método para fabricar um composto

método para fabricar um composto

The invention relates to a method of manufacturing a compound according to formula (I) wherein R is C1-6alkylor C5-10aryl-C1-6alkyl, comprising the steps of: a) reacting isonicotinohydrazide and methyl isothiocyanate, thereby obtaining 2-isoni-cotinoyl-N-methylhydrazinecarbothioamide; b) under alkal...

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Hauptverfasser: Tim Stahlberg, Hans Aström, Elfyn Jones
Format: Patent
Sprache:por
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator Tim Stahlberg
Hans Aström
Elfyn Jones
description The invention relates to a method of manufacturing a compound according to formula (I) wherein R is C1-6alkylor C5-10aryl-C1-6alkyl, comprising the steps of: a) reacting isonicotinohydrazide and methyl isothiocyanate, thereby obtaining 2-isoni-cotinoyl-N-methylhydrazinecarbothioamide; b) under alkaline conditions allowing said 2-isonicotinoyl-N-methylhydrazinecar-bothioamide to undergo a ring-forming reaction, thereby obtaining 4-methyl-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione; and c) under alkaline conditions allowing said 4-methyl-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione to react with R-X, wherein R has the same meaning as in formula I and X is selected from the group of Cl, Br and I, thereby obtaining a compound according to formula I; wherein steps a), b) and c) are carried out in an aqueous environment without intermediate isolations.
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b) under alkaline conditions allowing said 2-isonicotinoyl-N-methylhydrazinecar-bothioamide to undergo a ring-forming reaction, thereby obtaining 4-methyl-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione; and c) under alkaline conditions allowing said 4-methyl-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione to react with R-X, wherein R has the same meaning as in formula I and X is selected from the group of Cl, Br and I, thereby obtaining a compound according to formula I; wherein steps a), b) and c) are carried out in an aqueous environment without intermediate isolations.</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20170606&amp;DB=EPODOC&amp;CC=BR&amp;NR=PI0923215A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20170606&amp;DB=EPODOC&amp;CC=BR&amp;NR=PI0923215A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Tim Stahlberg</creatorcontrib><creatorcontrib>Hans Aström</creatorcontrib><creatorcontrib>Elfyn Jones</creatorcontrib><title>método para fabricar um composto</title><description>The invention relates to a method of manufacturing a compound according to formula (I) wherein R is C1-6alkylor C5-10aryl-C1-6alkyl, comprising the steps of: a) reacting isonicotinohydrazide and methyl isothiocyanate, thereby obtaining 2-isoni-cotinoyl-N-methylhydrazinecarbothioamide; b) under alkaline conditions allowing said 2-isonicotinoyl-N-methylhydrazinecar-bothioamide to undergo a ring-forming reaction, thereby obtaining 4-methyl-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione; and c) under alkaline conditions allowing said 4-methyl-5-pyridin-4-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione to react with R-X, wherein R has the same meaning as in formula I and X is selected from the group of Cl, Br and I, thereby obtaining a compound according to formula I; wherein steps a), b) and c) are carried out in an aqueous environment without intermediate isolations.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDMPbyyJD8lX6EgsShRIS0xqSgzObFIoTRXITk_tyC_uCSfh4E1LTGnOJUXSnMzKLm5hjh76KYW5MenFhckJqfmpZbEOwUFeBpYGhkbGZo6GhkTpQgAJc0nFQ</recordid><startdate>20170606</startdate><enddate>20170606</enddate><creator>Tim Stahlberg</creator><creator>Hans Aström</creator><creator>Elfyn Jones</creator><scope>EVB</scope></search><sort><creationdate>20170606</creationdate><title>método para fabricar um composto</title><author>Tim Stahlberg ; Hans Aström ; Elfyn Jones</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BRPI0923215A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>Tim Stahlberg</creatorcontrib><creatorcontrib>Hans Aström</creatorcontrib><creatorcontrib>Elfyn Jones</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Tim Stahlberg</au><au>Hans Aström</au><au>Elfyn Jones</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>método para fabricar um composto</title><date>2017-06-06</date><risdate>2017</risdate><abstract>The invention relates to a method of manufacturing a compound according to formula (I) wherein R is C1-6alkylor C5-10aryl-C1-6alkyl, comprising the steps of: a) reacting isonicotinohydrazide and methyl isothiocyanate, thereby obtaining 2-isoni-cotinoyl-N-methylhydrazinecarbothioamide; 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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title método para fabricar um composto
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