composto ativador de ppar e composição farmacêutica contendo o mesmo

"composto ativador de ppar e composição farmacêutica contendo o mesmo". é descrito um composto para ativar seletivamente ppar que é representado pela fórmula geral (1) abaixo: (em que r~ 1~ e r~ 2~ são iguais ou,diferentes e representam átomos de hidrogênio ou semelhante; r~ 3a~, r~ 3b~, r...

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Hauptverfasser:	Hidefumi Ozawa, Tsutomu Toma, Ayumu Okuda, Kazutoyo Abe, Masahiro Nishikawa, Soichi Oda, Takaaki Araki, Yukiyoshi Yamazaki
Format:	Patent
Sprache:	por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	Hidefumi Ozawa Tsutomu Toma Ayumu Okuda Kazutoyo Abe Masahiro Nishikawa Soichi Oda Takaaki Araki Yukiyoshi Yamazaki
description	"composto ativador de ppar e composição farmacêutica contendo o mesmo". é descrito um composto para ativar seletivamente ppar que é representado pela fórmula geral (1) abaixo: (em que r~ 1~ e r~ 2~ são iguais ou,diferentes e representam átomos de hidrogênio ou semelhante; r~ 3a~, r~ 3b~, r~ 4a~ e r~ 4b~ podem ser iguais ou diferentes e representam átomos de hidrogênio ou semelhantes; x representa um átomo de oxigênio ou semelhante; y representa um átomo de oxigênio, s(o)~ 1~ (1 é um número de 0 a 2), um grupo carbonila, um grupo carbonilamino, um grupo aminocarbonila, um grupo sulfonilamino, um grupo aminosulfonila, ou nh; z representa ch ou semelhante; n é um número de 1 a 6; e m é um número de 2 a 6) ou um sal seu. também é divulgada uma composição farmacêutica contendo tal composto. A compound represented by the following formula (1): (wherein each of R 1 and R 2 , which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R 3a , R 3b , R 4a , and R 4b , which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C 1-4 alkyl group, a trifluoromethyl group, a C 1-4 alkoxy group, a C 1-4 alkylcarbonyloxy group, a di-C 1-4 alkylamino group, a C 1-4 alkylsulfonyloxy group, a C 1-4 alkylsulfonyl group, a C 1-4 alkylsulfinyl group, or a C 1-4 alkylthio group, or R 3a and R 3b , or R 4a and R 4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N-R 5 (R 5 represents a hydrogen atom, a C 1-4 alkyl group, a C 1-4 alkylsulfonyl group, or a C 1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O) 1 (1 is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosulfonyl group; Z represents CH or N; n is a number of 1 to 6; and m is a number of 2 to 6) or a salt thereof; and therapeutic drugs containing any of such a compound or salt.
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A compound represented by the following formula (1): (wherein each of R 1 and R 2 , which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R 3a , R 3b , R 4a , and R 4b , which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C 1-4 alkyl group, a trifluoromethyl group, a C 1-4 alkoxy group, a C 1-4 alkylcarbonyloxy group, a di-C 1-4 alkylamino group, a C 1-4 alkylsulfonyloxy group, a C 1-4 alkylsulfonyl group, a C 1-4 alkylsulfinyl group, or a C 1-4 alkylthio group, or R 3a and R 3b , or R 4a and R 4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N-R 5 (R 5 represents a hydrogen atom, a C 1-4 alkyl group, a C 1-4 alkylsulfonyl group, or a C 1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O) 1 (1 is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosulfonyl group; Z represents CH or N; n is a number of 1 to 6; and m is a number of 2 to 6) or a salt thereof; and therapeutic drugs containing any of such a compound or salt.</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180918&DB=EPODOC&CC=BR&NR=PI0413991B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180918&DB=EPODOC&CC=BR&NR=PI0413991B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Hidefumi Ozawa</creatorcontrib><creatorcontrib>Tsutomu Toma</creatorcontrib><creatorcontrib>Ayumu Okuda</creatorcontrib><creatorcontrib>Kazutoyo Abe</creatorcontrib><creatorcontrib>Masahiro Nishikawa</creatorcontrib><creatorcontrib>Soichi Oda</creatorcontrib><creatorcontrib>Takaaki Araki</creatorcontrib><creatorcontrib>Yukiyoshi Yamazaki</creatorcontrib><title>composto ativador de ppar e composição farmacêutica contendo o mesmo</title><description>"composto ativador de ppar e composição farmacêutica contendo o mesmo". é descrito um composto para ativar seletivamente ppar que é representado pela fórmula geral (1) abaixo: (em que r~ 1~ e r~ 2~ são iguais ou,diferentes e representam átomos de hidrogênio ou semelhante; r~ 3a~, r~ 3b~, r~ 4a~ e r~ 4b~ podem ser iguais ou diferentes e representam átomos de hidrogênio ou semelhantes; x representa um átomo de oxigênio ou semelhante; y representa um átomo de oxigênio, s(o)~ 1~ (1 é um número de 0 a 2), um grupo carbonila, um grupo carbonilamino, um grupo aminocarbonila, um grupo sulfonilamino, um grupo aminosulfonila, ou nh; z representa ch ou semelhante; n é um número de 1 a 6; e m é um número de 2 a 6) ou um sal seu. também é divulgada uma composição farmacêutica contendo tal composto. A compound represented by the following formula (1): (wherein each of R 1 and R 2 , which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R 3a , R 3b , R 4a , and R 4b , which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C 1-4 alkyl group, a trifluoromethyl group, a C 1-4 alkoxy group, a C 1-4 alkylcarbonyloxy group, a di-C 1-4 alkylamino group, a C 1-4 alkylsulfonyloxy group, a C 1-4 alkylsulfonyl group, a C 1-4 alkylsulfinyl group, or a C 1-4 alkylthio group, or R 3a and R 3b , or R 4a and R 4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N-R 5 (R 5 represents a hydrogen atom, a C 1-4 alkyl group, a C 1-4 alkylsulfonyl group, or a C 1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O) 1 (1 is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosulfonyl group; Z represents CH or N; n is a number of 1 to 6; and m is a number of 2 to 6) or a salt thereof; and therapeutic drugs containing any of such a compound or salt.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBPzs8tyC8uyVdILMksS0zJL1JISVUoKEgsUkhVgMhlHl5-eHG-QlpiUW5i8uFVpSWZyYlAqbyS1LyUfIV8hdzU4tx8HgbWtMSc4lReKM3NoOTmGuLsoZtakB-fWlyQmJyal1oS7xQU4GlgYmhsaWnoZGhMlCIA40A24Q</recordid><startdate>20180918</startdate><enddate>20180918</enddate><creator>Hidefumi Ozawa</creator><creator>Tsutomu Toma</creator><creator>Ayumu Okuda</creator><creator>Kazutoyo Abe</creator><creator>Masahiro Nishikawa</creator><creator>Soichi Oda</creator><creator>Takaaki Araki</creator><creator>Yukiyoshi Yamazaki</creator><scope>EVB</scope></search><sort><creationdate>20180918</creationdate><title>composto ativador de ppar e composição farmacêutica contendo o mesmo</title><author>Hidefumi Ozawa ; Tsutomu Toma ; Ayumu Okuda ; Kazutoyo Abe ; Masahiro Nishikawa ; Soichi Oda ; Takaaki Araki ; Yukiyoshi Yamazaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BRPI0413991B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Hidefumi Ozawa</creatorcontrib><creatorcontrib>Tsutomu Toma</creatorcontrib><creatorcontrib>Ayumu Okuda</creatorcontrib><creatorcontrib>Kazutoyo Abe</creatorcontrib><creatorcontrib>Masahiro Nishikawa</creatorcontrib><creatorcontrib>Soichi Oda</creatorcontrib><creatorcontrib>Takaaki Araki</creatorcontrib><creatorcontrib>Yukiyoshi Yamazaki</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Hidefumi Ozawa</au><au>Tsutomu Toma</au><au>Ayumu Okuda</au><au>Kazutoyo Abe</au><au>Masahiro Nishikawa</au><au>Soichi Oda</au><au>Takaaki Araki</au><au>Yukiyoshi Yamazaki</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>composto ativador de ppar e composição farmacêutica contendo o mesmo</title><date>2018-09-18</date><risdate>2018</risdate><abstract>"composto ativador de ppar e composição farmacêutica contendo o mesmo". é descrito um composto para ativar seletivamente ppar que é representado pela fórmula geral (1) abaixo: (em que r~ 1~ e r~ 2~ são iguais ou,diferentes e representam átomos de hidrogênio ou semelhante; r~ 3a~, r~ 3b~, r~ 4a~ e r~ 4b~ podem ser iguais ou diferentes e representam átomos de hidrogênio ou semelhantes; x representa um átomo de oxigênio ou semelhante; y representa um átomo de oxigênio, s(o)~ 1~ (1 é um número de 0 a 2), um grupo carbonila, um grupo carbonilamino, um grupo aminocarbonila, um grupo sulfonilamino, um grupo aminosulfonila, ou nh; z representa ch ou semelhante; n é um número de 1 a 6; e m é um número de 2 a 6) ou um sal seu. também é divulgada uma composição farmacêutica contendo tal composto. A compound represented by the following formula (1): (wherein each of R 1 and R 2 , which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R 3a , R 3b , R 4a , and R 4b , which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C 1-4 alkyl group, a trifluoromethyl group, a C 1-4 alkoxy group, a C 1-4 alkylcarbonyloxy group, a di-C 1-4 alkylamino group, a C 1-4 alkylsulfonyloxy group, a C 1-4 alkylsulfonyl group, a C 1-4 alkylsulfinyl group, or a C 1-4 alkylthio group, or R 3a and R 3b , or R 4a and R 4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N-R 5 (R 5 represents a hydrogen atom, a C 1-4 alkyl group, a C 1-4 alkylsulfonyl group, or a C 1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O) 1 (1 is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosulfonyl group; Z represents CH or N; n is a number of 1 to 6; and m is a number of 2 to 6) or a salt thereof; and therapeutic drugs containing any of such a compound or salt.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	composto ativador de ppar e composição farmacêutica contendo o mesmo
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