PHYSIOLOGICALLY ACTIVE COMPOSITIONS

It has previously been shown that bivalent antibodies to insulin can mimic the action of insulin in vivo. However antibodies in vivo were believed to have the opposite effect. It has now been found that the administration to vertebrates of certain specific anti-hormone antibodies, preferably monoclo...

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Hauptverfasser:	ASTON, ROGER, IVANYI, JURAJ, HOLDER, ANDREW T
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	ASTON, ROGER IVANYI, JURAJ HOLDER, ANDREW T
description	It has previously been shown that bivalent antibodies to insulin can mimic the action of insulin in vivo. However antibodies in vivo were believed to have the opposite effect. It has now been found that the administration to vertebrates of certain specific anti-hormone antibodies, preferably monoclonal antibodies, with or without administration of the hormone itself, can potentiate the biological action of the hormone. Active immunisation with a fragment of the hormone can also be carried out. Such methods can be used therapeutically or alternatively to increase the response of the vertebrate to the hormone beyond normal physiological levels. When the hormone is growth hormone, accelerated growth of economically important animals can be achieved.
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When the hormone is growth hormone, accelerated growth of economically important animals can be achieved.</description><edition>4</edition><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890926&DB=EPODOC&CC=CA&NR=1259923A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890926&DB=EPODOC&CC=CA&NR=1259923A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ASTON, ROGER</creatorcontrib><creatorcontrib>IVANYI, JURAJ</creatorcontrib><creatorcontrib>HOLDER, ANDREW T</creatorcontrib><title>PHYSIOLOGICALLY ACTIVE COMPOSITIONS</title><description>It has previously been shown that bivalent antibodies to insulin can mimic the action of insulin in vivo. However antibodies in vivo were believed to have the opposite effect. It has now been found that the administration to vertebrates of certain specific anti-hormone antibodies, preferably monoclonal antibodies, with or without administration of the hormone itself, can potentiate the biological action of the hormone. Active immunisation with a fragment of the hormone can also be carried out. Such methods can be used therapeutically or alternatively to increase the response of the vertebrate to the hormone beyond normal physiological levels. When the hormone is growth hormone, accelerated growth of economically important animals can be achieved.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAO8IgM9vT38Xf3dHb08YlUcHQO8QxzVXD29w3wD_YM8fT3C-ZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOjoZGppaWRsaOxoRVAAACViJJ</recordid><startdate>19890926</startdate><enddate>19890926</enddate><creator>ASTON, ROGER</creator><creator>IVANYI, JURAJ</creator><creator>HOLDER, ANDREW T</creator><scope>EVB</scope></search><sort><creationdate>19890926</creationdate><title>PHYSIOLOGICALLY ACTIVE COMPOSITIONS</title><author>ASTON, ROGER ; IVANYI, JURAJ ; HOLDER, ANDREW T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA1259923A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1989</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>ASTON, ROGER</creatorcontrib><creatorcontrib>IVANYI, JURAJ</creatorcontrib><creatorcontrib>HOLDER, ANDREW T</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ASTON, ROGER</au><au>IVANYI, JURAJ</au><au>HOLDER, ANDREW T</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PHYSIOLOGICALLY ACTIVE COMPOSITIONS</title><date>1989-09-26</date><risdate>1989</risdate><abstract>It has previously been shown that bivalent antibodies to insulin can mimic the action of insulin in vivo. 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subjects	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	PHYSIOLOGICALLY ACTIVE COMPOSITIONS
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