COMPOSTOS E COMPOSIÇÕES COMO INIBIDORES DE PROTEASE DE ATIVAÇÃO DE CANAL

COMPOSTOS E COMPOSIÇÕES COMO INIBIDORES DE PROTEASE DE ATIVAÇÃO DE CANAL

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating chan-nel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prosta...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: AGNES VIDAL, BADRY BURSULAYA, ARNAB K. CHATTERJEE, DAVID C. TULLY
Format: Patent
Sprache:por
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating chan-nel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSSI1E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.