Kappa agonist compounds and pharmaceutical formulations thereof

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.The compounds of formula having the structure:whereinR1, R2, and X Y, Z, Ar and n are as described in the specification.

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Bibliographische Detailangaben
Hauptverfasser:	DEQI GUO, FORREST GAUL, ALAN L. MAYCOCK, MICHAEL ANTHONY MARELLA, WEI YUAN ZHANG, VIRENDRA KUMAR, ANIH CHANG
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.The compounds of formula having the structure:whereinR1, R2, and X Y, Z, Ar and n are as described in the specification.