Compostos derivados de piperidinona como inibidores de mdm2 para o tratamento de câncer, composição farmacêutica e uso do referido composto
a presente invenção fornece compostos inibidores de mdm2 de fórmula (i), em que as variáveis são definidas acima, cujos compostos são úteis como agentes terapêuticos, particularmente para o tratamento de cânceres. a presente invenção também está relacionada a composições farmacêuticas que contêm um...
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| creator | EKSTEROWICZ JOHN LIU JIWEN HUANG XIN FISHER BENJAMIN SUN DAQING FU JIASHENG MICHAEL WILLIAM GRIBBLE, JR MCINTOSH JOEL JIAO XIANYUN BRIAN MATTHEW FOX DAVID JOHN KOPECKY JONATHAN DANTE LOW FU ZICE WANG XIAODONG STEVEN HOWARD OLSON LI YIHONG ZHU JIANG MCMINN DUSTIN DUQUETTE JASON MCGEE LAWRENCE HILARY PLAKE BECK JULIO CESAR MEDINA JULIE ANNE HEATH KAYSER FRANK REW YOSUP MA ZHIHUA MICHAEL DAVID BARTBERGER LAI SUJEN FELIX GONZALEZ LOPEZ DE TURISO DEIGNAN JEFFERY BRIAN STUART LUCAS CHEN XIAOQI YAN XUELEI RICHARD VICTOR CONNORS JOHNSON MICHAEL ANA GONZALEZ BUENROSTRO LI ZHIHONG JEFFREY THOMAS MIHALIC YU MING PHILIP MARLEY ROVETO DARIN JAMES GUSTIN WANG YINGCAI |
| description | a presente invenção fornece compostos inibidores de mdm2 de fórmula (i), em que as variáveis são definidas acima, cujos compostos são úteis como agentes terapêuticos, particularmente para o tratamento de cânceres. a presente invenção também está relacionada a composições farmacêuticas que contêm um inibidor de mdm2.
The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor. |
| format | Patent |
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The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220222&DB=EPODOC&CC=BR&NR=122020013151B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220222&DB=EPODOC&CC=BR&NR=122020013151B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>EKSTEROWICZ JOHN</creatorcontrib><creatorcontrib>LIU JIWEN</creatorcontrib><creatorcontrib>HUANG XIN</creatorcontrib><creatorcontrib>FISHER BENJAMIN</creatorcontrib><creatorcontrib>SUN DAQING</creatorcontrib><creatorcontrib>FU JIASHENG</creatorcontrib><creatorcontrib>MICHAEL WILLIAM GRIBBLE, JR</creatorcontrib><creatorcontrib>MCINTOSH JOEL</creatorcontrib><creatorcontrib>JIAO XIANYUN</creatorcontrib><creatorcontrib>BRIAN MATTHEW FOX</creatorcontrib><creatorcontrib>DAVID JOHN KOPECKY</creatorcontrib><creatorcontrib>JONATHAN DANTE LOW</creatorcontrib><creatorcontrib>FU ZICE</creatorcontrib><creatorcontrib>WANG XIAODONG</creatorcontrib><creatorcontrib>STEVEN HOWARD OLSON</creatorcontrib><creatorcontrib>LI YIHONG</creatorcontrib><creatorcontrib>ZHU JIANG</creatorcontrib><creatorcontrib>MCMINN DUSTIN</creatorcontrib><creatorcontrib>DUQUETTE JASON</creatorcontrib><creatorcontrib>MCGEE LAWRENCE</creatorcontrib><creatorcontrib>HILARY PLAKE BECK</creatorcontrib><creatorcontrib>JULIO CESAR MEDINA</creatorcontrib><creatorcontrib>JULIE ANNE HEATH</creatorcontrib><creatorcontrib>KAYSER FRANK</creatorcontrib><creatorcontrib>REW YOSUP</creatorcontrib><creatorcontrib>MA ZHIHUA</creatorcontrib><creatorcontrib>MICHAEL DAVID BARTBERGER</creatorcontrib><creatorcontrib>LAI SUJEN</creatorcontrib><creatorcontrib>FELIX GONZALEZ LOPEZ DE TURISO</creatorcontrib><creatorcontrib>DEIGNAN JEFFERY</creatorcontrib><creatorcontrib>BRIAN STUART LUCAS</creatorcontrib><creatorcontrib>CHEN XIAOQI</creatorcontrib><creatorcontrib>YAN XUELEI</creatorcontrib><creatorcontrib>RICHARD VICTOR CONNORS</creatorcontrib><creatorcontrib>JOHNSON MICHAEL</creatorcontrib><creatorcontrib>ANA GONZALEZ BUENROSTRO</creatorcontrib><creatorcontrib>LI ZHIHONG</creatorcontrib><creatorcontrib>JEFFREY THOMAS MIHALIC</creatorcontrib><creatorcontrib>YU MING</creatorcontrib><creatorcontrib>PHILIP MARLEY ROVETO</creatorcontrib><creatorcontrib>DARIN JAMES GUSTIN</creatorcontrib><creatorcontrib>WANG YINGCAI</creatorcontrib><title>Compostos derivados de piperidinona como inibidores de mdm2 para o tratamento de câncer, composição farmacêutica e uso do referido composto</title><description>a presente invenção fornece compostos inibidores de mdm2 de fórmula (i), em que as variáveis são definidas acima, cujos compostos são úteis como agentes terapêuticos, particularmente para o tratamento de cânceres. a presente invenção também está relacionada a composições farmacêuticas que contêm um inibidor de mdm2.
The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjUEKwjAQRbtxIeodZuNOoUnxAi2Ka3FfxmQKAZMJSeo1vIMuBK-Ri9mWHsDV_OG9mb8sng1bzzFxBE3BPFBPCbzxw6qNY4eg2DIYZ25Gc6CJW20leAwIDClgQksu8UhUfjlFYTdeDZ9N_uQ3Q4fBosrfPhmFQNDHQWYI1I01PMuJ18Wiw3ukzTxXxfZ0vDbnPXluKXpU5Ci19UVIWcqyFJU4iFpU_3o_DiVS3g</recordid><startdate>20220222</startdate><enddate>20220222</enddate><creator>EKSTEROWICZ 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The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compostos derivados de piperidinona como inibidores de mdm2 para o tratamento de câncer, composição farmacêutica e uso do referido composto |
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