compostos de 4-azetidinil-1-fenil-ciclohexano antagonistas de ccr2

The present invention comprises compounds of Formula (I): wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes,...

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Hauptverfasser: CUIFEN HOU, XUQING ZHANG, HEATHER RAE HUFNAGEL, ZHIHUA SUI, DANA L. JOHNSON
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creator CUIFEN HOU
XUQING ZHANG
HEATHER RAE HUFNAGEL
ZHIHUA SUI
DANA L. JOHNSON
description The present invention comprises compounds of Formula (I): wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title compostos de 4-azetidinil-1-fenil-ciclohexano antagonistas de ccr2
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