SUBSTITUTED IMIDAZOBENZAZEPINES AND IMIDAZOPYRIDOAZEPINES

PCT No. PCT/US91/07156 Sec. 371 Date Apr. 6, 1993 Sec. 102(e) Date Apr. 6, 1993 PCT Filed Oct. 4, 1991 PCT Pub. No. WO92/06981 PCT Pub. Date Apr. 30, 1992.Compounds of the formula 1.0 wherein R1 is H, C1-C7 alkyl, C3-C7 cycloalkyl, CF3, aryl, substituted aryl, heteroaryl, -O-C1-C7 alkyl, or -O-C3-C7 cycloalkyl; R2 and R3 are each independently H, C1-C7 alkyl, C3-C7 cycloalkyl, CF3, NO2, halogen, OR7, NR8R9 or S(O)mR10, wherein m is 0, 1 or 2; R4 is H, C1-C7 alkyl, arylmethyl, or substituted arylmethyl; R5 and R6 are each independently H, C1-C7 alkyl, C3-C7 cycloalkyl, aryl, substituted aryl, heteroaryl, arylmethyl, substituted arylmethyl, or taken together constitute a chain of (CH2)k groups, wherein k is 3, 4, or 5; R7, R8 and R9 are each independently H, C1-C7 alkyl, -C(=O)-(C1-C7 alkyl), -C(=O)-aryl, or -(C=O)heteroaryl; R10 is C1-C7 alkyl, C3-C7 cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylmethyl, or substituted arylmethyl; one and only one of the dotted lines, a, b, c, and d, represents a carbon-carbon bond; n is 0, 1, 2 or 3; Z is O or S, Q is CH, N, or NO, with the proviso that Z is not S when Q is NO, or a pharmaceutically acceptable acid addition salt thereof, are described. These compounds are useful as agents in the treatment of asthma and other allergic diseases and in the treatment of inflammation.