construto e proteína aglutinantes ao antígeno, dímero, composição farmacêutica, sequência de polinucleotídeo, célula hospedeira e, método para produção do construto

The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	ALAN PETER LEWIS, ZOE HUGHES-THOMAS, IAN RICHARD CATCHPOLE, MICHAEL STEWARD, CLAIRE ASHMAN
Format:	Patent
Sprache:	por
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	ALAN PETER LEWIS ZOE HUGHES-THOMAS IAN RICHARD CATCHPOLE MICHAEL STEWARD CLAIRE ASHMAN
description	The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularization, and polynucleotide sequences encoding said antigen binding constructs.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_BR112014001855A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>BR112014001855A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_BR112014001855A23</originalsourceid><addsrcrecordid>eNqNjr1qw0AQhNW4ME7eYZt0MkiOBWntkJDapDfL3Vo-ON2e7-eJXAQJBHmHfbFciHGdamaWnY9ZVt-KXUwhJwYCHziRzA4Be5uTcegSRUCGYmTuyXENWuaBQjGKB8_RyJdcGU4YBlQylZbCGiJdskxOGQRduGyNy8oSF4qm366MNluEM0dPmkxAoBoGGRNrBo8llzE6_8HL6T7zoVqc0EZ6vOmqenp_-3z9WJPnI0WPihyl4_7Qtpum3TZN-9J1u83zf_9-ADkFZU8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>construto e proteína aglutinantes ao antígeno, dímero, composição farmacêutica, sequência de polinucleotídeo, célula hospedeira e, método para produção do construto</title><source>esp@cenet</source><creator>ALAN PETER LEWIS ; ZOE HUGHES-THOMAS ; IAN RICHARD CATCHPOLE ; MICHAEL STEWARD ; CLAIRE ASHMAN</creator><creatorcontrib>ALAN PETER LEWIS ; ZOE HUGHES-THOMAS ; IAN RICHARD CATCHPOLE ; MICHAEL STEWARD ; CLAIRE ASHMAN</creatorcontrib><description>The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularization, and polynucleotide sequences encoding said antigen binding constructs.</description><language>por</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170221&DB=EPODOC&CC=BR&NR=112014001855A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170221&DB=EPODOC&CC=BR&NR=112014001855A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ALAN PETER LEWIS</creatorcontrib><creatorcontrib>ZOE HUGHES-THOMAS</creatorcontrib><creatorcontrib>IAN RICHARD CATCHPOLE</creatorcontrib><creatorcontrib>MICHAEL STEWARD</creatorcontrib><creatorcontrib>CLAIRE ASHMAN</creatorcontrib><title>construto e proteína aglutinantes ao antígeno, dímero, composição farmacêutica, sequência de polinucleotídeo, célula hospedeira e, método para produção do construto</title><description>The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularization, and polynucleotide sequences encoding said antigen binding constructs.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjr1qw0AQhNW4ME7eYZt0MkiOBWntkJDapDfL3Vo-ON2e7-eJXAQJBHmHfbFciHGdamaWnY9ZVt-KXUwhJwYCHziRzA4Be5uTcegSRUCGYmTuyXENWuaBQjGKB8_RyJdcGU4YBlQylZbCGiJdskxOGQRduGyNy8oSF4qm366MNluEM0dPmkxAoBoGGRNrBo8llzE6_8HL6T7zoVqc0EZ6vOmqenp_-3z9WJPnI0WPihyl4_7Qtpum3TZN-9J1u83zf_9-ADkFZU8</recordid><startdate>20170221</startdate><enddate>20170221</enddate><creator>ALAN PETER LEWIS</creator><creator>ZOE HUGHES-THOMAS</creator><creator>IAN RICHARD CATCHPOLE</creator><creator>MICHAEL STEWARD</creator><creator>CLAIRE ASHMAN</creator><scope>EVB</scope></search><sort><creationdate>20170221</creationdate><title>construto e proteína aglutinantes ao antígeno, dímero, composição farmacêutica, sequência de polinucleotídeo, célula hospedeira e, método para produção do construto</title><author>ALAN PETER LEWIS ; ZOE HUGHES-THOMAS ; IAN RICHARD CATCHPOLE ; MICHAEL STEWARD ; CLAIRE ASHMAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BR112014001855A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ALAN PETER LEWIS</creatorcontrib><creatorcontrib>ZOE HUGHES-THOMAS</creatorcontrib><creatorcontrib>IAN RICHARD CATCHPOLE</creatorcontrib><creatorcontrib>MICHAEL STEWARD</creatorcontrib><creatorcontrib>CLAIRE ASHMAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ALAN PETER LEWIS</au><au>ZOE HUGHES-THOMAS</au><au>IAN RICHARD CATCHPOLE</au><au>MICHAEL STEWARD</au><au>CLAIRE ASHMAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>construto e proteína aglutinantes ao antígeno, dímero, composição farmacêutica, sequência de polinucleotídeo, célula hospedeira e, método para produção do construto</title><date>2017-02-21</date><risdate>2017</risdate><abstract>The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularization, and polynucleotide sequences encoding said antigen binding constructs.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	por
recordid	cdi_epo_espacenet_BR112014001855A2
source	esp@cenet
subjects	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	construto e proteína aglutinantes ao antígeno, dímero, composição farmacêutica, sequência de polinucleotídeo, célula hospedeira e, método para produção do construto
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T13%3A31%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ALAN%20PETER%20LEWIS&rft.date=2017-02-21&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EBR112014001855A2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true