Process for the preparation of (thio-)carbonic/carbamic acid 2-pyrrolidonyl-3-esters, thio esters and amides

A process for the preparation of a compound of general formula II: II wherein R1 is hydrogen, or C1-C10 hydrocarbyl or heterocyclyl having 3 to 8 ring atoms, either of which may optionally be substituted; each R2, R3, R4 and R5 is independently hydrogen or C1-C4 alkyl; A is an optionally substituted...

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Hauptverfasser:	JOHN MICHAEL COX, KEVIN JAMES GILLEN, SHAHEEN KHATOON VOHRA, IAN RICHARD MATTHEWS, STEPHEN CHRISTOPHER SMITH, RUSSELL MARTIN ELLIS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	JOHN MICHAEL COX KEVIN JAMES GILLEN SHAHEEN KHATOON VOHRA IAN RICHARD MATTHEWS STEPHEN CHRISTOPHER SMITH RUSSELL MARTIN ELLIS
description	A process for the preparation of a compound of general formula II: II wherein R1 is hydrogen, or C1-C10 hydrocarbyl or heterocyclyl having 3 to 8 ring atoms, either of which may optionally be substituted; each R2, R3, R4 and R5 is independently hydrogen or C1-C4 alkyl; A is an optionally substituted aromatic or heteroaromatic ring system; and R21 is hydrogen, halogen, OH or OCONHR1, wherein R1 is as defined above; the process comprising cyclizing a compound of general formula III: are as defined in general formula II and R25 is a leaving group such as a halogen atom; under basic conditions.
format	Patent
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	Process for the preparation of (thio-)carbonic/carbamic acid 2-pyrrolidonyl-3-esters, thio esters and amides
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