Kappa agonist compounds and pharmaceutical formulations thereof

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.The compounds of formula having the structure:whereinR1, R2, and X Y, Z, Ar and n are as described in the specification.

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Hauptverfasser: DEQI GUO, FORREST GAUL, ALAN L. MAYCOCK, MICHAEL ANTHONY MARELLA, WEI YUAN ZHANG, VIRENDRA KUMAR, ANIH CHANG
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creator DEQI GUO
FORREST GAUL
ALAN L. MAYCOCK
MICHAEL ANTHONY MARELLA
WEI YUAN ZHANG
VIRENDRA KUMAR
ANIH CHANG
description Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.The compounds of formula having the structure:whereinR1, R2, and X Y, Z, Ar and n are as described in the specification.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Kappa agonist compounds and pharmaceutical formulations thereof
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