EXPRESSION AND SECRETION OF MATURE HUMAN BETA INTERLEUKIN-1 IN BACILLUS SUBTILIS AND MEANS AND METHODS FOR ITS ACHIEVEMENT

EXPRESSION AND SECRETION OF MATURE HUMAN BETA INTERLEUKIN-1 IN BACILLUS SUBTILIS AND MEANS AND METHODS FOR ITS ACHIEVEMENT

28 A new plasmid vector is described which can replicate in B.subtilis and which can express and secrete, in the culture medium, human beta interleukin-1 (beta IL-1) without amino acid sequences extraneous to the natural molecule, a strain of B.subtilis transformed by the vector and a method for the...

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Bibliographische Detailangaben
Hauptverfasser: GRANDI, GUIDO, GALLI, GIULIANO, LUCCHESE, GIUSEPPE, VELATI BELLINI, ADA
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Zusammenfassung:28 A new plasmid vector is described which can replicate in B.subtilis and which can express and secrete, in the culture medium, human beta interleukin-1 (beta IL-1) without amino acid sequences extraneous to the natural molecule, a strain of B.subtilis transformed by the vector and a method for the expression and secretion of mature human beta interleukin-l. The human beta interleukin-l thus obtained shows a specific acitvity of 1 x 109 U/mg of protein and is particularly suitable as a stimulant for the immune system, as an adjuvant in vaccines for the activation of the repair mechanism in cases of tissue damage, and for the treatment of auto-immune diseases in man.