método para a preparação da 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina
a presente invenção refere-se a um método para a preparação da 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina ("o composto da fórmula (i)" no que se segue), bem como os compostos intermediários úteis na preparação do composto da fórmula (i). a...
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| creator | REINERUS GERARDUS GIELING HENDRICUS NICOLAAS SEBASTIAAN VAN DER HAAS JEROEN ALEXANDER DEKKER JOHANNES PLATZEK SONJA ELISABETH HOOGEVEEN MATTHIJS CORNELIS MARIA VAN OERS PHILIPP RUBENBAUER |
| description | a presente invenção refere-se a um método para a preparação da 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina ("o composto da fórmula (i)" no que se segue), bem como os compostos intermediários úteis na preparação do composto da fórmula (i). a presente invenção também inclui a forma polimórfica b do composto da fórmula (i) com pureza muito alta.
The present invention covers a method for preparing 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine ("the compound of formula (I)" in the following) as well as intermediate compounds useful in the preparation of the compound of formula (I). The present invention also covers polymorphic form B of the compound of formula (I) with very high purity. |
| format | Patent |
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The present invention covers a method for preparing 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine ("the compound of formula (I)" in the following) as well as intermediate compounds useful in the preparation of the compound of formula (I). The present invention also covers polymorphic form B of the compound of formula (I) with very high purity.</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210427&DB=EPODOC&CC=BR&NR=112021001309A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210427&DB=EPODOC&CC=BR&NR=112021001309A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>REINERUS GERARDUS GIELING</creatorcontrib><creatorcontrib>HENDRICUS NICOLAAS SEBASTIAAN VAN DER HAAS</creatorcontrib><creatorcontrib>JEROEN ALEXANDER DEKKER</creatorcontrib><creatorcontrib>JOHANNES PLATZEK</creatorcontrib><creatorcontrib>SONJA ELISABETH HOOGEVEEN</creatorcontrib><creatorcontrib>MATTHIJS CORNELIS MARIA VAN OERS</creatorcontrib><creatorcontrib>PHILIPP RUBENBAUER</creatorcontrib><title>método para a preparação da 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina</title><description>a presente invenção refere-se a um método para a preparação da 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina ("o composto da fórmula (i)" no que se segue), bem como os compostos intermediários úteis na preparação do composto da fórmula (i). a presente invenção também inclui a forma polimórfica b do composto da fórmula (i) com pureza muito alta.
The present invention covers a method for preparing 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine ("the compound of formula (I)" in the following) as well as intermediate compounds useful in the preparation of the compound of formula (I). The present invention also covers polymorphic form B of the compound of formula (I) with very high purity.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZKjJPbyyJD8lX6EgsShRIVGhoCgVxDq8_PDifIWURAUj3WgN4yJNXWPd3NSSzJzc_KK0_JzMPF0T3cycWCCpYQiR0DXM0C3ILEqsys_RNQXKaepaAOXQxQx1zHXzEtNKMosyUzLzEnkYWNMSc4pTeaE0N4Oqm2uIs4duakF-fGpxQWJyal5qSbxTkKGhkYGRoYGBobGBpaORMbHqAHwORbM</recordid><startdate>20210427</startdate><enddate>20210427</enddate><creator>REINERUS GERARDUS GIELING</creator><creator>HENDRICUS NICOLAAS SEBASTIAAN VAN DER HAAS</creator><creator>JEROEN ALEXANDER DEKKER</creator><creator>JOHANNES PLATZEK</creator><creator>SONJA ELISABETH HOOGEVEEN</creator><creator>MATTHIJS CORNELIS MARIA VAN OERS</creator><creator>PHILIPP RUBENBAUER</creator><scope>EVB</scope></search><sort><creationdate>20210427</creationdate><title>método para a preparação da 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina</title><author>REINERUS GERARDUS GIELING ; HENDRICUS NICOLAAS SEBASTIAAN VAN DER HAAS ; JEROEN ALEXANDER DEKKER ; JOHANNES PLATZEK ; SONJA ELISABETH HOOGEVEEN ; MATTHIJS CORNELIS MARIA VAN OERS ; PHILIPP RUBENBAUER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BR112021001309A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>REINERUS GERARDUS GIELING</creatorcontrib><creatorcontrib>HENDRICUS NICOLAAS SEBASTIAAN VAN DER HAAS</creatorcontrib><creatorcontrib>JEROEN ALEXANDER DEKKER</creatorcontrib><creatorcontrib>JOHANNES PLATZEK</creatorcontrib><creatorcontrib>SONJA ELISABETH HOOGEVEEN</creatorcontrib><creatorcontrib>MATTHIJS CORNELIS MARIA VAN OERS</creatorcontrib><creatorcontrib>PHILIPP RUBENBAUER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>REINERUS GERARDUS GIELING</au><au>HENDRICUS NICOLAAS SEBASTIAAN VAN DER HAAS</au><au>JEROEN ALEXANDER DEKKER</au><au>JOHANNES PLATZEK</au><au>SONJA ELISABETH HOOGEVEEN</au><au>MATTHIJS CORNELIS MARIA VAN OERS</au><au>PHILIPP RUBENBAUER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>método para a preparação da 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina</title><date>2021-04-27</date><risdate>2021</risdate><abstract>a presente invenção refere-se a um método para a preparação da 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina ("o composto da fórmula (i)" no que se segue), bem como os compostos intermediários úteis na preparação do composto da fórmula (i). a presente invenção também inclui a forma polimórfica b do composto da fórmula (i) com pureza muito alta.
The present invention covers a method for preparing 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine ("the compound of formula (I)" in the following) as well as intermediate compounds useful in the preparation of the compound of formula (I). The present invention also covers polymorphic form B of the compound of formula (I) with very high purity.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | método para a preparação da 2-[(3r)-3-metilmorfolin-4-il]-4-(1-metil-1h-pirazol-5-il)-8-(1h-pirazol-5-il)-1,7-naftiridina |
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