método para a preparação de ticagrelor, e, composto
1 / 1 resumo âmãtodo para a preparaãão de ticagrelor, e, compostoâ um mã©todo para a preparaã§ã£o de ticagrelor da fã³rmula i, em que a reaã§ã£o chave de toda a sãntese ã© condensaã§ã£o de um amino ciclopentano diol com pirimidina, fornecendo o intermediã¡rio isolado da fã³rmula iv. o amino...
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| creator | Jaroslav Riha Iva Obadalova Ivo Strelec Vaclav Krampera |
| description | 1 / 1 resumo âmãtodo para a preparaãão de ticagrelor, e, compostoâ um mã©todo para a preparaã§ã£o de ticagrelor da fã³rmula i, em que a reaã§ã£o chave de toda a sãntese ã© condensaã§ã£o de um amino ciclopentano diol com pirimidina, fornecendo o intermediã¡rio isolado da fã³rmula iv. o amino cicloarpentano diol ã© usado para a reaã§ã£o com pirimidina sem nenhum grupo protetor nas hidroxilas nas posiã§ãµes 1 e 2. o uso do composto sem um grupo protetor elimina a necessidade de desproteã§ã£o nas subsequentes etapas sintã©ticas.
A method for the preparation of ticagrelor of formula I, wherein the key reaction of the entire synthesis is condensation of an amino cyclopentane diol with pyrimidine, providing the isolated intermediate of formula IV. The amino cyclopentane diol is used for the reaction with pyrimidine without any protecting group on the hydroxyls in positions 1 and 2. Using the compound without a protecting group eliminates the necessity of deprotection in the subsequent synthetic steps. |
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A method for the preparation of ticagrelor of formula I, wherein the key reaction of the entire synthesis is condensation of an amino cyclopentane diol with pyrimidine, providing the isolated intermediate of formula IV. The amino cyclopentane diol is used for the reaction with pyrimidine without any protecting group on the hydroxyls in positions 1 and 2. Using the compound without a protecting group eliminates the necessity of deprotection in the subsequent synthetic steps.</description><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170718&DB=EPODOC&CC=BR&NR=112015022692A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170718&DB=EPODOC&CC=BR&NR=112015022692A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Jaroslav Riha</creatorcontrib><creatorcontrib>Iva Obadalova</creatorcontrib><creatorcontrib>Ivo Strelec</creatorcontrib><creatorcontrib>Vaclav Krampera</creatorcontrib><title>método para a preparação de ticagrelor, e, composto</title><description>1 / 1 resumo âmãtodo para a preparaãão de ticagrelor, e, compostoâ um mã©todo para a preparaã§ã£o de ticagrelor da fã³rmula i, em que a reaã§ã£o chave de toda a sãntese ã© condensaã§ã£o de um amino ciclopentano diol com pirimidina, fornecendo o intermediã¡rio isolado da fã³rmula iv. o amino cicloarpentano diol ã© usado para a reaã§ã£o com pirimidina sem nenhum grupo protetor nas hidroxilas nas posiã§ãµes 1 e 2. o uso do composto sem um grupo protetor elimina a necessidade de desproteã§ã£o nas subsequentes etapas sintã©ticas.
A method for the preparation of ticagrelor of formula I, wherein the key reaction of the entire synthesis is condensation of an amino cyclopentane diol with pyrimidine, providing the isolated intermediate of formula IV. The amino cyclopentane diol is used for the reaction with pyrimidine without any protecting group on the hydroxyls in positions 1 and 2. Using the compound without a protecting group eliminates the necessity of deprotection in the subsequent synthetic steps.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDLPbyyJD8lX6EgsShRIVGhoCgVxDq8_PDifIWUVIWSzOTE9KLUnPwiHYVUHYXk_NyC_OKSfB4G1rTEnOJUXijNzaDq5hri7KGbWpAfn1pckJicmpdaEu8UZGhoZGBoamBkZGZp5GhkTKw6AMAHMHE</recordid><startdate>20170718</startdate><enddate>20170718</enddate><creator>Jaroslav Riha</creator><creator>Iva Obadalova</creator><creator>Ivo Strelec</creator><creator>Vaclav Krampera</creator><scope>EVB</scope></search><sort><creationdate>20170718</creationdate><title>método para a preparação de ticagrelor, e, composto</title><author>Jaroslav Riha ; Iva Obadalova ; Ivo Strelec ; Vaclav Krampera</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BR112015022692A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>Jaroslav Riha</creatorcontrib><creatorcontrib>Iva Obadalova</creatorcontrib><creatorcontrib>Ivo Strelec</creatorcontrib><creatorcontrib>Vaclav Krampera</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Jaroslav Riha</au><au>Iva Obadalova</au><au>Ivo Strelec</au><au>Vaclav Krampera</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>método para a preparação de ticagrelor, e, composto</title><date>2017-07-18</date><risdate>2017</risdate><abstract>1 / 1 resumo âmãtodo para a preparaãão de ticagrelor, e, compostoâ um mã©todo para a preparaã§ã£o de ticagrelor da fã³rmula i, em que a reaã§ã£o chave de toda a sãntese ã© condensaã§ã£o de um amino ciclopentano diol com pirimidina, fornecendo o intermediã¡rio isolado da fã³rmula iv. o amino cicloarpentano diol ã© usado para a reaã§ã£o com pirimidina sem nenhum grupo protetor nas hidroxilas nas posiã§ãµes 1 e 2. o uso do composto sem um grupo protetor elimina a necessidade de desproteã§ã£o nas subsequentes etapas sintã©ticas.
A method for the preparation of ticagrelor of formula I, wherein the key reaction of the entire synthesis is condensation of an amino cyclopentane diol with pyrimidine, providing the isolated intermediate of formula IV. The amino cyclopentane diol is used for the reaction with pyrimidine without any protecting group on the hydroxyls in positions 1 and 2. Using the compound without a protecting group eliminates the necessity of deprotection in the subsequent synthetic steps.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | método para a preparação de ticagrelor, e, composto |
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