1-AMINO-3-ARYLOXY-2-PROPANOLS
Compounds of formula I wherein (i) m is o, n is 2 and p is 1 or (ii) m is o or 1, n is 1, and p is 1 or (iii) m is 1, n is 1 or 2 and p is o, R1 is (i) alkyl of 3 to 7 carbon atoms or (ii) phenylalkyl, phenoxyalkyl, phenylthioalkyl of 8 to 11 carbon atoms in the aggregate thereof and wherein the phe...
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| creator | BERTHOLD, RICHARD PAYNE, TREVOR G |
| description | Compounds of formula I wherein (i) m is o, n is 2 and p is 1 or (ii) m is o or 1, n is 1, and p is 1 or (iii) m is 1, n is 1 or 2 and p is o, R1 is (i) alkyl of 3 to 7 carbon atoms or (ii) phenylalkyl, phenoxyalkyl, phenylthioalkyl of 8 to 11 carbon atoms in the aggregate thereof and wherein the phenyl ring is separated by at least 2 carbon atoms from the nitrogen atoms to which R1 is bound and wherein the phenyl ring is unsubstituted, or mono-substituted by, or independently disubstituted by, alkyl or alkoxy of 1 to 4 carbon atoms, halogen of atomic number from 9 to 35. trifluoromethyl or cyano, R2 and R3 are either together straight chain alkylene of 4 to 6 carbon atoms. or, independently, hydrogen or alkyl of 1 to 4 carbon atoms, with the proviso that when m is 1, n is 1 and p is O then least one of R2 and R3 is other than hydrogen, and R4 and R5 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, are useful in the treatment of coronary disorders. |
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fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1982</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19820302&DB=EPODOC&CC=CA&NR=1119190A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19820302&DB=EPODOC&CC=CA&NR=1119190A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BERTHOLD, RICHARD</creatorcontrib><creatorcontrib>PAYNE, TREVOR G</creatorcontrib><title>1-AMINO-3-ARYLOXY-2-PROPANOLS</title><description>Compounds of formula I wherein (i) m is o, n is 2 and p is 1 or (ii) m is o or 1, n is 1, and p is 1 or (iii) m is 1, n is 1 or 2 and p is o, R1 is (i) alkyl of 3 to 7 carbon atoms or (ii) phenylalkyl, phenoxyalkyl, phenylthioalkyl of 8 to 11 carbon atoms in the aggregate thereof and wherein the phenyl ring is separated by at least 2 carbon atoms from the nitrogen atoms to which R1 is bound and wherein the phenyl ring is unsubstituted, or mono-substituted by, or independently disubstituted by, alkyl or alkoxy of 1 to 4 carbon atoms, halogen of atomic number from 9 to 35. trifluoromethyl or cyano, R2 and R3 are either together straight chain alkylene of 4 to 6 carbon atoms. or, independently, hydrogen or alkyl of 1 to 4 carbon atoms, with the proviso that when m is 1, n is 1 and p is O then least one of R2 and R3 is other than hydrogen, and R4 and R5 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, are useful in the treatment of coronary disorders.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1982</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJA11HX09fTz1zXWdQyK9PGPiNQ10g0I8g9w9PP3CeZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHOjoaGhpaGlgaOxoRVAAD7xx_z</recordid><startdate>19820302</startdate><enddate>19820302</enddate><creator>BERTHOLD, RICHARD</creator><creator>PAYNE, TREVOR G</creator><scope>EVB</scope></search><sort><creationdate>19820302</creationdate><title>1-AMINO-3-ARYLOXY-2-PROPANOLS</title><author>BERTHOLD, RICHARD ; PAYNE, TREVOR G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA1119190A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1982</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BERTHOLD, RICHARD</creatorcontrib><creatorcontrib>PAYNE, TREVOR G</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BERTHOLD, RICHARD</au><au>PAYNE, TREVOR G</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>1-AMINO-3-ARYLOXY-2-PROPANOLS</title><date>1982-03-02</date><risdate>1982</risdate><abstract>Compounds of formula I wherein (i) m is o, n is 2 and p is 1 or (ii) m is o or 1, n is 1, and p is 1 or (iii) m is 1, n is 1 or 2 and p is o, R1 is (i) alkyl of 3 to 7 carbon atoms or (ii) phenylalkyl, phenoxyalkyl, phenylthioalkyl of 8 to 11 carbon atoms in the aggregate thereof and wherein the phenyl ring is separated by at least 2 carbon atoms from the nitrogen atoms to which R1 is bound and wherein the phenyl ring is unsubstituted, or mono-substituted by, or independently disubstituted by, alkyl or alkoxy of 1 to 4 carbon atoms, halogen of atomic number from 9 to 35. trifluoromethyl or cyano, R2 and R3 are either together straight chain alkylene of 4 to 6 carbon atoms. or, independently, hydrogen or alkyl of 1 to 4 carbon atoms, with the proviso that when m is 1, n is 1 and p is O then least one of R2 and R3 is other than hydrogen, and R4 and R5 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, are useful in the treatment of coronary disorders.</abstract><edition>3</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 1-AMINO-3-ARYLOXY-2-PROPANOLS |
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