compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase

compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase, seu uso e sua composição farmacêutica a presente invenção refere-se a compostos heterocíclicos bicíclicos substituídos de fórmula (i) em que het1, het2, a1, a2 , a3 e a4 têm o significado definido nas reivindicações...

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Hauptverfasser:	Gregor James Macdonald, Michel Anna Jozef de Cleyn, Sven Franciscus Anna Van Brandt, Daniel Oehlrich, Henricus Jacobus Maria Gijsen, Adriana Ingrid Velter, Serge Maria Aloysius Pieters, FRANÇOIS PAUL BISCHOFF, Tongfei Wu, Mirko Zaja, Didier Jean-Claude Berthelot, Michel Surkyn
Format:	Patent
Sprache:	por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	Gregor James Macdonald Michel Anna Jozef de Cleyn Sven Franciscus Anna Van Brandt Daniel Oehlrich Henricus Jacobus Maria Gijsen Adriana Ingrid Velter Serge Maria Aloysius Pieters FRANÇOIS PAUL BISCHOFF Tongfei Wu Mirko Zaja Didier Jean-Claude Berthelot Michel Surkyn
description	compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase, seu uso e sua composição farmacêutica a presente invenção refere-se a compostos heterocíclicos bicíclicos substituídos de fórmula (i) em que het1, het2, a1, a2 , a3 e a4 têm o significado definido nas reivindicações os compostos de acordo com a presente invenção são úteis como moduladores de gama secretase. a invenção também refere-se aos processos para preparar tais novos compostos, composições farmacêuticas compreendendo os referidos compostos como um ingrediente ativo bem como o uso dos referidos compostos como um medicamento. The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190402&DB=EPODOC&CC=BR&NR=PI1008473A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190402&DB=EPODOC&CC=BR&NR=PI1008473A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Gregor James Macdonald</creatorcontrib><creatorcontrib>Michel Anna Jozef de Cleyn</creatorcontrib><creatorcontrib>Sven Franciscus Anna Van Brandt</creatorcontrib><creatorcontrib>Daniel Oehlrich</creatorcontrib><creatorcontrib>Henricus Jacobus Maria Gijsen</creatorcontrib><creatorcontrib>Adriana Ingrid Velter</creatorcontrib><creatorcontrib>Serge Maria Aloysius Pieters</creatorcontrib><creatorcontrib>FRANÇOIS PAUL BISCHOFF</creatorcontrib><creatorcontrib>Tongfei Wu</creatorcontrib><creatorcontrib>Mirko Zaja</creatorcontrib><creatorcontrib>Didier Jean-Claude Berthelot</creatorcontrib><creatorcontrib>Michel Surkyn</creatorcontrib><title>compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase</title><description>compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase, seu uso e sua composição farmacêutica a presente invenção refere-se a compostos heterocíclicos bicíclicos substituídos de fórmula (i) em que het1, het2, a1, a2 , a3 e a4 têm o significado definido nas reivindicações os compostos de acordo com a presente invenção são úteis como moduladores de gama secretase. a invenção também refere-se aos processos para preparar tais novos compostos, composições farmacêuticas compreendendo os referidos compostos como um ingrediente ativo bem como o uso dos referidos compostos como um medicamento. The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAhLzs8tyC8uyS9WyEgtSS3KTz68NjknMxnIT8pEsItLk4pLMktKD69NAfKAevIVcvNTSnMSU_KLUosVUlIV0hNzExWKU5OLUksSi1N5GFjTEnOKU3mhNDeDkptriLOHbmpBfnxqcUFicmpeakm8U1CAp6GBgYWJubGjkTFRigBuhz2G</recordid><startdate>20190402</startdate><enddate>20190402</enddate><creator>Gregor James Macdonald</creator><creator>Michel Anna Jozef de Cleyn</creator><creator>Sven Franciscus Anna Van Brandt</creator><creator>Daniel Oehlrich</creator><creator>Henricus Jacobus Maria Gijsen</creator><creator>Adriana Ingrid Velter</creator><creator>Serge Maria Aloysius Pieters</creator><creator>FRANÇOIS PAUL BISCHOFF</creator><creator>Tongfei Wu</creator><creator>Mirko Zaja</creator><creator>Didier Jean-Claude Berthelot</creator><creator>Michel Surkyn</creator><scope>EVB</scope></search><sort><creationdate>20190402</creationdate><title>compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase</title><author>Gregor James Macdonald ; Michel Anna Jozef de Cleyn ; Sven Franciscus Anna Van Brandt ; Daniel Oehlrich ; Henricus Jacobus Maria Gijsen ; Adriana Ingrid Velter ; Serge Maria Aloysius Pieters ; FRANÇOIS PAUL BISCHOFF ; Tongfei Wu ; Mirko Zaja ; Didier Jean-Claude Berthelot ; Michel Surkyn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BRPI1008473A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Gregor James Macdonald</creatorcontrib><creatorcontrib>Michel Anna Jozef de Cleyn</creatorcontrib><creatorcontrib>Sven Franciscus Anna Van Brandt</creatorcontrib><creatorcontrib>Daniel Oehlrich</creatorcontrib><creatorcontrib>Henricus Jacobus Maria Gijsen</creatorcontrib><creatorcontrib>Adriana Ingrid Velter</creatorcontrib><creatorcontrib>Serge Maria Aloysius Pieters</creatorcontrib><creatorcontrib>FRANÇOIS PAUL BISCHOFF</creatorcontrib><creatorcontrib>Tongfei Wu</creatorcontrib><creatorcontrib>Mirko Zaja</creatorcontrib><creatorcontrib>Didier Jean-Claude Berthelot</creatorcontrib><creatorcontrib>Michel Surkyn</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Gregor James Macdonald</au><au>Michel Anna Jozef de Cleyn</au><au>Sven Franciscus Anna Van Brandt</au><au>Daniel Oehlrich</au><au>Henricus Jacobus Maria Gijsen</au><au>Adriana Ingrid Velter</au><au>Serge Maria Aloysius Pieters</au><au>FRANÇOIS PAUL BISCHOFF</au><au>Tongfei Wu</au><au>Mirko Zaja</au><au>Didier Jean-Claude Berthelot</au><au>Michel Surkyn</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase</title><date>2019-04-02</date><risdate>2019</risdate><abstract>compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase, seu uso e sua composição farmacêutica a presente invenção refere-se a compostos heterocíclicos bicíclicos substituídos de fórmula (i) em que het1, het2, a1, a2 , a3 e a4 têm o significado definido nas reivindicações os compostos de acordo com a presente invenção são úteis como moduladores de gama secretase. a invenção também refere-se aos processos para preparar tais novos compostos, composições farmacêuticas compreendendo os referidos compostos como um ingrediente ativo bem como o uso dos referidos compostos como um medicamento. The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	compostos heterocíclicos bicíclicos substituídos como moduladores de gama secretase
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