Composição farmacêutica oftálmica tópica compreendendo derivados de fluoroquinolona para aplicações oftálmicas e uso da mesma

Composição farmacêutica oftálmica tópica compreendendo derivados de fluoroquinolona para aplicações oftálmicas e uso da mesma

The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections....

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Hauptverfasser: AMY C. BROOKS, GEOFFREY ROBERT OWEN, JOSEPH J. DAJCS, LINA F. BERNAL-PEREZ, DAVID W. STROMAN
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Sprache:por
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator AMY C. BROOKS
GEOFFREY ROBERT OWEN
JOSEPH J. DAJCS
LINA F. BERNAL-PEREZ
DAVID W. STROMAN
description The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections. The present invention more particularly relates to the discovery that a 2-methyl substitution on a diazabicyclo group attached to a fluoroquinolone ring system produces improved permeability characteristics, and that a 5-amino substitution on a fluoroquinolone ring system results in improved anti-microbial activity.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Composição farmacêutica oftálmica tópica compreendendo derivados de fluoroquinolona para aplicações oftálmicas e uso da mesma
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