disclosed. The naphthalene derivatives fall within the general formula: (I) wherein R1 stands for a hydrogen atom or a lower alkyl, acyl or arylalkyl group; R2 stands for a hydrogen atom or a lower alkyl, lower alkoxy, cycloalkoxy or acyl group; R3 stands for a hydroxyl group, an ester-forming group or an amine; R4 stands for a hydrogen atom, a lower alkyl group or a group represented by the formula: (wherein p is 0 or an integer 1 to 3, and R12 stands for a hydrogen or halogen atom or a lower alkyl or lower alkoxy group); z stands for a group represented by the formula: (wherein R5 and R6 may be the same or different from each other and each stands, by way of example, for a hydrogen atom or a lower alkyl group), a group represented by the formula: =N-OR7 (wherein R7 stands for a lower alkyl group) or an oxygen atom; and Y stands for a group represented by the formula: -(CH2)n- (wherein n is 0 or an integer 1 or 2) or a group represented by the formula: (wherein R8 and R9 may be the same or different from each other and each stands for a lower alkyl group).</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NAPHTHALENE DERIVATIVES |
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