PROCESS FOR THE PREPARATION OF RANITIDINE OR ACID ADDITION SALTS THEREOF

PROCESS FOR THE PREPARATION OF RANITIDINE OR ACID ADDITION SALTS THEREOF

Ranitidine, which has the formula (I) is prepared by reaction of N-¢2-¢¢¢5-(hydroxymethyl)-2-furanyl!methyl!thio!ethyl!-N'-methyl-2-nitro-1,1-ethene-diamine, which has the formula (V) in an organic solvent, e.g. dimethylformamide, with dimethylamine and an N,N-(dimethylamino)-triphosphonium-hal...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: ALHEDE, B/RGE, CLAUSEN, FINN P
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Ranitidine, which has the formula (I) is prepared by reaction of N-¢2-¢¢¢5-(hydroxymethyl)-2-furanyl!methyl!thio!ethyl!-N'-methyl-2-nitro-1,1-ethene-diamine, which has the formula (V) in an organic solvent, e.g. dimethylformamide, with dimethylamine and an N,N-(dimethylamino)-triphosphonium-halide having the formula wherein Hal denotes bromo or chloro.