processo para preparar o agente antiviral [1s-(1alfa, 3alfa, 4beta)]-2-amino-1,9-diidro-9-[4-hidróxi-3-(hidroximetil)-2-metilenociclopentil]-6h-purin-6-ona método de seu isolamento, preparação do éster e respectivos compostos
"processo para preparar o agente antiviral [1s-(1alfa, 3alfa, 4beta)]-2-amino-1,9-diidro-9-[4-hidróxi3-(hidroximetil)-2-metilenociclopentil]-6h-purin-6-ona". a presente invenção refere-se a processos para preparar o agente antiviral entecavir. também é revelado um processo de adsorção de r...
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| creator | David R. Kronenthal Shaopeng Wang Yadagiri Pendri Sunil S. Patel Milan Stojanovic Ambarish K. Singh Siva Josyula Prasad Purushotham Vemishetti David J. Kucera Charles Lewis Dhileepkumar Krishnamurty Jeffrey T. Bien Richard Polniaszek Amit Banerjee John Thottathil Jing Liang Maotang X. Zhou Jeffrey M. Evans Zhongping Shi Yeung Y. Chan GERALD L. POWERS Sushil K. Rijhwani Ramesh N. Patel Chung-Pin Chen |
| description | "processo para preparar o agente antiviral [1s-(1alfa, 3alfa, 4beta)]-2-amino-1,9-diidro-9-[4-hidróxi3-(hidroximetil)-2-metilenociclopentil]-6h-purin-6-ona". a presente invenção refere-se a processos para preparar o agente antiviral entecavir. também é revelado um processo de adsorção de resina para o isolamento e a purificação de entecavir. também são revelados vários intermediários úteis na preparação de entecavir.
The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising:
(a) adsorbing the diluted mixture onto a hydrophobic resin bed;
(b) washing the resin bed with water to remove salt; and
(c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent. |
| format | Patent |
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The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising:
(a) adsorbing the diluted mixture onto a hydrophobic resin bed;
(b) washing the resin bed with water to remove salt; and
(c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.</description><language>por</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191224&DB=EPODOC&CC=BR&NR=PI0317255B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191224&DB=EPODOC&CC=BR&NR=PI0317255B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>David R. Kronenthal</creatorcontrib><creatorcontrib>Shaopeng Wang</creatorcontrib><creatorcontrib>Yadagiri Pendri</creatorcontrib><creatorcontrib>Sunil S. Patel</creatorcontrib><creatorcontrib>Milan Stojanovic</creatorcontrib><creatorcontrib>Ambarish K. Singh</creatorcontrib><creatorcontrib>Siva Josyula Prasad</creatorcontrib><creatorcontrib>Purushotham Vemishetti</creatorcontrib><creatorcontrib>David J. Kucera</creatorcontrib><creatorcontrib>Charles Lewis</creatorcontrib><creatorcontrib>Dhileepkumar Krishnamurty</creatorcontrib><creatorcontrib>Jeffrey T. Bien</creatorcontrib><creatorcontrib>Richard Polniaszek</creatorcontrib><creatorcontrib>Amit Banerjee</creatorcontrib><creatorcontrib>John Thottathil</creatorcontrib><creatorcontrib>Jing Liang</creatorcontrib><creatorcontrib>Maotang X. Zhou</creatorcontrib><creatorcontrib>Jeffrey M. Evans</creatorcontrib><creatorcontrib>Zhongping Shi</creatorcontrib><creatorcontrib>Yeung Y. Chan</creatorcontrib><creatorcontrib>GERALD L. POWERS</creatorcontrib><creatorcontrib>Sushil K. Rijhwani</creatorcontrib><creatorcontrib>Ramesh N. Patel</creatorcontrib><creatorcontrib>Chung-Pin Chen</creatorcontrib><title>processo para preparar o agente antiviral [1s-(1alfa, 3alfa, 4beta)]-2-amino-1,9-diidro-9-[4-hidróxi-3-(hidroximetil)-2-metilenociclopentil]-6h-purin-6-ona método de seu isolamento, preparação do éster e respectivos compostos</title><description>"processo para preparar o agente antiviral [1s-(1alfa, 3alfa, 4beta)]-2-amino-1,9-diidro-9-[4-hidróxi3-(hidroximetil)-2-metilenociclopentil]-6h-purin-6-ona". a presente invenção refere-se a processos para preparar o agente antiviral entecavir. também é revelado um processo de adsorção de resina para o isolamento e a purificação de entecavir. também são revelados vários intermediários úteis na preparação de entecavir.
The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising:
(a) adsorbing the diluted mixture onto a hydrophobic resin bed;
(b) washing the resin bed with water to remove salt; and
(c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjkFKA0EQRWfjQtQ7FK4SmAInk0SyjSi6E3EXQih7Kqagp6vp7kju40Ky9gh9F89hR-Pe1XtQ_1P_tPryQQ3HqOApEPjABwZQoFd2iYFckjcJZGHRRBw0ZNdUQ_uL8QsnGi5xhNSLU2zqGXYiXVCc4WKMm6L5cyfY4uDgupOek9hhafwIOzVirPryS-wSpxv02yAOp6iOoM_7pJ1CxxB5CxLVUl-iWv8tzR_5vdwV8j4mDsAQOHo2ZbRGMNp7jUnjeXWyJhv54siz6vLu9vnmHtnrqhTIsOO0mj89Ply1zfVoMpk37b9C36Shb9E</recordid><startdate>20191224</startdate><enddate>20191224</enddate><creator>David R. Kronenthal</creator><creator>Shaopeng Wang</creator><creator>Yadagiri Pendri</creator><creator>Sunil S. Patel</creator><creator>Milan Stojanovic</creator><creator>Ambarish K. Singh</creator><creator>Siva Josyula Prasad</creator><creator>Purushotham Vemishetti</creator><creator>David J. Kucera</creator><creator>Charles Lewis</creator><creator>Dhileepkumar Krishnamurty</creator><creator>Jeffrey T. Bien</creator><creator>Richard Polniaszek</creator><creator>Amit Banerjee</creator><creator>John Thottathil</creator><creator>Jing Liang</creator><creator>Maotang X. Zhou</creator><creator>Jeffrey M. Evans</creator><creator>Zhongping Shi</creator><creator>Yeung Y. Chan</creator><creator>GERALD L. POWERS</creator><creator>Sushil K. Rijhwani</creator><creator>Ramesh N. Patel</creator><creator>Chung-Pin Chen</creator><scope>EVB</scope></search><sort><creationdate>20191224</creationdate><title>processo para preparar o agente antiviral [1s-(1alfa, 3alfa, 4beta)]-2-amino-1,9-diidro-9-[4-hidróxi-3-(hidroximetil)-2-metilenociclopentil]-6h-purin-6-ona método de seu isolamento, preparação do éster e respectivos compostos</title><author>David R. Kronenthal ; Shaopeng Wang ; Yadagiri Pendri ; Sunil S. Patel ; Milan Stojanovic ; Ambarish K. Singh ; Siva Josyula Prasad ; Purushotham Vemishetti ; David J. Kucera ; Charles Lewis ; Dhileepkumar Krishnamurty ; Jeffrey T. Bien ; Richard Polniaszek ; Amit Banerjee ; John Thottathil ; Jing Liang ; Maotang X. Zhou ; Jeffrey M. Evans ; Zhongping Shi ; Yeung Y. Chan ; GERALD L. POWERS ; Sushil K. Rijhwani ; Ramesh N. Patel ; Chung-Pin Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BRPI0317255B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2019</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>David R. Kronenthal</creatorcontrib><creatorcontrib>Shaopeng Wang</creatorcontrib><creatorcontrib>Yadagiri Pendri</creatorcontrib><creatorcontrib>Sunil S. Patel</creatorcontrib><creatorcontrib>Milan Stojanovic</creatorcontrib><creatorcontrib>Ambarish K. Singh</creatorcontrib><creatorcontrib>Siva Josyula Prasad</creatorcontrib><creatorcontrib>Purushotham Vemishetti</creatorcontrib><creatorcontrib>David J. Kucera</creatorcontrib><creatorcontrib>Charles Lewis</creatorcontrib><creatorcontrib>Dhileepkumar Krishnamurty</creatorcontrib><creatorcontrib>Jeffrey T. Bien</creatorcontrib><creatorcontrib>Richard Polniaszek</creatorcontrib><creatorcontrib>Amit Banerjee</creatorcontrib><creatorcontrib>John Thottathil</creatorcontrib><creatorcontrib>Jing Liang</creatorcontrib><creatorcontrib>Maotang X. Zhou</creatorcontrib><creatorcontrib>Jeffrey M. Evans</creatorcontrib><creatorcontrib>Zhongping Shi</creatorcontrib><creatorcontrib>Yeung Y. Chan</creatorcontrib><creatorcontrib>GERALD L. POWERS</creatorcontrib><creatorcontrib>Sushil K. Rijhwani</creatorcontrib><creatorcontrib>Ramesh N. Patel</creatorcontrib><creatorcontrib>Chung-Pin Chen</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>David R. Kronenthal</au><au>Shaopeng Wang</au><au>Yadagiri Pendri</au><au>Sunil S. Patel</au><au>Milan Stojanovic</au><au>Ambarish K. Singh</au><au>Siva Josyula Prasad</au><au>Purushotham Vemishetti</au><au>David J. Kucera</au><au>Charles Lewis</au><au>Dhileepkumar Krishnamurty</au><au>Jeffrey T. Bien</au><au>Richard Polniaszek</au><au>Amit Banerjee</au><au>John Thottathil</au><au>Jing Liang</au><au>Maotang X. Zhou</au><au>Jeffrey M. Evans</au><au>Zhongping Shi</au><au>Yeung Y. Chan</au><au>GERALD L. POWERS</au><au>Sushil K. Rijhwani</au><au>Ramesh N. Patel</au><au>Chung-Pin Chen</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>processo para preparar o agente antiviral [1s-(1alfa, 3alfa, 4beta)]-2-amino-1,9-diidro-9-[4-hidróxi-3-(hidroximetil)-2-metilenociclopentil]-6h-purin-6-ona método de seu isolamento, preparação do éster e respectivos compostos</title><date>2019-12-24</date><risdate>2019</risdate><abstract>"processo para preparar o agente antiviral [1s-(1alfa, 3alfa, 4beta)]-2-amino-1,9-diidro-9-[4-hidróxi3-(hidroximetil)-2-metilenociclopentil]-6h-purin-6-ona". a presente invenção refere-se a processos para preparar o agente antiviral entecavir. também é revelado um processo de adsorção de resina para o isolamento e a purificação de entecavir. também são revelados vários intermediários úteis na preparação de entecavir.
The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising:
(a) adsorbing the diluted mixture onto a hydrophobic resin bed;
(b) washing the resin bed with water to remove salt; and
(c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | processo para preparar o agente antiviral [1s-(1alfa, 3alfa, 4beta)]-2-amino-1,9-diidro-9-[4-hidróxi-3-(hidroximetil)-2-metilenociclopentil]-6h-purin-6-ona método de seu isolamento, preparação do éster e respectivos compostos |
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