compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos
compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos. a presente invenção se refere a compostos de formula geral (i) os quais são inibidores de nucleosídeo fosforilase de purina (pnp), fosforibosiltransferase de purina (pprt), fosforilase de 5'-metiltioa...
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| creator | Dirk Henning Lenz Olga Vladmirovna Zubkova Peter Charles Tyler Richard Hubert Furneaux Vern L. Schramm Gary Brian Evans |
| description | compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos. a presente invenção se refere a compostos de formula geral (i) os quais são inibidores de nucleosídeo fosforilase de purina (pnp), fosforibosiltransferase de purina (pprt), fosforilase de 5'-metiltioadenosina (mtap), nucleosidade de 5'-metiltioadenosina (mtan) e/ou hidrolase de nucleosídeo (nh) . a invenção também se refere ao uso destes compostos no tratamento de doenças e infecções incluindo câncer, infecções bacterianas, infecções por protozoários e doença mediada da célula-t e composições farmacêuticas contendo estes compostos.
The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds. |
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The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.</description><language>por</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210525&DB=EPODOC&CC=BR&NR=PI0313664B8$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210525&DB=EPODOC&CC=BR&NR=PI0313664B8$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Dirk Henning Lenz</creatorcontrib><creatorcontrib>Olga Vladmirovna Zubkova</creatorcontrib><creatorcontrib>Peter Charles Tyler</creatorcontrib><creatorcontrib>Richard Hubert Furneaux</creatorcontrib><creatorcontrib>Vern L. Schramm</creatorcontrib><creatorcontrib>Gary Brian Evans</creatorcontrib><title>compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos</title><description>compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos. a presente invenção se refere a compostos de formula geral (i) os quais são inibidores de nucleosídeo fosforilase de purina (pnp), fosforibosiltransferase de purina (pprt), fosforilase de 5'-metiltioadenosina (mtap), nucleosidade de 5'-metiltioadenosina (mtan) e/ou hidrolase de nucleosídeo (nh) . a invenção também se refere ao uso destes compostos no tratamento de doenças e infecções incluindo câncer, infecções bacterianas, infecções por protozoários e doença mediada da célula-t e composições farmacêuticas contendo estes compostos.
The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEKwkAURLexEPUOH2sFJRJSRxTtROzjmv0LH9b8JZM9k5WlJ8jFDCjWVsPw5s3YXGu9R0WnIGnkJk5bBjmmJtWBFf3TsZJXeG0lWDD9kLihYkFIFvS5kf7RvwafCZxACYqpGXkbwLNvTsx8v7tsD0uOWjGirbnhrirPp-MqW2d5vimL7K_RG8QtQPk</recordid><startdate>20210525</startdate><enddate>20210525</enddate><creator>Dirk Henning Lenz</creator><creator>Olga Vladmirovna Zubkova</creator><creator>Peter Charles Tyler</creator><creator>Richard Hubert Furneaux</creator><creator>Vern L. Schramm</creator><creator>Gary Brian Evans</creator><scope>EVB</scope></search><sort><creationdate>20210525</creationdate><title>compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos</title><author>Dirk Henning Lenz ; Olga Vladmirovna Zubkova ; Peter Charles Tyler ; Richard Hubert Furneaux ; Vern L. Schramm ; Gary Brian Evans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BRPI0313664B83</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>Dirk Henning Lenz</creatorcontrib><creatorcontrib>Olga Vladmirovna Zubkova</creatorcontrib><creatorcontrib>Peter Charles Tyler</creatorcontrib><creatorcontrib>Richard Hubert Furneaux</creatorcontrib><creatorcontrib>Vern L. Schramm</creatorcontrib><creatorcontrib>Gary Brian Evans</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Dirk Henning Lenz</au><au>Olga Vladmirovna Zubkova</au><au>Peter Charles Tyler</au><au>Richard Hubert Furneaux</au><au>Vern L. Schramm</au><au>Gary Brian Evans</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos</title><date>2021-05-25</date><risdate>2021</risdate><abstract>compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos. a presente invenção se refere a compostos de formula geral (i) os quais são inibidores de nucleosídeo fosforilase de purina (pnp), fosforibosiltransferase de purina (pprt), fosforilase de 5'-metiltioadenosina (mtap), nucleosidade de 5'-metiltioadenosina (mtan) e/ou hidrolase de nucleosídeo (nh) . a invenção também se refere ao uso destes compostos no tratamento de doenças e infecções incluindo câncer, infecções bacterianas, infecções por protozoários e doença mediada da célula-t e composições farmacêuticas contendo estes compostos.
The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos |
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