NICOTINIC DERIVATIVES OF GLUCOSAMINE, PROCESS FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS

NICOTINIC DERIVATIVES OF GLUCOSAMINE, PROCESS FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS

Nicotinic derivatives of glucosamine, particularly N-nicotinoyl-glucosamine tetranicotinate have useful antilipolitic, hypocholesterolemizing and anti-aterogenic activities, at a like or higher level than those of nicotinic acid, without the objectionable side effects as shown by the acid. For the p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MURMANN, WALTER, PONCHIROLI, OSVALDO
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:Nicotinic derivatives of glucosamine, particularly N-nicotinoyl-glucosamine tetranicotinate have useful antilipolitic, hypocholesterolemizing and anti-aterogenic activities, at a like or higher level than those of nicotinic acid, without the objectionable side effects as shown by the acid. For the preparation of the compounds of the invention nicotinoyl chloride hydrochloride and glucosamine hydrochloride are reacted in an organic solvent at a temperature of between 40.degree.C and 120.degree.C.