Milling process for the production of finely milled medicinal substances
The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine me...
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creator | ANDREW B. BROWN N. MURTI VEMURI JEAN-RENE AUTHELIN PATRICK HOSEK |
description | The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced. |
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MURTI VEMURI ; JEAN-RENE AUTHELIN ; PATRICK HOSEK</creatorcontrib><description>The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced.</description><edition>7</edition><language>eng</language><subject>CRUSHING, PULVERISING, OR DISINTEGRATING ; CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; MILLING GRAIN ; PERFORMING OPERATIONS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PREPARATORY TREATMENT OF GRAIN FOR MILLING ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; TRANSPORTING</subject><creationdate>2003</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030717&DB=EPODOC&CC=AU&NR=763352B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20030717&DB=EPODOC&CC=AU&NR=763352B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ANDREW B. BROWN</creatorcontrib><creatorcontrib>N. MURTI VEMURI</creatorcontrib><creatorcontrib>JEAN-RENE AUTHELIN</creatorcontrib><creatorcontrib>PATRICK HOSEK</creatorcontrib><title>Milling process for the production of finely milled medicinal substances</title><description>The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. 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MURTI VEMURI</creatorcontrib><creatorcontrib>JEAN-RENE AUTHELIN</creatorcontrib><creatorcontrib>PATRICK HOSEK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ANDREW B. BROWN</au><au>N. MURTI VEMURI</au><au>JEAN-RENE AUTHELIN</au><au>PATRICK HOSEK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Milling process for the production of finely milled medicinal substances</title><date>2003-07-17</date><risdate>2003</risdate><abstract>The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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subjects | CRUSHING, PULVERISING, OR DISINTEGRATING CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE MILLING GRAIN PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PREPARATORY TREATMENT OF GRAIN FOR MILLING SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING |
title | Milling process for the production of finely milled medicinal substances |
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