formulação farmacêutica de microcápsula de liberação controlada

formulação farmacêutica de microcápsula de liberação controlada

Novel burst-free, sustained release biocompatible and biodegradable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologicall...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: F. DONALD ROBERTS, ROBERT H. REID, CHARLES E. MCQUEEN, JOHN F. VAN HAMONT, RAMASUBBU JEYANTHI, JEAN A. SETTERSTROM, PHIL FRIDEN
Format: Patent
Sprache:por
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Novel burst-free, sustained release biocompatible and biodegradable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.