ACRYLOYL SUBSTITUTED PYRROLE DERIVATIVES

The invention relates to acryloyl substituted pyrrole derivatives of formula (I) (see formula I) wherein n is an integer of 1 to 5; each of R1 and R2, which may be the same or different, is hydrogen, halogen, CN, -NO2, C1-C4 alkyl, or a group (see formula II) R3 is hydrogen, halogen, -CN, or NO2; each R4 is, independently, hydrogen or C1-C4 alkyl; A is a bond, a group (see formula III) ,or a group NH-Het-CO-, wherein Het is a saturated or unsaturated pentatomic or hexatomic heteromonocyclic ring; and (see formula IV), or B is a group (see formula V) in which m is 1, 2 or 3 and each R5 is, independently, a C1C4 alkyl group; and pharmaceutically acceptable salts thereof, which are useful as antineoplastic agents.