processo para preparar linezolida

PROCESSO PARA PREPARAR LINEZOLIDA. A presente invenção relaciona-se a um novo processo para preparar a oxazolidinona agente antibacteriano linezolida que compreende a reação de um (S)-1-cloro-3-(benzilidenilamino)-propan-2-ol com morfolinil fluorfenil carbamato para produzir um intermediário imina p...

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Hauptverfasser:	RICK JOSEPH IMBORDINO, MICHAEL ROBERT REEDER, WILLIAM ROLAND PERRAULT
Format:	Patent
Sprache:	por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	RICK JOSEPH IMBORDINO MICHAEL ROBERT REEDER WILLIAM ROLAND PERRAULT
description	PROCESSO PARA PREPARAR LINEZOLIDA. A presente invenção relaciona-se a um novo processo para preparar a oxazolidinona agente antibacteriano linezolida que compreende a reação de um (S)-1-cloro-3-(benzilidenilamino)-propan-2-ol com morfolinil fluorfenil carbamato para produzir um intermediário imina protegido que, sob hidrólise e acilação, produz linezolida em alta produção. The present invention relates to a new process for preparing the oxazolidinone antibacterial agent linezolid which comprises the reaction of an (S)-I -chloro-3- (benzyIidenylamino)-propan-2-ol with a morpholinyl fluorophenyl carbamate to afford a protected imine intermediate which, upon hydrolysis and acylation, yields linezolid in high yield.
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A presente invenção relaciona-se a um novo processo para preparar a oxazolidinona agente antibacteriano linezolida que compreende a reação de um (S)-1-cloro-3-(benzilidenilamino)-propan-2-ol com morfolinil fluorfenil carbamato para produzir um intermediário imina protegido que, sob hidrólise e acilação, produz linezolida em alta produção. The present invention relates to a new process for preparing the oxazolidinone antibacterial agent linezolid which comprises the reaction of an (S)-I -chloro-3- (benzyIidenylamino)-propan-2-ol with a morpholinyl fluorophenyl carbamate to afford a protected imine intermediate which, upon hydrolysis and acylation, yields linezolid in high yield.</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110809&DB=EPODOC&CC=BR&NR=PI0710312A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110809&DB=EPODOC&CC=BR&NR=PI0710312A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RICK JOSEPH IMBORDINO</creatorcontrib><creatorcontrib>MICHAEL ROBERT REEDER</creatorcontrib><creatorcontrib>WILLIAM ROLAND PERRAULT</creatorcontrib><title>processo para preparar linezolida</title><description>PROCESSO PARA PREPARAR LINEZOLIDA. A presente invenção relaciona-se a um novo processo para preparar a oxazolidinona agente antibacteriano linezolida que compreende a reação de um (S)-1-cloro-3-(benzilidenilamino)-propan-2-ol com morfolinil fluorfenil carbamato para produzir um intermediário imina protegido que, sob hidrólise e acilação, produz linezolida em alta produção. The present invention relates to a new process for preparing the oxazolidinone antibacterial agent linezolid which comprises the reaction of an (S)-I -chloro-3- (benzyIidenylamino)-propan-2-ol with a morpholinyl fluorophenyl carbamate to afford a protected imine intermediate which, upon hydrolysis and acylation, yields linezolid in high yield.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAsKMpPTi0uzlcoSCxKVCgoSgXRRQo5mXmpVfk5mSmJPAysaYk5xam8UJqbQcnNNcTZQze1ID8-tbggMTk1L7Uk3ikowNPA3NDA2NDI0ciYKEUA_pcmvA</recordid><startdate>20110809</startdate><enddate>20110809</enddate><creator>RICK JOSEPH IMBORDINO</creator><creator>MICHAEL ROBERT REEDER</creator><creator>WILLIAM ROLAND PERRAULT</creator><scope>EVB</scope></search><sort><creationdate>20110809</creationdate><title>processo para preparar linezolida</title><author>RICK JOSEPH IMBORDINO ; MICHAEL ROBERT REEDER ; WILLIAM ROLAND PERRAULT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BRPI0710312A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>RICK JOSEPH IMBORDINO</creatorcontrib><creatorcontrib>MICHAEL ROBERT REEDER</creatorcontrib><creatorcontrib>WILLIAM ROLAND PERRAULT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RICK JOSEPH IMBORDINO</au><au>MICHAEL ROBERT REEDER</au><au>WILLIAM ROLAND PERRAULT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>processo para preparar linezolida</title><date>2011-08-09</date><risdate>2011</risdate><abstract>PROCESSO PARA PREPARAR LINEZOLIDA. A presente invenção relaciona-se a um novo processo para preparar a oxazolidinona agente antibacteriano linezolida que compreende a reação de um (S)-1-cloro-3-(benzilidenilamino)-propan-2-ol com morfolinil fluorfenil carbamato para produzir um intermediário imina protegido que, sob hidrólise e acilação, produz linezolida em alta produção. The present invention relates to a new process for preparing the oxazolidinone antibacterial agent linezolid which comprises the reaction of an (S)-I -chloro-3- (benzyIidenylamino)-propan-2-ol with a morpholinyl fluorophenyl carbamate to afford a protected imine intermediate which, upon hydrolysis and acylation, yields linezolid in high yield.</abstract><oa>free_for_read</oa></addata></record>
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title	processo para preparar linezolida
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