Derivados de exatecan e conjugados anticorpo-fármaco destes
derivados de exatecan e conjugados anticorpo-fármaco destes. são revelados nesse relatório descritivo, em parte, novos derivados de exatecan com novos vinculadores químicos que incluem porções cliváveis por catepsina b, e conjugados a anticorpos de direcionamento. Disclosed herein, in part, are comp...
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| creator | STROP PETER JANICA CHEUK-YING WONG VRLJIC MARIJA PONS JAUME |
| description | derivados de exatecan e conjugados anticorpo-fármaco destes. são revelados nesse relatório descritivo, em parte, novos derivados de exatecan com novos vinculadores químicos que incluem porções cliváveis por catepsina b, e conjugados a anticorpos de direcionamento.
Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies. |
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Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Derivados de exatecan e conjugados anticorpo-fármaco destes |
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