OPIOID-ORALE DOSISFORMEN MIT VERLANGERTER FREISETZUNG MIT REDUZIERTEM ALKOHOLINDUZIERTEM "DOSIS DUMPING"

OPIOID-ORALE DOSISFORMEN MIT VERLANGERTER FREISETZUNG MIT REDUZIERTEM ALKOHOLINDUZIERTEM "DOSIS DUMPING"

Beschrieben werden Verfahren der Verabreichung von Opioiden mit verlängerter Freisetzung, einschlieBich, jedoch nicht beschränkt auf, Hydromorphon und Oxycodon, die verbesserte Eigenschaften im Hinblick auf die Co-Verabreichung mit wässrigem Alkohol zeigen. Oral dosage form comprises an opioid and a...

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Hauptverfasser: SATHYAN GAYATRI, DAVAR NIPUN, HASTEDT JAYNE, PORS LINDA HEARNEY, CASADEVALL GEMMA
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creator SATHYAN GAYATRI
DAVAR NIPUN
HASTEDT JAYNE
PORS LINDA HEARNEY
CASADEVALL GEMMA
description Beschrieben werden Verfahren der Verabreichung von Opioiden mit verlängerter Freisetzung, einschlieBich, jedoch nicht beschränkt auf, Hydromorphon und Oxycodon, die verbesserte Eigenschaften im Hinblick auf die Co-Verabreichung mit wässrigem Alkohol zeigen. Oral dosage form comprises an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of the mean unit dose maximum opioid plasma concentration with alcohol coadminstration to the mean unit dose maximum opioid plasma concentration without alcohol co-adminstration is no more than 1.8:1. Independent claims are also included for: (1) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of an individual patient unit dose maximum opioid plasma concentration with alcohol coadminstration to the individual unit dose maximum opioid plasma concentration without alcohol coadminstration is no more than 5:1; (2) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that no more than 80% of the dose is released in 2 hours in an in-vitro test performed in the presence of at least 20 vol.% alcohol. ACTIVITY : Analgesic. MECHANISM OF ACTION : None given.
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title OPIOID-ORALE DOSISFORMEN MIT VERLANGERTER FREISETZUNG MIT REDUZIERTEM ALKOHOLINDUZIERTEM "DOSIS DUMPING"
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