DERIVADOS DE IMIDAZOL PENTACÍCLICO FUNDIDO, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO OS MESMOS E USO DOS MESMOS
Uma série de derivados de imidazol pentacíclico fundido, sendo moduladores potentes da atividade de TNFa humano, são consequentemente de benefício no tratamento e/ou prevenção de várias indisposições humanas, incluindo distúrbios autoimunes e inflamatórios; distúrbios neurológicos e neurodegenerativ...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | por |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | JEAN KEYAERTS DOMINIQUE LOUIS LÉON SWINNEN TERESA DE HARO GARCIA ZHAONING ZHU MENGYANG XUAN MALCOLM MAC COSS YVES EVRARD YANN FORICHER JAMES ANDREW JOHNSON SOPHIE JADOT JOANNA RACHEL QUINCEY DANIEL CHRISTOPHER BROOKINGS MICHAEL DELIGNY JAG PAUL HEER BRUNO FILOCHE-ROMME MARK DANIEL CALMIANO MATTHEW DUNCAN SELBY MICHAEL ALAN SHAW LAURENT SCHIO MARTIN CLIVE HUTCHINGS |
| description | Uma série de derivados de imidazol pentacíclico fundido, sendo moduladores potentes da atividade de TNFa humano, são consequentemente de benefício no tratamento e/ou prevenção de várias indisposições humanas, incluindo distúrbios autoimunes e inflamatórios; distúrbios neurológicos e neurodegenerativos; dor e distúrbios nociceptivos; distúrbios cardiovasculares; distúrbios metabólicos; distúrbios oculares e distúrbios oncológicos. Em particular, a presente invenção está relacionada com derivados de 6,7-dihidro-7,14-metanobenzimidazo[1,2-b][2,5] benzodiazocin-5(14H)-ona e análogos dos mesmos.
A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_BR112017006669B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>BR112017006669B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_BR112017006669B13</originalsourceid><addsrcrecordid>eNrjZChwcQ3yDHN08Q9WcHFV8PT1dHGM8vdRCHD1C3F0Ptzr7OPp7K_gFurn4unir6Pg7O8b4B_sebj9cDNQ1DHIF6imKzTE09kRLBXk6urnAkT-CkDjfF2DfYGUq0JosL-CC1yAh4E1LTGnOJUXSnMzqLq5hjh76KYW5MenFhckJqfmpZbEOwUZGhoZGJobGJiZmVk6GRoTqw4AXlU8WQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>DERIVADOS DE IMIDAZOL PENTACÍCLICO FUNDIDO, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO OS MESMOS E USO DOS MESMOS</title><source>esp@cenet</source><creator>JEAN KEYAERTS ; DOMINIQUE LOUIS LÉON SWINNEN ; TERESA DE HARO GARCIA ; ZHAONING ZHU ; MENGYANG XUAN ; MALCOLM MAC COSS ; YVES EVRARD ; YANN FORICHER ; JAMES ANDREW JOHNSON ; SOPHIE JADOT ; JOANNA RACHEL QUINCEY ; DANIEL CHRISTOPHER BROOKINGS ; MICHAEL DELIGNY ; JAG PAUL HEER ; BRUNO FILOCHE-ROMME ; MARK DANIEL CALMIANO ; MATTHEW DUNCAN SELBY ; MICHAEL ALAN SHAW ; LAURENT SCHIO ; MARTIN CLIVE HUTCHINGS</creator><creatorcontrib>JEAN KEYAERTS ; DOMINIQUE LOUIS LÉON SWINNEN ; TERESA DE HARO GARCIA ; ZHAONING ZHU ; MENGYANG XUAN ; MALCOLM MAC COSS ; YVES EVRARD ; YANN FORICHER ; JAMES ANDREW JOHNSON ; SOPHIE JADOT ; JOANNA RACHEL QUINCEY ; DANIEL CHRISTOPHER BROOKINGS ; MICHAEL DELIGNY ; JAG PAUL HEER ; BRUNO FILOCHE-ROMME ; MARK DANIEL CALMIANO ; MATTHEW DUNCAN SELBY ; MICHAEL ALAN SHAW ; LAURENT SCHIO ; MARTIN CLIVE HUTCHINGS</creatorcontrib><description>Uma série de derivados de imidazol pentacíclico fundido, sendo moduladores potentes da atividade de TNFa humano, são consequentemente de benefício no tratamento e/ou prevenção de várias indisposições humanas, incluindo distúrbios autoimunes e inflamatórios; distúrbios neurológicos e neurodegenerativos; dor e distúrbios nociceptivos; distúrbios cardiovasculares; distúrbios metabólicos; distúrbios oculares e distúrbios oncológicos. Em particular, a presente invenção está relacionada com derivados de 6,7-dihidro-7,14-metanobenzimidazo[1,2-b][2,5] benzodiazocin-5(14H)-ona e análogos dos mesmos.
A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230418&DB=EPODOC&CC=BR&NR=112017006669B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230418&DB=EPODOC&CC=BR&NR=112017006669B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JEAN KEYAERTS</creatorcontrib><creatorcontrib>DOMINIQUE LOUIS LÉON SWINNEN</creatorcontrib><creatorcontrib>TERESA DE HARO GARCIA</creatorcontrib><creatorcontrib>ZHAONING ZHU</creatorcontrib><creatorcontrib>MENGYANG XUAN</creatorcontrib><creatorcontrib>MALCOLM MAC COSS</creatorcontrib><creatorcontrib>YVES EVRARD</creatorcontrib><creatorcontrib>YANN FORICHER</creatorcontrib><creatorcontrib>JAMES ANDREW JOHNSON</creatorcontrib><creatorcontrib>SOPHIE JADOT</creatorcontrib><creatorcontrib>JOANNA RACHEL QUINCEY</creatorcontrib><creatorcontrib>DANIEL CHRISTOPHER BROOKINGS</creatorcontrib><creatorcontrib>MICHAEL DELIGNY</creatorcontrib><creatorcontrib>JAG PAUL HEER</creatorcontrib><creatorcontrib>BRUNO FILOCHE-ROMME</creatorcontrib><creatorcontrib>MARK DANIEL CALMIANO</creatorcontrib><creatorcontrib>MATTHEW DUNCAN SELBY</creatorcontrib><creatorcontrib>MICHAEL ALAN SHAW</creatorcontrib><creatorcontrib>LAURENT SCHIO</creatorcontrib><creatorcontrib>MARTIN CLIVE HUTCHINGS</creatorcontrib><title>DERIVADOS DE IMIDAZOL PENTACÍCLICO FUNDIDO, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO OS MESMOS E USO DOS MESMOS</title><description>Uma série de derivados de imidazol pentacíclico fundido, sendo moduladores potentes da atividade de TNFa humano, são consequentemente de benefício no tratamento e/ou prevenção de várias indisposições humanas, incluindo distúrbios autoimunes e inflamatórios; distúrbios neurológicos e neurodegenerativos; dor e distúrbios nociceptivos; distúrbios cardiovasculares; distúrbios metabólicos; distúrbios oculares e distúrbios oncológicos. Em particular, a presente invenção está relacionada com derivados de 6,7-dihidro-7,14-metanobenzimidazo[1,2-b][2,5] benzodiazocin-5(14H)-ona e análogos dos mesmos.
A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZChwcQ3yDHN08Q9WcHFV8PT1dHGM8vdRCHD1C3F0Ptzr7OPp7K_gFurn4unir6Pg7O8b4B_sebj9cDNQ1DHIF6imKzTE09kRLBXk6urnAkT-CkDjfF2DfYGUq0JosL-CC1yAh4E1LTGnOJUXSnMzqLq5hjh76KYW5MenFhckJqfmpZbEOwUZGhoZGJobGJiZmVk6GRoTqw4AXlU8WQ</recordid><startdate>20230418</startdate><enddate>20230418</enddate><creator>JEAN KEYAERTS</creator><creator>DOMINIQUE LOUIS LÉON SWINNEN</creator><creator>TERESA DE HARO GARCIA</creator><creator>ZHAONING ZHU</creator><creator>MENGYANG XUAN</creator><creator>MALCOLM MAC COSS</creator><creator>YVES EVRARD</creator><creator>YANN FORICHER</creator><creator>JAMES ANDREW JOHNSON</creator><creator>SOPHIE JADOT</creator><creator>JOANNA RACHEL QUINCEY</creator><creator>DANIEL CHRISTOPHER BROOKINGS</creator><creator>MICHAEL DELIGNY</creator><creator>JAG PAUL HEER</creator><creator>BRUNO FILOCHE-ROMME</creator><creator>MARK DANIEL CALMIANO</creator><creator>MATTHEW DUNCAN SELBY</creator><creator>MICHAEL ALAN SHAW</creator><creator>LAURENT SCHIO</creator><creator>MARTIN CLIVE HUTCHINGS</creator><scope>EVB</scope></search><sort><creationdate>20230418</creationdate><title>DERIVADOS DE IMIDAZOL PENTACÍCLICO FUNDIDO, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO OS MESMOS E USO DOS MESMOS</title><author>JEAN KEYAERTS ; DOMINIQUE LOUIS LÉON SWINNEN ; TERESA DE HARO GARCIA ; ZHAONING ZHU ; MENGYANG XUAN ; MALCOLM MAC COSS ; YVES EVRARD ; YANN FORICHER ; JAMES ANDREW JOHNSON ; SOPHIE JADOT ; JOANNA RACHEL QUINCEY ; DANIEL CHRISTOPHER BROOKINGS ; MICHAEL DELIGNY ; JAG PAUL HEER ; BRUNO FILOCHE-ROMME ; MARK DANIEL CALMIANO ; MATTHEW DUNCAN SELBY ; MICHAEL ALAN SHAW ; LAURENT SCHIO ; MARTIN CLIVE HUTCHINGS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BR112017006669B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JEAN KEYAERTS</creatorcontrib><creatorcontrib>DOMINIQUE LOUIS LÉON SWINNEN</creatorcontrib><creatorcontrib>TERESA DE HARO GARCIA</creatorcontrib><creatorcontrib>ZHAONING ZHU</creatorcontrib><creatorcontrib>MENGYANG XUAN</creatorcontrib><creatorcontrib>MALCOLM MAC COSS</creatorcontrib><creatorcontrib>YVES EVRARD</creatorcontrib><creatorcontrib>YANN FORICHER</creatorcontrib><creatorcontrib>JAMES ANDREW JOHNSON</creatorcontrib><creatorcontrib>SOPHIE JADOT</creatorcontrib><creatorcontrib>JOANNA RACHEL QUINCEY</creatorcontrib><creatorcontrib>DANIEL CHRISTOPHER BROOKINGS</creatorcontrib><creatorcontrib>MICHAEL DELIGNY</creatorcontrib><creatorcontrib>JAG PAUL HEER</creatorcontrib><creatorcontrib>BRUNO FILOCHE-ROMME</creatorcontrib><creatorcontrib>MARK DANIEL CALMIANO</creatorcontrib><creatorcontrib>MATTHEW DUNCAN SELBY</creatorcontrib><creatorcontrib>MICHAEL ALAN SHAW</creatorcontrib><creatorcontrib>LAURENT SCHIO</creatorcontrib><creatorcontrib>MARTIN CLIVE HUTCHINGS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JEAN KEYAERTS</au><au>DOMINIQUE LOUIS LÉON SWINNEN</au><au>TERESA DE HARO GARCIA</au><au>ZHAONING ZHU</au><au>MENGYANG XUAN</au><au>MALCOLM MAC COSS</au><au>YVES EVRARD</au><au>YANN FORICHER</au><au>JAMES ANDREW JOHNSON</au><au>SOPHIE JADOT</au><au>JOANNA RACHEL QUINCEY</au><au>DANIEL CHRISTOPHER BROOKINGS</au><au>MICHAEL DELIGNY</au><au>JAG PAUL HEER</au><au>BRUNO FILOCHE-ROMME</au><au>MARK DANIEL CALMIANO</au><au>MATTHEW DUNCAN SELBY</au><au>MICHAEL ALAN SHAW</au><au>LAURENT SCHIO</au><au>MARTIN CLIVE HUTCHINGS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DERIVADOS DE IMIDAZOL PENTACÍCLICO FUNDIDO, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO OS MESMOS E USO DOS MESMOS</title><date>2023-04-18</date><risdate>2023</risdate><abstract>Uma série de derivados de imidazol pentacíclico fundido, sendo moduladores potentes da atividade de TNFa humano, são consequentemente de benefício no tratamento e/ou prevenção de várias indisposições humanas, incluindo distúrbios autoimunes e inflamatórios; distúrbios neurológicos e neurodegenerativos; dor e distúrbios nociceptivos; distúrbios cardiovasculares; distúrbios metabólicos; distúrbios oculares e distúrbios oncológicos. Em particular, a presente invenção está relacionada com derivados de 6,7-dihidro-7,14-metanobenzimidazo[1,2-b][2,5] benzodiazocin-5(14H)-ona e análogos dos mesmos.
A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | por |
| recordid | cdi_epo_espacenet_BR112017006669B1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DERIVADOS DE IMIDAZOL PENTACÍCLICO FUNDIDO, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO OS MESMOS E USO DOS MESMOS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T11%3A35%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=JEAN%20KEYAERTS&rft.date=2023-04-18&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EBR112017006669B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |