inibidores de pirrolo[2,3 - b] piridina cdk9 kinase

resumo “inibidores de pirrolo[2,3 – b] piridina cdk9 kinase” são descritos compostos da formula (iia), em que r1, r2, r3a, r3b, r3c, r3d, r3e e r4 são definidos como no relatório descritivo e sais farmaceuticamente aceitáveis do mesmo. os compostos podem ser usados como agentes no tratamento de doen...

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Hauptverfasser:	JULIEM MIYASHIRO, YUNSONG TONG, ALAN S. FLORJANCIC, ANTHONY MASTRACCHIO, RICHARD F. CLARK, ROBIN R. FREY, TODD M. HANSEN, MICHAEL L. CURTIN, RAJEEV GOSWAMI, GUIDONG ZHU, MICHAEL MICHAELIDES, KEITH W. WOODS, OMPRAKASH REDDY IQUTURI, ZHI-FU TAO, ROBERTO M. RISI, THOMAS PENNING, CHUNQIU LAI, ZHIQIN JI, JIANCHUN GONG, MADHU BABU DABBEERU, XIAOHONG SONG, MILAN BRUNCKO
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Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	JULIEM MIYASHIRO YUNSONG TONG ALAN S. FLORJANCIC ANTHONY MASTRACCHIO RICHARD F. CLARK ROBIN R. FREY TODD M. HANSEN MICHAEL L. CURTIN RAJEEV GOSWAMI GUIDONG ZHU MICHAEL MICHAELIDES KEITH W. WOODS OMPRAKASH REDDY IQUTURI ZHI-FU TAO ROBERTO M. RISI THOMAS PENNING CHUNQIU LAI ZHIQIN JI JIANCHUN GONG MADHU BABU DABBEERU XIAOHONG SONG MILAN BRUNCKO
description	resumo “inibidores de pirrolo[2,3 – b] piridina cdk9 kinase” são descritos compostos da formula (iia), em que r1, r2, r3a, r3b, r3c, r3d, r3e e r4 são definidos como no relatório descritivo e sais farmaceuticamente aceitáveis do mesmo. os compostos podem ser usados como agentes no tratamento de doenças, incluindo câncer. também são fornecidas composições farmacêuticas compreendendo um ou mais composto da formula (iia). fórmula (iia), Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).
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RISI ; THOMAS PENNING ; CHUNQIU LAI ; ZHIQIN JI ; JIANCHUN GONG ; MADHU BABU DABBEERU ; XIAOHONG SONG ; MILAN BRUNCKO</creator><creatorcontrib>JULIEM MIYASHIRO ; YUNSONG TONG ; ALAN S. FLORJANCIC ; ANTHONY MASTRACCHIO ; RICHARD F. CLARK ; ROBIN R. FREY ; TODD M. HANSEN ; MICHAEL L. CURTIN ; RAJEEV GOSWAMI ; GUIDONG ZHU ; MICHAEL MICHAELIDES ; KEITH W. WOODS ; OMPRAKASH REDDY IQUTURI ; ZHI-FU TAO ; ROBERTO M. RISI ; THOMAS PENNING ; CHUNQIU LAI ; ZHIQIN JI ; JIANCHUN GONG ; MADHU BABU DABBEERU ; XIAOHONG SONG ; MILAN BRUNCKO</creatorcontrib><description>resumo “inibidores de pirrolo[2,3 – b] piridina cdk9 kinase” são descritos compostos da formula (iia), em que r1, r2, r3a, r3b, r3c, r3d, r3e e r4 são definidos como no relatório descritivo e sais farmaceuticamente aceitáveis do mesmo. os compostos podem ser usados como agentes no tratamento de doenças, incluindo câncer. também são fornecidas composições farmacêuticas compreendendo um ou mais composto da formula (iia). fórmula (iia), Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170718&DB=EPODOC&CC=BR&NR=112015023187A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170718&DB=EPODOC&CC=BR&NR=112015023187A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JULIEM MIYASHIRO</creatorcontrib><creatorcontrib>YUNSONG TONG</creatorcontrib><creatorcontrib>ALAN S. FLORJANCIC</creatorcontrib><creatorcontrib>ANTHONY MASTRACCHIO</creatorcontrib><creatorcontrib>RICHARD F. CLARK</creatorcontrib><creatorcontrib>ROBIN R. FREY</creatorcontrib><creatorcontrib>TODD M. HANSEN</creatorcontrib><creatorcontrib>MICHAEL L. CURTIN</creatorcontrib><creatorcontrib>RAJEEV GOSWAMI</creatorcontrib><creatorcontrib>GUIDONG ZHU</creatorcontrib><creatorcontrib>MICHAEL MICHAELIDES</creatorcontrib><creatorcontrib>KEITH W. WOODS</creatorcontrib><creatorcontrib>OMPRAKASH REDDY IQUTURI</creatorcontrib><creatorcontrib>ZHI-FU TAO</creatorcontrib><creatorcontrib>ROBERTO M. RISI</creatorcontrib><creatorcontrib>THOMAS PENNING</creatorcontrib><creatorcontrib>CHUNQIU LAI</creatorcontrib><creatorcontrib>ZHIQIN JI</creatorcontrib><creatorcontrib>JIANCHUN GONG</creatorcontrib><creatorcontrib>MADHU BABU DABBEERU</creatorcontrib><creatorcontrib>XIAOHONG SONG</creatorcontrib><creatorcontrib>MILAN BRUNCKO</creatorcontrib><title>inibidores de pirrolo[2,3 - b] piridina cdk9 kinase</title><description>resumo “inibidores de pirrolo[2,3 – b] piridina cdk9 kinase” são descritos compostos da formula (iia), em que r1, r2, r3a, r3b, r3c, r3d, r3e e r4 são definidos como no relatório descritivo e sais farmaceuticamente aceitáveis do mesmo. os compostos podem ser usados como agentes no tratamento de doenças, incluindo câncer. também são fornecidas composições farmacêuticas compreendendo um ou mais composto da formula (iia). fórmula (iia), Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. 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CURTIN ; RAJEEV GOSWAMI ; GUIDONG ZHU ; MICHAEL MICHAELIDES ; KEITH W. WOODS ; OMPRAKASH REDDY IQUTURI ; ZHI-FU TAO ; ROBERTO M. RISI ; THOMAS PENNING ; CHUNQIU LAI ; ZHIQIN JI ; JIANCHUN GONG ; MADHU BABU DABBEERU ; XIAOHONG SONG ; MILAN BRUNCKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BR112015023187A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JULIEM MIYASHIRO</creatorcontrib><creatorcontrib>YUNSONG TONG</creatorcontrib><creatorcontrib>ALAN S. FLORJANCIC</creatorcontrib><creatorcontrib>ANTHONY MASTRACCHIO</creatorcontrib><creatorcontrib>RICHARD F. 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RISI</creatorcontrib><creatorcontrib>THOMAS PENNING</creatorcontrib><creatorcontrib>CHUNQIU LAI</creatorcontrib><creatorcontrib>ZHIQIN JI</creatorcontrib><creatorcontrib>JIANCHUN GONG</creatorcontrib><creatorcontrib>MADHU BABU DABBEERU</creatorcontrib><creatorcontrib>XIAOHONG SONG</creatorcontrib><creatorcontrib>MILAN BRUNCKO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JULIEM MIYASHIRO</au><au>YUNSONG TONG</au><au>ALAN S. FLORJANCIC</au><au>ANTHONY MASTRACCHIO</au><au>RICHARD F. CLARK</au><au>ROBIN R. FREY</au><au>TODD M. HANSEN</au><au>MICHAEL L. CURTIN</au><au>RAJEEV GOSWAMI</au><au>GUIDONG ZHU</au><au>MICHAEL MICHAELIDES</au><au>KEITH W. WOODS</au><au>OMPRAKASH REDDY IQUTURI</au><au>ZHI-FU TAO</au><au>ROBERTO M. RISI</au><au>THOMAS PENNING</au><au>CHUNQIU LAI</au><au>ZHIQIN JI</au><au>JIANCHUN GONG</au><au>MADHU BABU DABBEERU</au><au>XIAOHONG SONG</au><au>MILAN BRUNCKO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>inibidores de pirrolo[2,3 - b] piridina cdk9 kinase</title><date>2017-07-18</date><risdate>2017</risdate><abstract>resumo “inibidores de pirrolo[2,3 – b] piridina cdk9 kinase” são descritos compostos da formula (iia), em que r1, r2, r3a, r3b, r3c, r3d, r3e e r4 são definidos como no relatório descritivo e sais farmaceuticamente aceitáveis do mesmo. os compostos podem ser usados como agentes no tratamento de doenças, incluindo câncer. também são fornecidas composições farmacêuticas compreendendo um ou mais composto da formula (iia). fórmula (iia), Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).</abstract><oa>free_for_read</oa></addata></record>
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title	inibidores de pirrolo[2,3 - b] piridina cdk9 kinase
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