INDUSTRIAL METHOD FOR PRODUCING A1-TERT.-BUTYLAMINO-METHYL-4-HYDROXY-M-XYLENE-A1,A3-DIOLE

INDUSTRIAL METHOD FOR PRODUCING A1-TERT.-BUTYLAMINO-METHYL-4-HYDROXY-M-XYLENE-A1,A3-DIOLE

The present invention relates to a method for producing therapeutically valuable .alpha.2-tert.-butylaminomethyl-4-hydroxy-m-xylene-.alpha.2 ,.alpha.3-diole, which has the formula and its acid addition salts, characterized in that an imine derivative having the formula where R stands for a lower str...

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1. Verfasser: RUOHONEN, JARKKO
Format: Patent
Sprache:eng ; fre
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator RUOHONEN, JARKKO
description The present invention relates to a method for producing therapeutically valuable .alpha.2-tert.-butylaminomethyl-4-hydroxy-m-xylene-.alpha.2 ,.alpha.3-diole, which has the formula and its acid addition salts, characterized in that an imine derivative having the formula where R stands for a lower straight-chain or branched hydrocarbon radical containing 1 to 6 carbon atoms, and Ar stands for an aryl group, is converted by simultaneous hydrogenation and reduction into a compound having the formula and from which the arylmethyl protective group is removed by catalytic hydration. The method, according to the invention, is appropriate for industrial production work wherein .alpha.2-tert.-buty-laminomethyl-4-hydroxy-m-xylene-.alpha.1,.alpha.3-diole can be easily produced with a good yield in a continuous process, without isolating the intermediate products.
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The method, according to the invention, is appropriate for industrial production work wherein .alpha.2-tert.-buty-laminomethyl-4-hydroxy-m-xylene-.alpha.1,.alpha.3-diole can be easily produced with a good yield in a continuous process, without isolating the intermediate products.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1978</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19781017&amp;DB=EPODOC&amp;CC=CA&amp;NR=1040658A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19781017&amp;DB=EPODOC&amp;CC=CA&amp;NR=1040658A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RUOHONEN, JARKKO</creatorcontrib><title>INDUSTRIAL METHOD FOR PRODUCING A1-TERT.-BUTYLAMINO-METHYL-4-HYDROXY-M-XYLENE-A1,A3-DIOLE</title><description>The present invention relates to a method for producing therapeutically valuable .alpha.2-tert.-butylaminomethyl-4-hydroxy-m-xylene-.alpha.2 ,.alpha.3-diole, which has the formula and its acid addition salts, characterized in that an imine derivative having the formula where R stands for a lower straight-chain or branched hydrocarbon radical containing 1 to 6 carbon atoms, and Ar stands for an aryl group, is converted by simultaneous hydrogenation and reduction into a compound having the formula and from which the arylmethyl protective group is removed by catalytic hydration. The method, according to the invention, is appropriate for industrial production work wherein .alpha.2-tert.-buty-laminomethyl-4-hydroxy-m-xylene-.alpha.1,.alpha.3-diole can be easily produced with a good yield in a continuous process, without isolating the intermediate products.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1978</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyrsKwjAUANAsDqJ-g_kArzS0ius1SU0gjxITaKZSJE6ihfr_iODudJazJFk7ka4xaDTUyqi8oK0PtAteJK7dhSKDKEPcwznFbNBq5-Ebs4EGVBbB9xks9NlIJwHZDmsQ2hu5Jov7-JjL5ueKbFsZuYIyvYYyT-OtPMt74MiqpjoeTlj_Hx9h5zB7</recordid><startdate>19781017</startdate><enddate>19781017</enddate><creator>RUOHONEN, JARKKO</creator><scope>EVB</scope></search><sort><creationdate>19781017</creationdate><title>INDUSTRIAL METHOD FOR PRODUCING A1-TERT.-BUTYLAMINO-METHYL-4-HYDROXY-M-XYLENE-A1,A3-DIOLE</title><author>RUOHONEN, JARKKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA1040658A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1978</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>RUOHONEN, JARKKO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RUOHONEN, JARKKO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INDUSTRIAL METHOD FOR PRODUCING A1-TERT.-BUTYLAMINO-METHYL-4-HYDROXY-M-XYLENE-A1,A3-DIOLE</title><date>1978-10-17</date><risdate>1978</risdate><abstract>The present invention relates to a method for producing therapeutically valuable .alpha.2-tert.-butylaminomethyl-4-hydroxy-m-xylene-.alpha.2 ,.alpha.3-diole, which has the formula and its acid addition salts, characterized in that an imine derivative having the formula where R stands for a lower straight-chain or branched hydrocarbon radical containing 1 to 6 carbon atoms, and Ar stands for an aryl group, is converted by simultaneous hydrogenation and reduction into a compound having the formula and from which the arylmethyl protective group is removed by catalytic hydration. The method, according to the invention, is appropriate for industrial production work wherein .alpha.2-tert.-buty-laminomethyl-4-hydroxy-m-xylene-.alpha.1,.alpha.3-diole can be easily produced with a good yield in a continuous process, without isolating the intermediate products.</abstract><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title INDUSTRIAL METHOD FOR PRODUCING A1-TERT.-BUTYLAMINO-METHYL-4-HYDROXY-M-XYLENE-A1,A3-DIOLE
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