inibidores macrocíclicos de mcl-1 e métodos de uso
a presente divulgação fornece compostos de fórmula (i), em que a2, a3, a4, a6, a7, a8, a15, ra, r5, r9, r10a, r10b, r11, r12, r13, r14, r16, w, x e y têm qualquer um dos valores definidos no relatório descritivo, e sais farmaceuticamente aceitáveis dos mesmos, que são úteis como agentes para o trata...
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| creator | GEORGE DOHERTY GERARD SULLIVAN ANTHONY MASTRACCHIO WILFRIED BRAJE JESSE TESKE ANDREW SOUERS PATRICK BRADY YIYUN YU YUJIA DAI CHENG JI GUIDONG ZHU ZHI-FU TAO MICHAEL WENDT ROBERTO RISI ANDREW JUDD XILU WANG JANE GONG THOMAS PENNING CHUNQIU LAI KATJA JANTOS AARON KUNZER XIAOHONG SONG |
| description | a presente divulgação fornece compostos de fórmula (i), em que a2, a3, a4, a6, a7, a8, a15, ra, r5, r9, r10a, r10b, r11, r12, r13, r14, r16, w, x e y têm qualquer um dos valores definidos no relatório descritivo, e sais farmaceuticamente aceitáveis dos mesmos, que são úteis como agentes para o tratamento de doenças e afecções, incluindo câncer. também são fornecidas composições farmacêuticas que compreendem compostos de fórmula (i).
The present disclosure provides for compounds of Formula (I)wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I). |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_BR112020003163A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>BR112020003163A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_BR112020003163A23</originalsourceid><addsrcrecordid>eNrjZDDJzMtMykzJL0otVshNTC7KTz68NjknMzm_WCElVSE3OUfXUAFIH15Zkp8CESstzudhYE1LzClO5YXS3Ayqbq4hzh66qQX58anFBYnJqXmpJfFOQYaGRgZGBgYGxoZmxo5GxsSqAwDrZS7n</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>inibidores macrocíclicos de mcl-1 e métodos de uso</title><source>esp@cenet</source><creator>GEORGE DOHERTY ; GERARD SULLIVAN ; ANTHONY MASTRACCHIO ; WILFRIED BRAJE ; JESSE TESKE ; ANDREW SOUERS ; PATRICK BRADY ; YIYUN YU ; YUJIA DAI ; CHENG JI ; GUIDONG ZHU ; ZHI-FU TAO ; MICHAEL WENDT ; ROBERTO RISI ; ANDREW JUDD ; XILU WANG ; JANE GONG ; THOMAS PENNING ; CHUNQIU LAI ; KATJA JANTOS ; AARON KUNZER ; XIAOHONG SONG</creator><creatorcontrib>GEORGE DOHERTY ; GERARD SULLIVAN ; ANTHONY MASTRACCHIO ; WILFRIED BRAJE ; JESSE TESKE ; ANDREW SOUERS ; PATRICK BRADY ; YIYUN YU ; YUJIA DAI ; CHENG JI ; GUIDONG ZHU ; ZHI-FU TAO ; MICHAEL WENDT ; ROBERTO RISI ; ANDREW JUDD ; XILU WANG ; JANE GONG ; THOMAS PENNING ; CHUNQIU LAI ; KATJA JANTOS ; AARON KUNZER ; XIAOHONG SONG</creatorcontrib><description>a presente divulgação fornece compostos de fórmula (i), em que a2, a3, a4, a6, a7, a8, a15, ra, r5, r9, r10a, r10b, r11, r12, r13, r14, r16, w, x e y têm qualquer um dos valores definidos no relatório descritivo, e sais farmaceuticamente aceitáveis dos mesmos, que são úteis como agentes para o tratamento de doenças e afecções, incluindo câncer. também são fornecidas composições farmacêuticas que compreendem compostos de fórmula (i).
The present disclosure provides for compounds of Formula (I)wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200915&DB=EPODOC&CC=BR&NR=112020003163A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25553,76306</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200915&DB=EPODOC&CC=BR&NR=112020003163A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GEORGE DOHERTY</creatorcontrib><creatorcontrib>GERARD SULLIVAN</creatorcontrib><creatorcontrib>ANTHONY MASTRACCHIO</creatorcontrib><creatorcontrib>WILFRIED BRAJE</creatorcontrib><creatorcontrib>JESSE TESKE</creatorcontrib><creatorcontrib>ANDREW SOUERS</creatorcontrib><creatorcontrib>PATRICK BRADY</creatorcontrib><creatorcontrib>YIYUN YU</creatorcontrib><creatorcontrib>YUJIA DAI</creatorcontrib><creatorcontrib>CHENG JI</creatorcontrib><creatorcontrib>GUIDONG ZHU</creatorcontrib><creatorcontrib>ZHI-FU TAO</creatorcontrib><creatorcontrib>MICHAEL WENDT</creatorcontrib><creatorcontrib>ROBERTO RISI</creatorcontrib><creatorcontrib>ANDREW JUDD</creatorcontrib><creatorcontrib>XILU WANG</creatorcontrib><creatorcontrib>JANE GONG</creatorcontrib><creatorcontrib>THOMAS PENNING</creatorcontrib><creatorcontrib>CHUNQIU LAI</creatorcontrib><creatorcontrib>KATJA JANTOS</creatorcontrib><creatorcontrib>AARON KUNZER</creatorcontrib><creatorcontrib>XIAOHONG SONG</creatorcontrib><title>inibidores macrocíclicos de mcl-1 e métodos de uso</title><description>a presente divulgação fornece compostos de fórmula (i), em que a2, a3, a4, a6, a7, a8, a15, ra, r5, r9, r10a, r10b, r11, r12, r13, r14, r16, w, x e y têm qualquer um dos valores definidos no relatório descritivo, e sais farmaceuticamente aceitáveis dos mesmos, que são úteis como agentes para o tratamento de doenças e afecções, incluindo câncer. também são fornecidas composições farmacêuticas que compreendem compostos de fórmula (i).
The present disclosure provides for compounds of Formula (I)wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDJzMtMykzJL0otVshNTC7KTz68NjknMzm_WCElVSE3OUfXUAFIH15Zkp8CESstzudhYE1LzClO5YXS3Ayqbq4hzh66qQX58anFBYnJqXmpJfFOQYaGRgZGBgYGxoZmxo5GxsSqAwDrZS7n</recordid><startdate>20200915</startdate><enddate>20200915</enddate><creator>GEORGE DOHERTY</creator><creator>GERARD SULLIVAN</creator><creator>ANTHONY MASTRACCHIO</creator><creator>WILFRIED BRAJE</creator><creator>JESSE TESKE</creator><creator>ANDREW SOUERS</creator><creator>PATRICK BRADY</creator><creator>YIYUN YU</creator><creator>YUJIA DAI</creator><creator>CHENG JI</creator><creator>GUIDONG ZHU</creator><creator>ZHI-FU TAO</creator><creator>MICHAEL WENDT</creator><creator>ROBERTO RISI</creator><creator>ANDREW JUDD</creator><creator>XILU WANG</creator><creator>JANE GONG</creator><creator>THOMAS PENNING</creator><creator>CHUNQIU LAI</creator><creator>KATJA JANTOS</creator><creator>AARON KUNZER</creator><creator>XIAOHONG SONG</creator><scope>EVB</scope></search><sort><creationdate>20200915</creationdate><title>inibidores macrocíclicos de mcl-1 e métodos de uso</title><author>GEORGE DOHERTY ; GERARD SULLIVAN ; ANTHONY MASTRACCHIO ; WILFRIED BRAJE ; JESSE TESKE ; ANDREW SOUERS ; PATRICK BRADY ; YIYUN YU ; YUJIA DAI ; CHENG JI ; GUIDONG ZHU ; ZHI-FU TAO ; MICHAEL WENDT ; ROBERTO RISI ; ANDREW JUDD ; XILU WANG ; JANE GONG ; THOMAS PENNING ; CHUNQIU LAI ; KATJA JANTOS ; AARON KUNZER ; XIAOHONG SONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BR112020003163A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GEORGE DOHERTY</creatorcontrib><creatorcontrib>GERARD SULLIVAN</creatorcontrib><creatorcontrib>ANTHONY MASTRACCHIO</creatorcontrib><creatorcontrib>WILFRIED BRAJE</creatorcontrib><creatorcontrib>JESSE TESKE</creatorcontrib><creatorcontrib>ANDREW SOUERS</creatorcontrib><creatorcontrib>PATRICK BRADY</creatorcontrib><creatorcontrib>YIYUN YU</creatorcontrib><creatorcontrib>YUJIA DAI</creatorcontrib><creatorcontrib>CHENG JI</creatorcontrib><creatorcontrib>GUIDONG ZHU</creatorcontrib><creatorcontrib>ZHI-FU TAO</creatorcontrib><creatorcontrib>MICHAEL WENDT</creatorcontrib><creatorcontrib>ROBERTO RISI</creatorcontrib><creatorcontrib>ANDREW JUDD</creatorcontrib><creatorcontrib>XILU WANG</creatorcontrib><creatorcontrib>JANE GONG</creatorcontrib><creatorcontrib>THOMAS PENNING</creatorcontrib><creatorcontrib>CHUNQIU LAI</creatorcontrib><creatorcontrib>KATJA JANTOS</creatorcontrib><creatorcontrib>AARON KUNZER</creatorcontrib><creatorcontrib>XIAOHONG SONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GEORGE DOHERTY</au><au>GERARD SULLIVAN</au><au>ANTHONY MASTRACCHIO</au><au>WILFRIED BRAJE</au><au>JESSE TESKE</au><au>ANDREW SOUERS</au><au>PATRICK BRADY</au><au>YIYUN YU</au><au>YUJIA DAI</au><au>CHENG JI</au><au>GUIDONG ZHU</au><au>ZHI-FU TAO</au><au>MICHAEL WENDT</au><au>ROBERTO RISI</au><au>ANDREW JUDD</au><au>XILU WANG</au><au>JANE GONG</au><au>THOMAS PENNING</au><au>CHUNQIU LAI</au><au>KATJA JANTOS</au><au>AARON KUNZER</au><au>XIAOHONG SONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>inibidores macrocíclicos de mcl-1 e métodos de uso</title><date>2020-09-15</date><risdate>2020</risdate><abstract>a presente divulgação fornece compostos de fórmula (i), em que a2, a3, a4, a6, a7, a8, a15, ra, r5, r9, r10a, r10b, r11, r12, r13, r14, r16, w, x e y têm qualquer um dos valores definidos no relatório descritivo, e sais farmaceuticamente aceitáveis dos mesmos, que são úteis como agentes para o tratamento de doenças e afecções, incluindo câncer. também são fornecidas composições farmacêuticas que compreendem compostos de fórmula (i).
The present disclosure provides for compounds of Formula (I)wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | inibidores macrocíclicos de mcl-1 e métodos de uso |
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