Método para isolar genes tcr

método para isolar genes tcr. a presente invenção fornece métodos para recuperar repertórios de receptores de célula t (tcrs). em algumas modalidades, os repertórios de tcr são recuperados a partir de amostras não viáveis. em algumas modalidades, bibliotecas de pares de tcraß são criadas. em algumas...

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Hauptverfasser:	JEROEN W. J. VAN HEIJST, GAVIN M. BENDLE, JULES F. C. GADIOT, KUILMAN THOMAS, ANTONIUS NICOLAAS MARIA SCHUMACHER, GOMEZ-EERLAND RAQUEL, DEBORAH SOPHIE SCHRIKKEMA, LINNEMANN CARSTEN
Format:	Patent
Sprache:	por
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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creator	JEROEN W. J. VAN HEIJST GAVIN M. BENDLE JULES F. C. GADIOT KUILMAN THOMAS ANTONIUS NICOLAAS MARIA SCHUMACHER GOMEZ-EERLAND RAQUEL DEBORAH SOPHIE SCHRIKKEMA LINNEMANN CARSTEN
description	método para isolar genes tcr. a presente invenção fornece métodos para recuperar repertórios de receptores de célula t (tcrs). em algumas modalidades, os repertórios de tcr são recuperados a partir de amostras não viáveis. em algumas modalidades, bibliotecas de pares de tcraß são criadas. em algumas modalidades, os métodos revelados são usados para imunoterapia de câncer ou para fins de diagnóstico. descritos na presente invenção, em algumas modalidades, são métodos de identificar sequências nucleotídicas codificando cadeias de receptor de células t a (tcra) e tcrß provenientes de uma biblioteca combinatória de ácidos nucleicos. The present disclosure provides methods to recover repertoires of T cell receptors (TCRs). In some embodiments, TCR repertoires are recovered from non-viable samples. In some embodiments, libraries of TCRαβ pairs are created. In some embodiments, the methods disclosed are used for cancer immunotherapy or diagnostic purposes.
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GADIOT ; KUILMAN THOMAS ; ANTONIUS NICOLAAS MARIA SCHUMACHER ; GOMEZ-EERLAND RAQUEL ; DEBORAH SOPHIE SCHRIKKEMA ; LINNEMANN CARSTEN</creatorcontrib><description>método para isolar genes tcr. a presente invenção fornece métodos para recuperar repertórios de receptores de célula t (tcrs). em algumas modalidades, os repertórios de tcr são recuperados a partir de amostras não viáveis. em algumas modalidades, bibliotecas de pares de tcraß são criadas. em algumas modalidades, os métodos revelados são usados para imunoterapia de câncer ou para fins de diagnóstico. descritos na presente invenção, em algumas modalidades, são métodos de identificar sequências nucleotídicas codificando cadeias de receptor de células t a (tcra) e tcrß provenientes de uma biblioteca combinatória de ácidos nucleicos. The present disclosure provides methods to recover repertoires of T cell receptors (TCRs). In some embodiments, TCR repertoires are recovered from non-viable samples. In some embodiments, libraries of TCRαβ pairs are created. In some embodiments, the methods disclosed are used for cancer immunotherapy or diagnostic purposes.</description><language>por</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220412&DB=EPODOC&CC=BR&NR=112022000790A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220412&DB=EPODOC&CC=BR&NR=112022000790A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JEROEN W. J. VAN HEIJST</creatorcontrib><creatorcontrib>GAVIN M. BENDLE</creatorcontrib><creatorcontrib>JULES F. C. GADIOT</creatorcontrib><creatorcontrib>KUILMAN THOMAS</creatorcontrib><creatorcontrib>ANTONIUS NICOLAAS MARIA SCHUMACHER</creatorcontrib><creatorcontrib>GOMEZ-EERLAND RAQUEL</creatorcontrib><creatorcontrib>DEBORAH SOPHIE SCHRIKKEMA</creatorcontrib><creatorcontrib>LINNEMANN CARSTEN</creatorcontrib><title>Método para isolar genes tcr</title><description>método para isolar genes tcr. a presente invenção fornece métodos para recuperar repertórios de receptores de célula t (tcrs). em algumas modalidades, os repertórios de tcr são recuperados a partir de amostras não viáveis. em algumas modalidades, bibliotecas de pares de tcraß são criadas. em algumas modalidades, os métodos revelados são usados para imunoterapia de câncer ou para fins de diagnóstico. descritos na presente invenção, em algumas modalidades, são métodos de identificar sequências nucleotídicas codificando cadeias de receptor de células t a (tcra) e tcrß provenientes de uma biblioteca combinatória de ácidos nucleicos. The present disclosure provides methods to recover repertoires of T cell receptors (TCRs). In some embodiments, TCR repertoires are recovered from non-viable samples. In some embodiments, libraries of TCRαβ pairs are created. 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J. VAN HEIJST</creator><creator>GAVIN M. BENDLE</creator><creator>JULES F. C. GADIOT</creator><creator>KUILMAN THOMAS</creator><creator>ANTONIUS NICOLAAS MARIA SCHUMACHER</creator><creator>GOMEZ-EERLAND RAQUEL</creator><creator>DEBORAH SOPHIE SCHRIKKEMA</creator><creator>LINNEMANN CARSTEN</creator><scope>EVB</scope></search><sort><creationdate>20220412</creationdate><title>Método para isolar genes tcr</title><author>JEROEN W. J. VAN HEIJST ; GAVIN M. BENDLE ; JULES F. C. GADIOT ; KUILMAN THOMAS ; ANTONIUS NICOLAAS MARIA SCHUMACHER ; GOMEZ-EERLAND RAQUEL ; DEBORAH SOPHIE SCHRIKKEMA ; LINNEMANN CARSTEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BR112022000790A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMBINATORIAL CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>JEROEN W. J. VAN HEIJST</creatorcontrib><creatorcontrib>GAVIN M. BENDLE</creatorcontrib><creatorcontrib>JULES F. C. GADIOT</creatorcontrib><creatorcontrib>KUILMAN THOMAS</creatorcontrib><creatorcontrib>ANTONIUS NICOLAAS MARIA SCHUMACHER</creatorcontrib><creatorcontrib>GOMEZ-EERLAND RAQUEL</creatorcontrib><creatorcontrib>DEBORAH SOPHIE SCHRIKKEMA</creatorcontrib><creatorcontrib>LINNEMANN CARSTEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JEROEN W. J. VAN HEIJST</au><au>GAVIN M. BENDLE</au><au>JULES F. C. GADIOT</au><au>KUILMAN THOMAS</au><au>ANTONIUS NICOLAAS MARIA SCHUMACHER</au><au>GOMEZ-EERLAND RAQUEL</au><au>DEBORAH SOPHIE SCHRIKKEMA</au><au>LINNEMANN CARSTEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Método para isolar genes tcr</title><date>2022-04-12</date><risdate>2022</risdate><abstract>método para isolar genes tcr. a presente invenção fornece métodos para recuperar repertórios de receptores de célula t (tcrs). em algumas modalidades, os repertórios de tcr são recuperados a partir de amostras não viáveis. em algumas modalidades, bibliotecas de pares de tcraß são criadas. em algumas modalidades, os métodos revelados são usados para imunoterapia de câncer ou para fins de diagnóstico. descritos na presente invenção, em algumas modalidades, são métodos de identificar sequências nucleotídicas codificando cadeias de receptor de células t a (tcra) e tcrß provenientes de uma biblioteca combinatória de ácidos nucleicos. The present disclosure provides methods to recover repertoires of T cell receptors (TCRs). In some embodiments, TCR repertoires are recovered from non-viable samples. In some embodiments, libraries of TCRαβ pairs are created. In some embodiments, the methods disclosed are used for cancer immunotherapy or diagnostic purposes.</abstract><oa>free_for_read</oa></addata></record>
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
title	Método para isolar genes tcr
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