agonista de receptor de glicocorticóide, composição farmacêutica, agente terapêutico para doença inflamatória, agente terapêutico para doença inflamatória ocular, agente terapêutico para distúrbio osso-junta inflamatório, método para tratar doença inflamatória, método para tratar doença inflamatória ocular, e método para tratar distúrbio oss-junta inflamatório

The object aims to find a novel pharmacological activity of a novel 1,2,3,4-tetrahydroquinoxaline derivative which contains, as a substituent, a phenyl group having a sulfonic acid ester structure introduced therein. A compound represented by general formula (1) or a salt thereof is useful as a gluc...

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Hauptverfasser: YUMI HAGIWARA, KENJI OKI, MAMORU MATSUDA, MIWA TAKAI, TOSHIYUKI MORI, TAKAHIRO MATSUYAMA, TATSUJI KUROSE, MASATOMO KATO
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creator YUMI HAGIWARA
KENJI OKI
MAMORU MATSUDA
MIWA TAKAI
TOSHIYUKI MORI
TAKAHIRO MATSUYAMA
TATSUJI KUROSE
MASATOMO KATO
description The object aims to find a novel pharmacological activity of a novel 1,2,3,4-tetrahydroquinoxaline derivative which contains, as a substituent, a phenyl group having a sulfonic acid ester structure introduced therein. A compound represented by general formula (1) or a salt thereof is useful as a glucocorticoid receptor agonist, particularly as a therapeutic agent for diseases against which a glucocorticoid receptor agonist (e.g., a steroid) is believed to be effective, such as inflammatory bone/joint diseases, inflammatory ophthalmic diseases (inflammatory ophthalmic diseases in the anterior or posterior segment of an eye). R 1 represents a group represented by general formula (2a), (3a), (4a) or (5a); R 2 represents a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, or the like; R 3 represents a lower alkyl group; R 4 , R 5 , R 6 or R 7 represent a halogen atom, a lower alkyl group which may have a substituent, a hydroxy group, a lower alkoxy group which may have a substituent, or the like; and m, n, p or q represents a number of 0, 1 or 2.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title agonista de receptor de glicocorticóide, composição farmacêutica, agente terapêutico para doença inflamatória, agente terapêutico para doença inflamatória ocular, agente terapêutico para distúrbio osso-junta inflamatório, método para tratar doença inflamatória, método para tratar doença inflamatória ocular, e método para tratar distúrbio oss-junta inflamatório
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