Tetralonas 5-substituìdas como inibidores de farnesil transferase de ras
"TETRALONAS 5-SUBSTITUìDAS COMO INIBIDORES DE FARNESIL TRANSFERASE DE RAS". A presente invenção provê tetralonas 5-substituídas das Fórmulas (I), (II), (III) e (IV) e seus sais, ésteres, amidas e pró-drogas farmaceuticamente aceitáveis, que são úteis para o tratamento e prevenção de prolif...
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| creator | DANIELE MARIE LEONARD DOUGLAS S. JOHNSON JAMES STANLEY KAL TENBRONN RICHARD H. HUTCHINGS GORDON WILLIAM REWCASTLE HO HUAT LEE JOSEPH THOMAS REPINE WILLIAM ALEXANDER DENNY JARED BRUCE JOHN MILBANK ANDREW DAVID WHITE |
| description | "TETRALONAS 5-SUBSTITUìDAS COMO INIBIDORES DE FARNESIL TRANSFERASE DE RAS". A presente invenção provê tetralonas 5-substituídas das Fórmulas (I), (II), (III) e (IV) e seus sais, ésteres, amidas e pró-drogas farmaceuticamente aceitáveis, que são úteis para o tratamento e prevenção de proliferação de tecidos incontrolada ou anormal, tal como câncer, aterosclerose, restenose e psoríase. Especificamente, a presente invenção refere-se a compostos que inibem a enzima farnesil transferase.
The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme |
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The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme</description><edition>7</edition><language>por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030121&DB=EPODOC&CC=BR&NR=0110142A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030121&DB=EPODOC&CC=BR&NR=0110142A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DANIELE MARIE LEONARD</creatorcontrib><creatorcontrib>DOUGLAS S. JOHNSON</creatorcontrib><creatorcontrib>JAMES STANLEY KAL TENBRONN</creatorcontrib><creatorcontrib>RICHARD H. HUTCHINGS</creatorcontrib><creatorcontrib>GORDON WILLIAM REWCASTLE</creatorcontrib><creatorcontrib>HO HUAT LEE</creatorcontrib><creatorcontrib>JOSEPH THOMAS REPINE</creatorcontrib><creatorcontrib>WILLIAM ALEXANDER DENNY</creatorcontrib><creatorcontrib>JARED BRUCE JOHN MILBANK</creatorcontrib><creatorcontrib>ANDREW DAVID WHITE</creatorcontrib><title>Tetralonas 5-substituìdas como inibidores de farnesil transferase de ras</title><description>"TETRALONAS 5-SUBSTITUìDAS COMO INIBIDORES DE FARNESIL TRANSFERASE DE RAS". A presente invenção provê tetralonas 5-substituídas das Fórmulas (I), (II), (III) e (IV) e seus sais, ésteres, amidas e pró-drogas farmaceuticamente aceitáveis, que são úteis para o tratamento e prevenção de proliferação de tecidos incontrolada ou anormal, tal como câncer, aterosclerose, restenose e psoríase. Especificamente, a presente invenção refere-se a compostos que inibem a enzima farnesil transferase.
The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAMSS0pSszJz0ssVjDVLS5NKi7JLCk9vCYFyE_Oz81XyMzLTMpMyS9KLVZISVVISyzKSy3OzFEAasorTkstSixOBYkDaR4G1rTEnOJUXijNzSDv5hri7KGbWpAfn1pckJicmpdaEu8UZGBoaGBoYuRoTFgFAIWzNI0</recordid><startdate>20030121</startdate><enddate>20030121</enddate><creator>DANIELE MARIE LEONARD</creator><creator>DOUGLAS S. JOHNSON</creator><creator>JAMES STANLEY KAL TENBRONN</creator><creator>RICHARD H. HUTCHINGS</creator><creator>GORDON WILLIAM REWCASTLE</creator><creator>HO HUAT LEE</creator><creator>JOSEPH THOMAS REPINE</creator><creator>WILLIAM ALEXANDER DENNY</creator><creator>JARED BRUCE JOHN MILBANK</creator><creator>ANDREW DAVID WHITE</creator><scope>EVB</scope></search><sort><creationdate>20030121</creationdate><title>Tetralonas 5-substituìdas como inibidores de farnesil transferase de ras</title><author>DANIELE MARIE LEONARD ; DOUGLAS S. JOHNSON ; JAMES STANLEY KAL TENBRONN ; RICHARD H. HUTCHINGS ; GORDON WILLIAM REWCASTLE ; HO HUAT LEE ; JOSEPH THOMAS REPINE ; WILLIAM ALEXANDER DENNY ; JARED BRUCE JOHN MILBANK ; ANDREW DAVID WHITE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BR0110142A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2003</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DANIELE MARIE LEONARD</creatorcontrib><creatorcontrib>DOUGLAS S. JOHNSON</creatorcontrib><creatorcontrib>JAMES STANLEY KAL TENBRONN</creatorcontrib><creatorcontrib>RICHARD H. HUTCHINGS</creatorcontrib><creatorcontrib>GORDON WILLIAM REWCASTLE</creatorcontrib><creatorcontrib>HO HUAT LEE</creatorcontrib><creatorcontrib>JOSEPH THOMAS REPINE</creatorcontrib><creatorcontrib>WILLIAM ALEXANDER DENNY</creatorcontrib><creatorcontrib>JARED BRUCE JOHN MILBANK</creatorcontrib><creatorcontrib>ANDREW DAVID WHITE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DANIELE MARIE LEONARD</au><au>DOUGLAS S. JOHNSON</au><au>JAMES STANLEY KAL TENBRONN</au><au>RICHARD H. HUTCHINGS</au><au>GORDON WILLIAM REWCASTLE</au><au>HO HUAT LEE</au><au>JOSEPH THOMAS REPINE</au><au>WILLIAM ALEXANDER DENNY</au><au>JARED BRUCE JOHN MILBANK</au><au>ANDREW DAVID WHITE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Tetralonas 5-substituìdas como inibidores de farnesil transferase de ras</title><date>2003-01-21</date><risdate>2003</risdate><abstract>"TETRALONAS 5-SUBSTITUìDAS COMO INIBIDORES DE FARNESIL TRANSFERASE DE RAS". A presente invenção provê tetralonas 5-substituídas das Fórmulas (I), (II), (III) e (IV) e seus sais, ésteres, amidas e pró-drogas farmaceuticamente aceitáveis, que são úteis para o tratamento e prevenção de proliferação de tecidos incontrolada ou anormal, tal como câncer, aterosclerose, restenose e psoríase. Especificamente, a presente invenção refere-se a compostos que inibem a enzima farnesil transferase.
The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Tetralonas 5-substituìdas como inibidores de farnesil transferase de ras |
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