Aril- e heteroarilsulfonatos
"ARIL- E HETEROARILSULFONATOS". A invenção refere-se a novos aril- e heteroaril-sulfonatos da fórmula (Ia) A-D-O-SO~ 2~-R^ 1^ (Ia) e ao processo para sua preparação, bem como a novos aril- e heteroarilsulfonatos da fórmula (I) A-D-O-SO~ 2~-R^ 1^ (I) para tratamento e/ou profilaxia de doenç...
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| creator | SWEN ALLERHEILIGEN HEINRICH MEIER JEAN-MARIE-VIKTOR DE VRY DIRK DENZER FRANK MAULER VOLKER HINZ MARKUS HEIL PAUL NAAB ARND VOERSTE KLEMENS LUSTIG |
| description | "ARIL- E HETEROARILSULFONATOS". A invenção refere-se a novos aril- e heteroaril-sulfonatos da fórmula (Ia) A-D-O-SO~ 2~-R^ 1^ (Ia) e ao processo para sua preparação, bem como a novos aril- e heteroarilsulfonatos da fórmula (I) A-D-O-SO~ 2~-R^ 1^ (I) para tratamento e/ou profilaxia de doenças, particularmente para tratamento de estados doloridos e doenças neurodegenerativas. Fórmula (Ia) na qual A representa (C~ 6~-C~ 10~)-arila ou heteroarila com 5 até 10 membros, D representa (C~ 6~-C~ 10~)-arileno ou heteroarileno com 5 até 10 membros, R^ 1^ representa (C~ 4~-C~ 8~)-alquila, representa (C~ 2~-C~ 8~)-alquila, sendo que a cadeia de carbono é interrompida com um ou dois heteroátomos ou grupos escolhidos dos grupos -O-, -S-, -SO- e -SO~ 2~-, representa (C~ 2~-C~ 8~)-alquenila, ou representa (C~ 2~-C~ 8~)-alquinila; A - D - O - SO~ 2~ - R^ 1^ (I) na qual R^ 1^ representa (C~ 3~-C~ 8~)-alquila, representa (C~ 2~-C~ 8~)-alquila, sendo que a cadeia de carbono é interrompida com um ou dois heteroátomos ou grupos escolhidos dos grupos -O-, -S-, -SO- e SO~ 2~-, representa (C~ 2~-C~ 8~)-alquenila, ou representa (C~ 2~-C~ 8~)-alquinila.
The invention relates to novel aryl and heteroaryl sulfonates of formula (Ia) and to methods for producing them and to novel aryl and heteroaryl sulfonates of formula (I) for treating and/or preventing diseases, especially for treating pain and neurodegenerative diseases, A representing (C6-C10)-aryl or 5-10-membered heteroaryl, D representing (C6-C10)-arylene or 5-10-membered heteroarylene, R1 representing (C4-C8)-alkyl, (C2-C8)-alkyl, the carbon chain being interrupted by one or two heteroatoms or groups chosen from the following group: -O-, -S-, -SO- and -SO2-, (C2-C8)-alkenyl or (C2-C8)-alkinyl, in formula (Ia); and R1 representing (C3-C8)-alkyl, (C2-C8)-alkyl, the carbon chain being interrupted by one or two heteroatoms or groups chosen from the following group: -O-, -S-,-SO- and -SO2-, (C2-C8)-alkenyl or (C2-C8)-alkinyl. |
| format | Patent |
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The invention relates to novel aryl and heteroaryl sulfonates of formula (Ia) and to methods for producing them and to novel aryl and heteroaryl sulfonates of formula (I) for treating and/or preventing diseases, especially for treating pain and neurodegenerative diseases, A representing (C6-C10)-aryl or 5-10-membered heteroaryl, D representing (C6-C10)-arylene or 5-10-membered heteroarylene, R1 representing (C4-C8)-alkyl, (C2-C8)-alkyl, the carbon chain being interrupted by one or two heteroatoms or groups chosen from the following group: -O-, -S-, -SO- and -SO2-, (C2-C8)-alkenyl or (C2-C8)-alkinyl, in formula (Ia); and R1 representing (C3-C8)-alkyl, (C2-C8)-alkyl, the carbon chain being interrupted by one or two heteroatoms or groups chosen from the following group: -O-, -S-,-SO- and -SO2-, (C2-C8)-alkenyl or (C2-C8)-alkinyl.</description><edition>7</edition><language>por</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030211&DB=EPODOC&CC=BR&NR=0109698A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030211&DB=EPODOC&CC=BR&NR=0109698A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SWEN ALLERHEILIGEN</creatorcontrib><creatorcontrib>HEINRICH MEIER</creatorcontrib><creatorcontrib>JEAN-MARIE-VIKTOR DE VRY</creatorcontrib><creatorcontrib>DIRK DENZER</creatorcontrib><creatorcontrib>FRANK MAULER</creatorcontrib><creatorcontrib>VOLKER HINZ</creatorcontrib><creatorcontrib>MARKUS HEIL</creatorcontrib><creatorcontrib>PAUL NAAB</creatorcontrib><creatorcontrib>ARND VOERSTE</creatorcontrib><creatorcontrib>KLEMENS LUSTIG</creatorcontrib><title>Aril- e heteroarilsulfonatos</title><description>"ARIL- E HETEROARILSULFONATOS". A invenção refere-se a novos aril- e heteroaril-sulfonatos da fórmula (Ia) A-D-O-SO~ 2~-R^ 1^ (Ia) e ao processo para sua preparação, bem como a novos aril- e heteroarilsulfonatos da fórmula (I) A-D-O-SO~ 2~-R^ 1^ (I) para tratamento e/ou profilaxia de doenças, particularmente para tratamento de estados doloridos e doenças neurodegenerativas. Fórmula (Ia) na qual A representa (C~ 6~-C~ 10~)-arila ou heteroarila com 5 até 10 membros, D representa (C~ 6~-C~ 10~)-arileno ou heteroarileno com 5 até 10 membros, R^ 1^ representa (C~ 4~-C~ 8~)-alquila, representa (C~ 2~-C~ 8~)-alquila, sendo que a cadeia de carbono é interrompida com um ou dois heteroátomos ou grupos escolhidos dos grupos -O-, -S-, -SO- e -SO~ 2~-, representa (C~ 2~-C~ 8~)-alquenila, ou representa (C~ 2~-C~ 8~)-alquinila; A - D - O - SO~ 2~ - R^ 1^ (I) na qual R^ 1^ representa (C~ 3~-C~ 8~)-alquila, representa (C~ 2~-C~ 8~)-alquila, sendo que a cadeia de carbono é interrompida com um ou dois heteroátomos ou grupos escolhidos dos grupos -O-, -S-, -SO- e SO~ 2~-, representa (C~ 2~-C~ 8~)-alquenila, ou representa (C~ 2~-C~ 8~)-alquinila.
The invention relates to novel aryl and heteroaryl sulfonates of formula (Ia) and to methods for producing them and to novel aryl and heteroaryl sulfonates of formula (I) for treating and/or preventing diseases, especially for treating pain and neurodegenerative diseases, A representing (C6-C10)-aryl or 5-10-membered heteroaryl, D representing (C6-C10)-arylene or 5-10-membered heteroarylene, R1 representing (C4-C8)-alkyl, (C2-C8)-alkyl, the carbon chain being interrupted by one or two heteroatoms or groups chosen from the following group: -O-, -S-, -SO- and -SO2-, (C2-C8)-alkenyl or (C2-C8)-alkinyl, in formula (Ia); and R1 representing (C3-C8)-alkyl, (C2-C8)-alkyl, the carbon chain being interrupted by one or two heteroatoms or groups chosen from the following group: -O-, -S-,-SO- and -SO2-, (C2-C8)-alkenyl or (C2-C8)-alkinyl.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2003</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJBxLMrM0VVIVchILUktyk8E8opLc9Ly8xJL8ot5GFjTEnOKU3mhNDeDvJtriLOHbmpBfnxqcUFicmpeakm8U5CBoYGlmaWFozFhFQAbGyMe</recordid><startdate>20030211</startdate><enddate>20030211</enddate><creator>SWEN ALLERHEILIGEN</creator><creator>HEINRICH MEIER</creator><creator>JEAN-MARIE-VIKTOR DE VRY</creator><creator>DIRK DENZER</creator><creator>FRANK MAULER</creator><creator>VOLKER HINZ</creator><creator>MARKUS HEIL</creator><creator>PAUL NAAB</creator><creator>ARND VOERSTE</creator><creator>KLEMENS LUSTIG</creator><scope>EVB</scope></search><sort><creationdate>20030211</creationdate><title>Aril- e heteroarilsulfonatos</title><author>SWEN ALLERHEILIGEN ; HEINRICH MEIER ; JEAN-MARIE-VIKTOR DE VRY ; DIRK DENZER ; FRANK MAULER ; VOLKER HINZ ; MARKUS HEIL ; PAUL NAAB ; ARND VOERSTE ; KLEMENS LUSTIG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_BR0109698A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2003</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SWEN ALLERHEILIGEN</creatorcontrib><creatorcontrib>HEINRICH MEIER</creatorcontrib><creatorcontrib>JEAN-MARIE-VIKTOR DE VRY</creatorcontrib><creatorcontrib>DIRK DENZER</creatorcontrib><creatorcontrib>FRANK MAULER</creatorcontrib><creatorcontrib>VOLKER HINZ</creatorcontrib><creatorcontrib>MARKUS HEIL</creatorcontrib><creatorcontrib>PAUL NAAB</creatorcontrib><creatorcontrib>ARND VOERSTE</creatorcontrib><creatorcontrib>KLEMENS LUSTIG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SWEN ALLERHEILIGEN</au><au>HEINRICH MEIER</au><au>JEAN-MARIE-VIKTOR DE VRY</au><au>DIRK DENZER</au><au>FRANK MAULER</au><au>VOLKER HINZ</au><au>MARKUS HEIL</au><au>PAUL NAAB</au><au>ARND VOERSTE</au><au>KLEMENS LUSTIG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Aril- e heteroarilsulfonatos</title><date>2003-02-11</date><risdate>2003</risdate><abstract>"ARIL- E HETEROARILSULFONATOS". A invenção refere-se a novos aril- e heteroaril-sulfonatos da fórmula (Ia) A-D-O-SO~ 2~-R^ 1^ (Ia) e ao processo para sua preparação, bem como a novos aril- e heteroarilsulfonatos da fórmula (I) A-D-O-SO~ 2~-R^ 1^ (I) para tratamento e/ou profilaxia de doenças, particularmente para tratamento de estados doloridos e doenças neurodegenerativas. Fórmula (Ia) na qual A representa (C~ 6~-C~ 10~)-arila ou heteroarila com 5 até 10 membros, D representa (C~ 6~-C~ 10~)-arileno ou heteroarileno com 5 até 10 membros, R^ 1^ representa (C~ 4~-C~ 8~)-alquila, representa (C~ 2~-C~ 8~)-alquila, sendo que a cadeia de carbono é interrompida com um ou dois heteroátomos ou grupos escolhidos dos grupos -O-, -S-, -SO- e -SO~ 2~-, representa (C~ 2~-C~ 8~)-alquenila, ou representa (C~ 2~-C~ 8~)-alquinila; A - D - O - SO~ 2~ - R^ 1^ (I) na qual R^ 1^ representa (C~ 3~-C~ 8~)-alquila, representa (C~ 2~-C~ 8~)-alquila, sendo que a cadeia de carbono é interrompida com um ou dois heteroátomos ou grupos escolhidos dos grupos -O-, -S-, -SO- e SO~ 2~-, representa (C~ 2~-C~ 8~)-alquenila, ou representa (C~ 2~-C~ 8~)-alquinila.
The invention relates to novel aryl and heteroaryl sulfonates of formula (Ia) and to methods for producing them and to novel aryl and heteroaryl sulfonates of formula (I) for treating and/or preventing diseases, especially for treating pain and neurodegenerative diseases, A representing (C6-C10)-aryl or 5-10-membered heteroaryl, D representing (C6-C10)-arylene or 5-10-membered heteroarylene, R1 representing (C4-C8)-alkyl, (C2-C8)-alkyl, the carbon chain being interrupted by one or two heteroatoms or groups chosen from the following group: -O-, -S-, -SO- and -SO2-, (C2-C8)-alkenyl or (C2-C8)-alkinyl, in formula (Ia); and R1 representing (C3-C8)-alkyl, (C2-C8)-alkyl, the carbon chain being interrupted by one or two heteroatoms or groups chosen from the following group: -O-, -S-,-SO- and -SO2-, (C2-C8)-alkenyl or (C2-C8)-alkinyl.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Aril- e heteroarilsulfonatos |
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