HEXAHYDROPYRROLO(2,3-B)INDOLE CARBAMATES, -UREAS, -AMIDES AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND AND THEIR USE AS MEDICAMENTS
The present invention relates to compounds of the formula I, where X is O, S, NH, N-loweralkyl, or N-arylloweralkyl; Y is hydrogen, fluorine, chlorine, bromine, nitro, loweralkyl, loweralkoxy, or triloweralkylsilyl; R1 is loweralkyl, halogen-substituted loweralkyl, aryl, arylloweralkyl, cycloalkyl,...
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| creator | JOHN IRVING WHITE GERALD JOSEPH O'MALLEY RICHARD CHARLES ALLEN |
| description | The present invention relates to compounds of the formula I, where X is O, S, NH, N-loweralkyl, or N-arylloweralkyl; Y is hydrogen, fluorine, chlorine, bromine, nitro, loweralkyl, loweralkoxy, or triloweralkylsilyl; R1 is loweralkyl, halogen-substituted loweralkyl, aryl, arylloweralkyl, cycloalkyl, heteroaryl or heteroarylloweralkyl; R2 is hydrogen, loweralkyl or arylloweralkyl; R3 is loweralkyl or arylloweralkyl; R4 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl or loweralkoxycarbonyl; R5 is hydrogen or loweralkyl; and m is 0 or 1, with the proviso that when m is 0, R1 may also be hydrogen, and a process for their preparation. The compounds of the invention are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease. |
| format | Patent |
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The compounds of the invention are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.</description><edition>5</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910808&DB=EPODOC&CC=AU&NR=7011191A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910808&DB=EPODOC&CC=AU&NR=7011191A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JOHN IRVING WHITE</creatorcontrib><creatorcontrib>GERALD JOSEPH O'MALLEY</creatorcontrib><creatorcontrib>RICHARD CHARLES ALLEN</creatorcontrib><title>HEXAHYDROPYRROLO(2,3-B)INDOLE CARBAMATES, -UREAS, -AMIDES AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND AND THEIR USE AS MEDICAMENTS</title><description>The present invention relates to compounds of the formula I, where X is O, S, NH, N-loweralkyl, or N-arylloweralkyl; Y is hydrogen, fluorine, chlorine, bromine, nitro, loweralkyl, loweralkoxy, or triloweralkylsilyl; R1 is loweralkyl, halogen-substituted loweralkyl, aryl, arylloweralkyl, cycloalkyl, heteroaryl or heteroarylloweralkyl; R2 is hydrogen, loweralkyl or arylloweralkyl; R3 is loweralkyl or arylloweralkyl; R4 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl or loweralkoxycarbonyl; R5 is hydrogen or loweralkyl; and m is 0 or 1, with the proviso that when m is 0, R1 may also be hydrogen, and a process for their preparation. 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The compounds of the invention are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HEXAHYDROPYRROLO(2,3-B)INDOLE CARBAMATES, -UREAS, -AMIDES AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND AND THEIR USE AS MEDICAMENTS |
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