anticorpos anti-psgl-1 e seu uso

abstract provided herein, in one aspect, are antibodies that immunospecifically bind to psgl-1, polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. also provided herein are kits and pharmaceutical compositions...

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Hauptverfasser: BARBARA ENENKEL, HEIDRUN SCHOTT, PATRICK GARIDEL, STEFAN BASSARAB, SANJAYA SINGH, TOBIAS LITZENBURGER
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creator BARBARA ENENKEL
HEIDRUN SCHOTT
PATRICK GARIDEL
STEFAN BASSARAB
SANJAYA SINGH
TOBIAS LITZENBURGER
description abstract provided herein, in one aspect, are antibodies that immunospecifically bind to psgl-1, polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to psgl-1, as well as methods of treating a disorder or disease caused by or associated with increased proliferation and/or numbers of activated t cells using the antibodies described herein. _____________________________________________________________________ tradução resumo resumo patente de invenção: "anticorpos anti-psgl-1 e seu uso". são aqui fornecidos, em um aspecto, anticorpos que imunoespecificamente se ligam ao psgl-1, polinucleotídeos compreendendo as seqüências de nucleotídeo que codificam tais anticorpos, e vetores de expressão e células hospedeiras para a produção de tais anticorpos. também são aqui fornecidos kits e composições farmacêuticas compreendendo anticorpos que especificamente se ligam ao psgl-1, assim como métodos de tratamento de um distúrbio ou doença provocado ou associado com o aumento da proliferação e/ou os números de células t ativadas usando os anticorpos aqui descritos. Provided herein, in one aspect, are antibodies that immunospecifically bind to PSGL- 1, polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to PSGL- 1, as well as methods of treating a disorder or disease caused by or associated with increased proliferation and/or numbers of activated T cells using the antibodies described herein.
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PEPTIDES
title anticorpos anti-psgl-1 e seu uso
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