MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF ANTHRACYCLINE DERIVATIVES
of the disclosure: The present application relates to a microbiological process for the preparation of compounds of the formula I I in which R denotes hydrogen or hydroxyl and R1 and R2 are identical or different and represent sugar combinations of the following composition: - Roa-dF-CinA - Roa-dF-A...
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| creator | ARETZ, WERNER KRAEMER, HANS P HUBER, GERHARD BERSCHEID, HANS G FEHLHABER, HANS-WOLFRAM |
| description | of the disclosure: The present application relates to a microbiological process for the preparation of compounds of the formula I I in which R denotes hydrogen or hydroxyl and R1 and R2 are identical or different and represent sugar combinations of the following composition: - Roa-dF-CinA - Roa-dF-Acu - Roa-dF=CinB - Roa-Rod-CinA or - Roa-Rod-Acu or R2 has the abovementioned meanings and R1 represents sugar combinations of the following composition: - Roa-dF-Rod - Roa-dF-CinB - Roa-dF-Acu - Roa-Rod-Acu - Roa-dF-CinA - Roa-Rod-Rod or - Roa-Rod-CinA in which Roa denotes rhodosamine; dF denotes deoxyfucose; Rod denotes rhodinose; Acu denotes aculose; CinA denotes cinerulose A and CinB denotes cinerulose B, and dF = CinB means that the two sugar units deoxyfucose and cinerulose B are linked by an extra ether bridge, in addition to the usual glycosidic bond, which comprises reacting a compound of the formula II II in which R denotes hydrogen or hydroxyl and R3 and R4 are identical or different and represent sugar combinations of the following composition: -Roa-dF-Rod -Roa-Rod-Rod -Roa-dF-CinA or -Roa-Rod-CinA or only R3 or only R4 has the meanings given and the other substituent in each case denotes -Roa-dF-Rod -Roa-dF=CinB -Roa-dF-Acu -Roa-Rod-Acu -Roa-dF-CinA -Roa-Rod-Rod or -Roa-Rod-CinA with a specific oxidoreductase, isolating the resulting compound from the reaction medium by extraction in a manner which is known per se and purifying the product. |
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dF denotes deoxyfucose; Rod denotes rhodinose; Acu denotes aculose; CinA denotes cinerulose A and CinB denotes cinerulose B, and dF = CinB means that the two sugar units deoxyfucose and cinerulose B are linked by an extra ether bridge, in addition to the usual glycosidic bond, which comprises reacting a compound of the formula II II in which R denotes hydrogen or hydroxyl and R3 and R4 are identical or different and represent sugar combinations of the following composition: -Roa-dF-Rod -Roa-Rod-Rod -Roa-dF-CinA or -Roa-Rod-CinA or only R3 or only R4 has the meanings given and the other substituent in each case denotes -Roa-dF-Rod -Roa-dF=CinB -Roa-dF-Acu -Roa-Rod-Acu -Roa-dF-CinA -Roa-Rod-Rod or -Roa-Rod-CinA with a specific oxidoreductase, isolating the resulting compound from the reaction medium by extraction in a manner which is known per se and purifying the product.</description><edition>4</edition><language>eng ; fre</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; METALLURGY ; 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dF denotes deoxyfucose; Rod denotes rhodinose; Acu denotes aculose; CinA denotes cinerulose A and CinB denotes cinerulose B, and dF = CinB means that the two sugar units deoxyfucose and cinerulose B are linked by an extra ether bridge, in addition to the usual glycosidic bond, which comprises reacting a compound of the formula II II in which R denotes hydrogen or hydroxyl and R3 and R4 are identical or different and represent sugar combinations of the following composition: -Roa-dF-Rod -Roa-Rod-Rod -Roa-dF-CinA or -Roa-Rod-CinA or only R3 or only R4 has the meanings given and the other substituent in each case denotes -Roa-dF-Rod -Roa-dF=CinB -Roa-dF-Acu -Roa-Rod-Acu -Roa-dF-CinA -Roa-Rod-Rod or -Roa-Rod-CinA with a specific oxidoreductase, isolating the resulting compound from the reaction medium by extraction in a manner which is known per se and purifying the product.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1988</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPDw9XQO8nfy9Pfxd_d0dvRRCAjyd3YNDlZw8w9SCPFwBfJdAxyDHEM8_f0U_N0UHP1CPIIcnSOdfTz9XBVcXIM8w4ByYa7BPAysaYk5xam8UJqbQd7NNcTZQze1ID8-tbggMTk1L7Uk3tnR0MjE3MDIwtGYsAoAe5gsPA</recordid><startdate>19881220</startdate><enddate>19881220</enddate><creator>ARETZ, WERNER</creator><creator>KRAEMER, HANS P</creator><creator>HUBER, GERHARD</creator><creator>BERSCHEID, HANS G</creator><creator>FEHLHABER, HANS-WOLFRAM</creator><scope>EVB</scope></search><sort><creationdate>19881220</creationdate><title>MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF ANTHRACYCLINE DERIVATIVES</title><author>ARETZ, WERNER ; KRAEMER, HANS P ; HUBER, GERHARD ; BERSCHEID, HANS G ; FEHLHABER, HANS-WOLFRAM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA1247028A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1988</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>ARETZ, WERNER</creatorcontrib><creatorcontrib>KRAEMER, HANS P</creatorcontrib><creatorcontrib>HUBER, GERHARD</creatorcontrib><creatorcontrib>BERSCHEID, HANS G</creatorcontrib><creatorcontrib>FEHLHABER, HANS-WOLFRAM</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ARETZ, WERNER</au><au>KRAEMER, HANS P</au><au>HUBER, GERHARD</au><au>BERSCHEID, HANS G</au><au>FEHLHABER, HANS-WOLFRAM</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF ANTHRACYCLINE DERIVATIVES</title><date>1988-12-20</date><risdate>1988</risdate><abstract>of the disclosure: The present application relates to a microbiological process for the preparation of compounds of the formula I I in which R denotes hydrogen or hydroxyl and R1 and R2 are identical or different and represent sugar combinations of the following composition: - Roa-dF-CinA - Roa-dF-Acu - Roa-dF=CinB - Roa-Rod-CinA or - Roa-Rod-Acu or R2 has the abovementioned meanings and R1 represents sugar combinations of the following composition: - Roa-dF-Rod - Roa-dF-CinB - Roa-dF-Acu - Roa-Rod-Acu - Roa-dF-CinA - Roa-Rod-Rod or - Roa-Rod-CinA in which Roa denotes rhodosamine; dF denotes deoxyfucose; Rod denotes rhodinose; Acu denotes aculose; CinA denotes cinerulose A and CinB denotes cinerulose B, and dF = CinB means that the two sugar units deoxyfucose and cinerulose B are linked by an extra ether bridge, in addition to the usual glycosidic bond, which comprises reacting a compound of the formula II II in which R denotes hydrogen or hydroxyl and R3 and R4 are identical or different and represent sugar combinations of the following composition: -Roa-dF-Rod -Roa-Rod-Rod -Roa-dF-CinA or -Roa-Rod-CinA or only R3 or only R4 has the meanings given and the other substituent in each case denotes -Roa-dF-Rod -Roa-dF=CinB -Roa-dF-Acu -Roa-Rod-Acu -Roa-dF-CinA -Roa-Rod-Rod or -Roa-Rod-CinA with a specific oxidoreductase, isolating the resulting compound from the reaction medium by extraction in a manner which is known per se and purifying the product.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS |
| title | MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF ANTHRACYCLINE DERIVATIVES |
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