DISPOSITIVO MICROFLUÍDICO

DISPOSITIVO MICROFLUÍDICO. A presente invenção materializa-se em um dispositivo microfluídico inovador capaz de melhorar a seleção de ligantes de maior especificidade de bibliotecas de biomoléculas contra culturas de células ou tecidos humanos, especialmente durante a seleção de aptâmeros por SELEX. This invention consists of a method for the development of personalized target anticancer therapies based on aptamers and through the systemic modeling of an individual in microfluidic devices. This invention is embodied in microfluidic devices, connections, systems, and methods for the development specific aptamers for the relevant complex biological environment targets. In a first mode, the invention provides methods for the development of target therapies which involves the maintenance of target cancerous cells in co-culture with non-target and non-cancerous cells by using microfluidic devices modularly arranged in closed systems for the development of aptamers. In a second mode, the invention provides a method for the development of target therapies, which includes the maintenance of target cells in co-culture with non-target cells by using microfluidic devices modularly arranged in closed systems. In this case, the invention provides the development of aptamers for the relevant target in homeostatic balance with the components of the fluid conditioned by the co-culture with non-target cells.