Composto, composição farmacêutica e processo para a preparação do dito composto

This invention relates to intermediates useful in the production of substituted pyridopyrimidinones of general formula (I): wherein n is 0 to 3; R and R are, independently, H, C1-C6alkyl, hydroxy(C1-C6alkyl), formyl, carbonyl(C1-C6alkyl), carboxy, or carboxy(C1-C6alkyl); R and R are, independently, H, C1-C6alkyl, or hydroxy; R and R are H, or one of -CR R and -CR R is a carbonyl group; with the proviso that at least one of the groups R and R must be hydroxy(C1-C6alkyl), formyl, carbonyl(C1-C6alkyl), carboxy, or carboxy(C1-C6alkyl); or one of R and R must be hydroxy; or one of -CR R and -CR R must be a carbonyl group; ; Ar is wherein W is H, C1-C6alkyl, halogen, hydroxy, or C1-C6alkoxy; Ar is wherein X is wherein R is H, CH3, tert-butyl, tri-n-butylstannyl, or triphenylmethyl; or a tautomer of said compound, or a pharmaceutically acceptable salt of said compound or tautomer. The compounds of Formula I are useful for treating hypertension and congestive heart failure. Also disclosed are pharmaceutical compositions containing compounds of Formula I and a pharmaceutically acceptable carrier and methods for production of the compounds of Formula I. Intermediates for making the pharmaceutical useful compounds are also enclosed.