produtos intermediários para a preparação de híbridos de oxazolidinon-quinolona

"produtos intermediários para a preparação de híbridos de oxazolidinon-quinolona". a presente invenção descreve produtos intermediários (zp) para uma síntese nova e eficiente de compostos, nos quais os farmacóforos de quinolona e oxazolidinona estão ligados uns com os outros através de um ligante quimicamente estável. Oxazolidinyl- or dihydrofuranyl-substituted fluoro-benzene or -pyridine derivatives (ZP) are new. Oxazolidinyl- or dihydrofuranyl-substituted fluoro-benzene or -pyridine derivatives of formula (ZP) are new. [Image] U : N or CH; V : O, S or CR 6>R 7>; W : (hetero)cycloalkylene, (hetero)alkylcycloalkylene, (hetero)arylene, (hetero)aralkylene (all optionally substituted), bond, O, S or NR 8>; X : O or S; Y : group of formula (a) - (f); Z : alkylene, alkenylene, alkynylene, heteroalkylene, (hetero)cycloalkylene, (hetero)alkylcycloalkylene, (hetero)arylene or (hetero)aralkylene (all optionally substituted); R 8> : hydrogen, (hetero)alkyl, alkenyl, alkynyl, (hetero)aryl, (hetero)cycloalkyl, (hetero)alkylcycloalkyl, aralkyl or heteroaralkyl; and R 6>, R 7> : hydrogen, (hetero)alkyl, alkenyl, alkynyl, (hetero)aryl, (hetero)cycloalkyl, (hetero)alkylcycloalkyl, aralkyl, heteroaralkyl, halo, hydroxy, amino, nitro or thiol. [Image] ACTIVITY : Antibacterial. No details of tests are given. MECHANISM OF ACTION : None given in the source material.