métodos para aumentar atividade de diidróxi ácido desidratase para aperfeiçoar produção de combustíveis, produtos químicos e aminoácidos
The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In va...
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| creator | CATHERINE ASLESON DUNDON ARISTOS ARISTIDOU STEPHANIE PORTER-SCHEINMAN DOUG LIES PETER MEINHOLD RENNY FELDMAN CHRISTOPHER SMITH ANDREW HAWKINS MATTHEW PETERS THOMAS BUELTER JUN URANO LYNNE ALBERT |
| description | The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms. |
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In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.</description><language>por</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190924&DB=EPODOC&CC=BR&NR=112012012492A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190924&DB=EPODOC&CC=BR&NR=112012012492A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CATHERINE ASLESON DUNDON</creatorcontrib><creatorcontrib>ARISTOS ARISTIDOU</creatorcontrib><creatorcontrib>STEPHANIE PORTER-SCHEINMAN</creatorcontrib><creatorcontrib>DOUG LIES</creatorcontrib><creatorcontrib>PETER MEINHOLD</creatorcontrib><creatorcontrib>RENNY FELDMAN</creatorcontrib><creatorcontrib>CHRISTOPHER SMITH</creatorcontrib><creatorcontrib>ANDREW HAWKINS</creatorcontrib><creatorcontrib>MATTHEW PETERS</creatorcontrib><creatorcontrib>THOMAS BUELTER</creatorcontrib><creatorcontrib>JUN URANO</creatorcontrib><creatorcontrib>LYNNE ALBERT</creatorcontrib><title>métodos para aumentar atividade de diidróxi ácido desidratase para aperfeiçoar produção de combustíveis, produtos químicos e aminoácidos</title><description>The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNTTsKwkAUTGMh6h22sVMw0cZSRbEW-_DcfYEHbnbdT_AaHkEsgkUqj7AXc2NyAGFghnkz84bJQ4a3U0JZpsEAAy-xdGAYOKpIgEDWgkiY8LkTC09OQkXPRgccWOx7Gk2BFGoVu9oo4UMdXm2QcSUv3rrQVEh21h1d_HfzoZHEo0IGkkrVbdtxMijganHS8yiZHvbn3XGOWuVoNXAs0eXbU5pmix9W62yTLf_NfQGdDFfw</recordid><startdate>20190924</startdate><enddate>20190924</enddate><creator>CATHERINE ASLESON DUNDON</creator><creator>ARISTOS ARISTIDOU</creator><creator>STEPHANIE PORTER-SCHEINMAN</creator><creator>DOUG LIES</creator><creator>PETER MEINHOLD</creator><creator>RENNY FELDMAN</creator><creator>CHRISTOPHER SMITH</creator><creator>ANDREW HAWKINS</creator><creator>MATTHEW PETERS</creator><creator>THOMAS BUELTER</creator><creator>JUN URANO</creator><creator>LYNNE ALBERT</creator><scope>EVB</scope></search><sort><creationdate>20190924</creationdate><title>métodos para aumentar atividade de diidróxi ácido desidratase para aperfeiçoar produção de combustíveis, produtos químicos e aminoácidos</title><author>CATHERINE ASLESON DUNDON ; ARISTOS ARISTIDOU ; STEPHANIE PORTER-SCHEINMAN ; DOUG LIES ; PETER MEINHOLD ; RENNY FELDMAN ; CHRISTOPHER SMITH ; ANDREW HAWKINS ; MATTHEW PETERS ; THOMAS BUELTER ; JUN URANO ; LYNNE ALBERT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BR112012012492A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2019</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CATHERINE ASLESON DUNDON</creatorcontrib><creatorcontrib>ARISTOS ARISTIDOU</creatorcontrib><creatorcontrib>STEPHANIE PORTER-SCHEINMAN</creatorcontrib><creatorcontrib>DOUG LIES</creatorcontrib><creatorcontrib>PETER MEINHOLD</creatorcontrib><creatorcontrib>RENNY FELDMAN</creatorcontrib><creatorcontrib>CHRISTOPHER SMITH</creatorcontrib><creatorcontrib>ANDREW HAWKINS</creatorcontrib><creatorcontrib>MATTHEW PETERS</creatorcontrib><creatorcontrib>THOMAS BUELTER</creatorcontrib><creatorcontrib>JUN URANO</creatorcontrib><creatorcontrib>LYNNE ALBERT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CATHERINE ASLESON DUNDON</au><au>ARISTOS ARISTIDOU</au><au>STEPHANIE PORTER-SCHEINMAN</au><au>DOUG LIES</au><au>PETER MEINHOLD</au><au>RENNY FELDMAN</au><au>CHRISTOPHER SMITH</au><au>ANDREW HAWKINS</au><au>MATTHEW PETERS</au><au>THOMAS BUELTER</au><au>JUN URANO</au><au>LYNNE ALBERT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>métodos para aumentar atividade de diidróxi ácido desidratase para aperfeiçoar produção de combustíveis, produtos químicos e aminoácidos</title><date>2019-09-24</date><risdate>2019</risdate><abstract>The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | métodos para aumentar atividade de diidróxi ácido desidratase para aperfeiçoar produção de combustíveis, produtos químicos e aminoácidos |
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