antagonistas da via hedgehog de piridazina tetrassubstituída
The present invention provides novel tetrasubstituted pyridine hedgehog pathway antagonists of the following formula I (I) or a pharmaceutically acceptable salt thereof, wherein: X is C-R1 or N; R1 is hydrogen, fluoro or cyano; R2 is formula II (II), piperidinyl, or gem di-F-substituted cyclohexyl;...
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| creator | Daniel Jon Sall Julia Marie Clay Jolie Anne Bastian Michelle Lee Thompson Jeffrey Daniel Cohen Philip Arthur Hipskind Karen Lynn Lobb Takako Wilson (Nee Takakuwa) |
| description | The present invention provides novel tetrasubstituted pyridine hedgehog pathway antagonists of the following formula I (I) or a pharmaceutically acceptable salt thereof, wherein: X is C-R1 or N; R1 is hydrogen, fluoro or cyano; R2 is formula II (II), piperidinyl, or gem di-F-substituted cyclohexyl; R3 is methyl or trifluoromethyl; R4 is pyrrolidinyl, morpholinyl or pyridyl, amino or dimethylamino; R5 is trifluoromethyl or methylsulfonyl; R6 is hydrogen or methyl; and R7, R8, R9, R10 and R11 are independently hydrogen fluoro, cyano, chloro, methyl, trifluoromethyl, trifluoromethoxy or methylsulfonyl, provided that at least two of R7, R8, R9, R10 and R11 are hydrogen useful in the treatment of cancer. |
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Jeffrey Daniel Cohen ; Philip Arthur Hipskind ; Karen Lynn Lobb ; Takako Wilson (Nee Takakuwa)</creatorcontrib><description>The present invention provides novel tetrasubstituted pyridine hedgehog pathway antagonists of the following formula I (I) or a pharmaceutically acceptable salt thereof, wherein: X is C-R1 or N; R1 is hydrogen, fluoro or cyano; R2 is formula II (II), piperidinyl, or gem di-F-substituted cyclohexyl; R3 is methyl or trifluoromethyl; R4 is pyrrolidinyl, morpholinyl or pyridyl, amino or dimethylamino; R5 is trifluoromethyl or methylsulfonyl; R6 is hydrogen or methyl; and R7, R8, R9, R10 and R11 are independently hydrogen fluoro, cyano, chloro, methyl, trifluoromethyl, trifluoromethoxy or methylsulfonyl, provided that at least two of R7, R8, R9, R10 and R11 are hydrogen useful in the treatment of cancer.</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; 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Julia Marie Clay ; Jolie Anne Bastian ; Michelle Lee Thompson ; Jeffrey Daniel Cohen ; Philip Arthur Hipskind ; Karen Lynn Lobb ; Takako Wilson (Nee Takakuwa)</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BRPI0921782A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Daniel Jon Sall</creatorcontrib><creatorcontrib>Julia Marie Clay</creatorcontrib><creatorcontrib>Jolie Anne Bastian</creatorcontrib><creatorcontrib>Michelle Lee Thompson</creatorcontrib><creatorcontrib>Jeffrey Daniel Cohen</creatorcontrib><creatorcontrib>Philip Arthur Hipskind</creatorcontrib><creatorcontrib>Karen Lynn Lobb</creatorcontrib><creatorcontrib>Takako Wilson (Nee Takakuwa)</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Daniel Jon Sall</au><au>Julia Marie Clay</au><au>Jolie Anne Bastian</au><au>Michelle Lee Thompson</au><au>Jeffrey Daniel Cohen</au><au>Philip Arthur Hipskind</au><au>Karen Lynn Lobb</au><au>Takako Wilson (Nee Takakuwa)</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>antagonistas da via hedgehog de piridazina tetrassubstituída</title><date>2019-09-24</date><risdate>2019</risdate><abstract>The present invention provides novel tetrasubstituted pyridine hedgehog pathway antagonists of the following formula I (I) or a pharmaceutically acceptable salt thereof, wherein: X is C-R1 or N; 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | antagonistas da via hedgehog de piridazina tetrassubstituída |
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