Synthesis of 11-aryl-5,6-dihydro-11H-dibenz{b,e}azepines

Synthesis of 11-aryl-5,6-dihydro-11H-dibenz{b,e}azepines

Disclosed is a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by the following structural formula:and a starting material represented by the following structural formula:Phenyl Ring A, Phenyl Ring B and Phenyl Ring C are independently unsub...

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Hauptverfasser: REEM M. HAIDER, RICHARD J. LOMBARDY, MINGHUA SUN, ADEL M. MOUSSA
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Sprache:eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator REEM M. HAIDER
RICHARD J. LOMBARDY
MINGHUA SUN
ADEL M. MOUSSA
description Disclosed is a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by the following structural formula:and a starting material represented by the following structural formula:Phenyl Ring A, Phenyl Ring B and Phenyl Ring C are independently unsubstituted or substituted with one, two or three substituents. Each substituent on Phenyl Ring A, Phenyl Ring B and Phenyl Ring C is independently chosen.R is -H, a aliphatic group, a substituted aliphatic group, an aryl group, a substituted aryl group, -C(O)-R', -C(O)-H, -C(O)-NHR', -S(O)2R', -C(O)-C(O)-R', -C(O)-C(O)-H, -C(S)-R', -C(S)-H, -C(O)-OR', -C(S)-OR', -C(O)-SR', -C(S)-SR', -C(O)-NR'2 or -C(O)-C(S)-R'. R' is an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group.R1 is a leaving group.The present invention also includes novel compounds which are intermediates in the preparation of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Synthesis of 11-aryl-5,6-dihydro-11H-dibenz{b,e}azepines
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