Milling process for the production of finely milled medicinal substances

The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine me...

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Hauptverfasser: ANDREW B. BROWN, N. MURTI VEMURI, JEAN-RENE AUTHELIN, PATRICK HOSEK
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creator ANDREW B. BROWN
N. MURTI VEMURI
JEAN-RENE AUTHELIN
PATRICK HOSEK
description The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced.
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subjects CRUSHING, PULVERISING, OR DISINTEGRATING
CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
MILLING GRAIN
PERFORMING OPERATIONS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PREPARATORY TREATMENT OF GRAIN FOR MILLING
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TRANSPORTING
title Milling process for the production of finely milled medicinal substances
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