peptídeos com capacidade de ligação com o sítio de fosforilação por caseína quinase ii, e, composição farmacêutica
"peptídeos com capacidade de ligação com o sítio de fosforilação por caseína quinase ii, composição farmacêutica, uso dos peptídeos, e, vetor de expressão em células de mamíferos". peptídeos úteis para o tratamento de tumores de origem epitelial e especialmente aqueles associados a tipos o...
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| creator | Luis Javier González López Silvio Ernesto Perea Rodríguez Yaquelín Puchades Izaguirre Osvaldo Reyes Acosta Belkis González Barrios Ricardo Silva Rodríguez Alejandro Moro Soria Alicia Santos Savio Nelson Francisco Santiago Vispo |
| description | "peptídeos com capacidade de ligação com o sítio de fosforilação por caseína quinase ii, composição farmacêutica, uso dos peptídeos, e, vetor de expressão em células de mamíferos". peptídeos úteis para o tratamento de tumores de origem epitelial e especialmente aqueles associados a tipos oncogênicos de vírus papiloma (hpv). identificação de peptídeos cuja estrutura permita o bloqueio do domínio de fosforilação por caseína quinase (ckii) mediante a interação direta com referido sítio. na presente invenção mostra-se onze peptídeos com estrutura cíclica e seqüência de aminoácidos diferente, os quais inibem o sítio de fosforilação por ckii in vitro, produzem citotoxicidade em células de carcinoma de colo uterino humano transformadas por hpv-16 (caski) e, adicionalmente, incrementam a sensibilidade de referidas células ao efeito citostático do interferon (ifn). a invenção refere-se adicionalmente ao uso de moléculas miméticas tanto de origem peptídica como de origem química.
11 specific peptides (A), also their homologous variants and mimetics produced by synthetic or recombinant methods, that bind to the phosphorylation site of casein kinase II, are new. 11 specific peptides (A), of formulae (1)-(11) also their homologous variants and mimetics produced by synthetic or recombinant methods, that bind to the phosphorylation site of casein kinase II, are new. (1) Cys-Ser-Val-Arg-Gln-Gly-Pro-Val-Gln-Lys-Cys; (2) Cys-Ser-Ser-Cys-Gln-Asn-Ser-Pro-Ala-Leu-Cys; (3) Cys-Gln-Ile-Pro-Gln-Arg-Thr-Ala-Thr-Arg-Cys; (4) Cys-Ala-Lys-Gln-Arg-Thr-Asp-Pro-Gly-Tyr-Cys; (5) Cys-Trp-Met-Ser-Pro-Arg-His-Leu-Gly-Thr-Cys; (6) Cys-Arg-Asn-Cys-Thr-Val-Ile-Gln-Phe-Ser-Cys; (7) Cys-His-Tyr-Ile-Ala-Gly-Thr-Val-Gln-Gly-Cys; (8) Cys-Pro-Leu-Val-Ser-Leu-Arg-Asp-His-Ser-Cys; (9) Cys-Lys-Gln-Ser-Tyr-Leu-His-His-Leu-Leu-Cys; (10) Cys-Phe-Gln-Pro-Leu-Thr-Pro-Leu-Cys-Arg-Cys; and (11) Cys-Gln-Ser-Tyr-His-Glu-Leu-Leu-Leu-Gln-Cys. An independent claim is also included for an expression vector, functional in mammalian cells, that contains a DNA sequence encoding (A). ACTIVITY : Cytostatic. H-125 non-small cell lung carcinoma cells were implanted in mice together with 10 mg/kg of peptide (1) Cys-Ser-Val-Arg-Gln-Gly-Pro-Val-Gln-Lys-Cys and the same dose of peptide administered every other day. After 30 days, the tumor volume was about 0.6 mm 3> compared with 1.5 mm 3> for untreated controls. MECHANISM OF ACTION : (A) inhibit casein kinase II and also bind to the phosphorylation site at positions 28-38 in |
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11 specific peptides (A), also their homologous variants and mimetics produced by synthetic or recombinant methods, that bind to the phosphorylation site of casein kinase II, are new. 11 specific peptides (A), of formulae (1)-(11) also their homologous variants and mimetics produced by synthetic or recombinant methods, that bind to the phosphorylation site of casein kinase II, are new. (1) Cys-Ser-Val-Arg-Gln-Gly-Pro-Val-Gln-Lys-Cys; (2) Cys-Ser-Ser-Cys-Gln-Asn-Ser-Pro-Ala-Leu-Cys; (3) Cys-Gln-Ile-Pro-Gln-Arg-Thr-Ala-Thr-Arg-Cys; (4) Cys-Ala-Lys-Gln-Arg-Thr-Asp-Pro-Gly-Tyr-Cys; (5) Cys-Trp-Met-Ser-Pro-Arg-His-Leu-Gly-Thr-Cys; (6) Cys-Arg-Asn-Cys-Thr-Val-Ile-Gln-Phe-Ser-Cys; (7) Cys-His-Tyr-Ile-Ala-Gly-Thr-Val-Gln-Gly-Cys; (8) Cys-Pro-Leu-Val-Ser-Leu-Arg-Asp-His-Ser-Cys; (9) Cys-Lys-Gln-Ser-Tyr-Leu-His-His-Leu-Leu-Cys; (10) Cys-Phe-Gln-Pro-Leu-Thr-Pro-Leu-Cys-Arg-Cys; and (11) Cys-Gln-Ser-Tyr-His-Glu-Leu-Leu-Leu-Gln-Cys. An independent claim is also included for an expression vector, functional in mammalian cells, that contains a DNA sequence encoding (A). ACTIVITY : Cytostatic. H-125 non-small cell lung carcinoma cells were implanted in mice together with 10 mg/kg of peptide (1) Cys-Ser-Val-Arg-Gln-Gly-Pro-Val-Gln-Lys-Cys and the same dose of peptide administered every other day. After 30 days, the tumor volume was about 0.6 mm 3> compared with 1.5 mm 3> for untreated controls. MECHANISM OF ACTION : (A) inhibit casein kinase II and also bind to the phosphorylation site at positions 28-38 in the E7 oncoprotein of HPV, so are toxic to cervical carcinoma cells and also increase the sensitivity of such cells to interferon; Gene therapy.</description><language>por</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210525&DB=EPODOC&CC=BR&NR=PI0215213C1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210525&DB=EPODOC&CC=BR&NR=PI0215213C1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Luis Javier González López</creatorcontrib><creatorcontrib>Silvio Ernesto Perea Rodríguez</creatorcontrib><creatorcontrib>Yaquelín Puchades Izaguirre</creatorcontrib><creatorcontrib>Osvaldo Reyes Acosta</creatorcontrib><creatorcontrib>Belkis González Barrios</creatorcontrib><creatorcontrib>Ricardo Silva Rodríguez</creatorcontrib><creatorcontrib>Alejandro Moro Soria</creatorcontrib><creatorcontrib>Alicia Santos Savio</creatorcontrib><creatorcontrib>Nelson Francisco Santiago Vispo</creatorcontrib><title>peptídeos com capacidade de ligação com o sítio de fosforilação por caseína quinase ii, e, composição farmacêutica</title><description>"peptídeos com capacidade de ligação com o sítio de fosforilação por caseína quinase ii, composição farmacêutica, uso dos peptídeos, e, vetor de expressão em células de mamíferos". peptídeos úteis para o tratamento de tumores de origem epitelial e especialmente aqueles associados a tipos oncogênicos de vírus papiloma (hpv). identificação de peptídeos cuja estrutura permita o bloqueio do domínio de fosforilação por caseína quinase (ckii) mediante a interação direta com referido sítio. na presente invenção mostra-se onze peptídeos com estrutura cíclica e seqüência de aminoácidos diferente, os quais inibem o sítio de fosforilação por ckii in vitro, produzem citotoxicidade em células de carcinoma de colo uterino humano transformadas por hpv-16 (caski) e, adicionalmente, incrementam a sensibilidade de referidas células ao efeito citostático do interferon (ifn). a invenção refere-se adicionalmente ao uso de moléculas miméticas tanto de origem peptídica como de origem química.
11 specific peptides (A), also their homologous variants and mimetics produced by synthetic or recombinant methods, that bind to the phosphorylation site of casein kinase II, are new. 11 specific peptides (A), of formulae (1)-(11) also their homologous variants and mimetics produced by synthetic or recombinant methods, that bind to the phosphorylation site of casein kinase II, are new. (1) Cys-Ser-Val-Arg-Gln-Gly-Pro-Val-Gln-Lys-Cys; (2) Cys-Ser-Ser-Cys-Gln-Asn-Ser-Pro-Ala-Leu-Cys; (3) Cys-Gln-Ile-Pro-Gln-Arg-Thr-Ala-Thr-Arg-Cys; (4) Cys-Ala-Lys-Gln-Arg-Thr-Asp-Pro-Gly-Tyr-Cys; (5) Cys-Trp-Met-Ser-Pro-Arg-His-Leu-Gly-Thr-Cys; (6) Cys-Arg-Asn-Cys-Thr-Val-Ile-Gln-Phe-Ser-Cys; (7) Cys-His-Tyr-Ile-Ala-Gly-Thr-Val-Gln-Gly-Cys; (8) Cys-Pro-Leu-Val-Ser-Leu-Arg-Asp-His-Ser-Cys; (9) Cys-Lys-Gln-Ser-Tyr-Leu-His-His-Leu-Leu-Cys; (10) Cys-Phe-Gln-Pro-Leu-Thr-Pro-Leu-Cys-Arg-Cys; and (11) Cys-Gln-Ser-Tyr-His-Glu-Leu-Leu-Leu-Gln-Cys. An independent claim is also included for an expression vector, functional in mammalian cells, that contains a DNA sequence encoding (A). ACTIVITY : Cytostatic. H-125 non-small cell lung carcinoma cells were implanted in mice together with 10 mg/kg of peptide (1) Cys-Ser-Val-Arg-Gln-Gly-Pro-Val-Gln-Lys-Cys and the same dose of peptide administered every other day. After 30 days, the tumor volume was about 0.6 mm 3> compared with 1.5 mm 3> for untreated controls. MECHANISM OF ACTION : (A) inhibit casein kinase II and also bind to the phosphorylation site at positions 28-38 in the E7 oncoprotein of HPV, so are toxic to cervical carcinoma cells and also increase the sensitivity of such cells to interferon; Gene therapy.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjjEKwkAURNNYiHqHxTqCSfACCYp2Ivbhs_krH5L8NX_TeRsLQcgp9mJuNAcQBmbgzcDMo4dF6_xQIYvS3CgNFjRVUKEKqukG_uWf_GWsxA-OeCSGxXBH9YQtd2Eq6IcW1L2nNmRFFCuMx6lloV_RQNeA9u_ekYZlNDNQC64mX0Trw_5aHDdouUQJT7BFV-aX82mbJrs0yYok-6v0AeAMTkc</recordid><startdate>20210525</startdate><enddate>20210525</enddate><creator>Luis Javier González López</creator><creator>Silvio Ernesto Perea Rodríguez</creator><creator>Yaquelín Puchades Izaguirre</creator><creator>Osvaldo Reyes Acosta</creator><creator>Belkis González Barrios</creator><creator>Ricardo Silva Rodríguez</creator><creator>Alejandro Moro Soria</creator><creator>Alicia Santos Savio</creator><creator>Nelson Francisco Santiago Vispo</creator><scope>EVB</scope></search><sort><creationdate>20210525</creationdate><title>peptídeos com capacidade de ligação com o sítio de fosforilação por caseína quinase ii, e, composição farmacêutica</title><author>Luis Javier González López ; Silvio Ernesto Perea Rodríguez ; Yaquelín Puchades Izaguirre ; Osvaldo Reyes Acosta ; Belkis González Barrios ; Ricardo Silva Rodríguez ; Alejandro Moro Soria ; Alicia Santos Savio ; Nelson Francisco Santiago Vispo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BRPI0215213C13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2021</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>Luis Javier González López</creatorcontrib><creatorcontrib>Silvio Ernesto Perea Rodríguez</creatorcontrib><creatorcontrib>Yaquelín Puchades Izaguirre</creatorcontrib><creatorcontrib>Osvaldo Reyes Acosta</creatorcontrib><creatorcontrib>Belkis González Barrios</creatorcontrib><creatorcontrib>Ricardo Silva Rodríguez</creatorcontrib><creatorcontrib>Alejandro Moro Soria</creatorcontrib><creatorcontrib>Alicia Santos Savio</creatorcontrib><creatorcontrib>Nelson Francisco Santiago Vispo</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Luis Javier González López</au><au>Silvio Ernesto Perea Rodríguez</au><au>Yaquelín Puchades Izaguirre</au><au>Osvaldo Reyes Acosta</au><au>Belkis González Barrios</au><au>Ricardo Silva Rodríguez</au><au>Alejandro Moro Soria</au><au>Alicia Santos Savio</au><au>Nelson Francisco Santiago Vispo</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>peptídeos com capacidade de ligação com o sítio de fosforilação por caseína quinase ii, e, composição farmacêutica</title><date>2021-05-25</date><risdate>2021</risdate><abstract>"peptídeos com capacidade de ligação com o sítio de fosforilação por caseína quinase ii, composição farmacêutica, uso dos peptídeos, e, vetor de expressão em células de mamíferos". peptídeos úteis para o tratamento de tumores de origem epitelial e especialmente aqueles associados a tipos oncogênicos de vírus papiloma (hpv). identificação de peptídeos cuja estrutura permita o bloqueio do domínio de fosforilação por caseína quinase (ckii) mediante a interação direta com referido sítio. na presente invenção mostra-se onze peptídeos com estrutura cíclica e seqüência de aminoácidos diferente, os quais inibem o sítio de fosforilação por ckii in vitro, produzem citotoxicidade em células de carcinoma de colo uterino humano transformadas por hpv-16 (caski) e, adicionalmente, incrementam a sensibilidade de referidas células ao efeito citostático do interferon (ifn). a invenção refere-se adicionalmente ao uso de moléculas miméticas tanto de origem peptídica como de origem química.
11 specific peptides (A), also their homologous variants and mimetics produced by synthetic or recombinant methods, that bind to the phosphorylation site of casein kinase II, are new. 11 specific peptides (A), of formulae (1)-(11) also their homologous variants and mimetics produced by synthetic or recombinant methods, that bind to the phosphorylation site of casein kinase II, are new. (1) Cys-Ser-Val-Arg-Gln-Gly-Pro-Val-Gln-Lys-Cys; (2) Cys-Ser-Ser-Cys-Gln-Asn-Ser-Pro-Ala-Leu-Cys; (3) Cys-Gln-Ile-Pro-Gln-Arg-Thr-Ala-Thr-Arg-Cys; (4) Cys-Ala-Lys-Gln-Arg-Thr-Asp-Pro-Gly-Tyr-Cys; (5) Cys-Trp-Met-Ser-Pro-Arg-His-Leu-Gly-Thr-Cys; (6) Cys-Arg-Asn-Cys-Thr-Val-Ile-Gln-Phe-Ser-Cys; (7) Cys-His-Tyr-Ile-Ala-Gly-Thr-Val-Gln-Gly-Cys; (8) Cys-Pro-Leu-Val-Ser-Leu-Arg-Asp-His-Ser-Cys; (9) Cys-Lys-Gln-Ser-Tyr-Leu-His-His-Leu-Leu-Cys; (10) Cys-Phe-Gln-Pro-Leu-Thr-Pro-Leu-Cys-Arg-Cys; and (11) Cys-Gln-Ser-Tyr-His-Glu-Leu-Leu-Leu-Gln-Cys. An independent claim is also included for an expression vector, functional in mammalian cells, that contains a DNA sequence encoding (A). ACTIVITY : Cytostatic. H-125 non-small cell lung carcinoma cells were implanted in mice together with 10 mg/kg of peptide (1) Cys-Ser-Val-Arg-Gln-Gly-Pro-Val-Gln-Lys-Cys and the same dose of peptide administered every other day. After 30 days, the tumor volume was about 0.6 mm 3> compared with 1.5 mm 3> for untreated controls. MECHANISM OF ACTION : (A) inhibit casein kinase II and also bind to the phosphorylation site at positions 28-38 in the E7 oncoprotein of HPV, so are toxic to cervical carcinoma cells and also increase the sensitivity of such cells to interferon; Gene therapy.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | peptídeos com capacidade de ligação com o sítio de fosforilação por caseína quinase ii, e, composição farmacêutica |
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