PROCESSO PARA A FABRICAÇÃO DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1-IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}-1-(DIFLUOROMETIL)-6-METIL-1,4,7,8,9,10-HEXAIDRO-11,15-(METENO)PIRAZOLO[4,3-B] [1,7]DIAZACICLOTETRADECIN-5(6H)-ONA

PROCESSO PARA A FABRICAÇÃO DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1-IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}-1-(DIFLUOROMETIL)-6-METIL-1,4,7,8,9,10-HEXAIDRO-11,15-(METENO)PIRAZOLO[4,3-B] [1,7]DIAZACICLOTETRADECIN-5(6H)-ONA

PROCESSO PARA A FABRICAÇÃO DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1- IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}-1-(DIFLUOROMETIL)-6- METIL-1,4,7,8,9,10-HEXAIDRO-11,15-(METENO)PIRAZOLO[4,3-B] [1,7]DIAZACICLOTETRADECIN-5(6H)-ONA. A presente invenção refere-se a diversos processos para a prepar...

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Hauptverfasser: NICOLAS CUNIERE, NGOC DUC TRAN, XAVIER JEAN-MARIE JUSSEAU, HELEN Y. LUO, RAMDANE RAHMANI, SÉBASTIEN FRANÇOIS EMMANUEL LEMAIRE, CHRISTOPHER ROBERT JAMISON, CYRIL BEN HAIM, SIMON ALBERT WAGSCHAL, CAROLYN S. WEI, BJÖRN SCHMALZBAUER, AMARJIT SINGH, LUCA ALESSANDRO PEREGO, SUBHA MUKHERJEE, DIEGO FERNANDO DOMENICO BROGGINI, CHRIS SFOUGGATAKIS, BIN ZHENG, DUY CHI TRUNG CAO, PHILIPP KOSCHKER, WILLIAM P. GALLAGHER, KOSTIANTYN CHERNICHENKO, SERGEI KOLOTUCHIN, DIMITRI SKLIAR, STEVEN R. WISNIEWSKI, MARTIN D. EASTGATE, ADRIAN ORTIZ, KARL REUTER, ALEXANDER ZHDANKO, MATTHEW PENFIELD MOWER, KIRAN MATCHA, CHRISTOS XIOURAS
Format: Patent
Sprache:por
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APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PROCESSO PARA A FABRICAÇÃO DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1- IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}-1-(DIFLUOROMETIL)-6- METIL-1,4,7,8,9,10-HEXAIDRO-11,15-(METENO)PIRAZOLO[4,3-B] [1,7]DIAZACICLOTETRADECIN-5(6H)-ONA. A presente invenção refere-se a diversos processos para a preparação de (6R,10S)-10-{4-[5-cloro-2-(4-cloro-1H-1,2,3-triazol-1-il)fenil]-6-oxo-1(6H)-pirimidinil}-1-(difluorometil)-6-metil-1,4,7,8,9,10-hexaidro-11,15-(meteno)pirazolo[4,3-b][1,7]diazaciclotetradecin-5(6H)-ona: The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).